Low serum osteoprotegerin levels in premenopausal infertile women with low bone density: an association of relevance?

Fertility and Sterility

Volumn 91, Issue 2, 2009, Pages 542-548

  Norian, John M ^a   Zeitlian, Gohar ^b   Adel, Goli ^b   Freeman, Ruth G ^b   Santoro, Nanette F ^b   Pal, Lubna ^c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMD; infertility; Osteoprotegerin; premenopause; RANKL

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE BONE ISOENZYME; AMINO TERMINAL TELOPEPTIDE; BONE SPECIFIC ALKALINE PHOSPHATASE; ESTRADIOL; FOLLITROPIN; OSTEOCALCIN; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; UNCLASSIFIED DRUG;

ADULT; ANAMNESIS; ARTICLE; BLOOD SAMPLING; BONE DENSITY; BONE METABOLISM; CELL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; FEMALE; FEMALE INFERTILITY; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; OSTEOCLAST; OSTEOLYSIS; OVARIAN RESERVE; PREDICTOR VARIABLE; PREMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUESTIONNAIRE;

ABSORPTIOMETRY, PHOTON; ACID PHOSPHATASE; ADULT; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; BONE DENSITY; COLLAGEN TYPE I; CROSS-SECTIONAL STUDIES; DOWN-REGULATION; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; INFERTILITY, FEMALE; ISOENZYMES; LOGISTIC MODELS; OSTEOPROTEGERIN; PEPTIDES; PREMENOPAUSE; QUESTIONNAIRES; RANK LIGAND;

EID: 59249086905     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.11.089     Document Type: Article

References (32)

1. Facts and statistics about osteoporosis and its impact. © Copyright 1999-2007 International Osteoporosis Foundation. Available at: http://www.iofbonehealth.org/facts-and-statistics.html. Last accessed April 22, 2008.
2. Cummings S.R., Black D.M., Nevitt M.C., Browner W., Cauley J., Ensrud K., et al. Bone density at various sites for prediction of hip fractures. Study of Osteoporotic Fractures Research Group. Lancet 341 (1993) 72-75
3. Brown D.M., Jowsey J., and Bradford D.S. Osteoporosis in ovarian dysgenesis. J Pediatr 84 (1974) 816-820
4. Uygur D., Sengul O., Bayar D., Erdinc S., Batioglu S., and Mollamahmutoglu L. Bone loss in young women with premature ovarian failure. Arch Gynecol Obstet 273 (2005) 17-19
5. Lucas A.R., Melton III L.J., Crowson C.S., and O'Fallon W.M. Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc 74 (1999) 972-977
6. White C.M., Hergenroeder A.C., and Klish W.J. Bone mineral density in 15- to 21-year-old eumenorrheic and amenorrheic subjects. Am J Dis Child 146 (1992) 31-35
7. Melton III L.J., Hesdorffer D.C., Malkasian G.D., Atkinson E.J., Brinton L.A., and O'Fallon W.M. Long-term fracture risk among infertile women: a population-based cohort study. J Womens Health Gend Based Med 10 (2001) 289-297
8. Ahlborg H.G., Johnell O., Nilsson B.E., Jeppsson S., Rannevik G., and Karlsson M.K. Bone loss in relation to menopause: a prospective study during 16 years. Bone 28 (2001) 327-331
9. Sowers M., Crutchfield M., Bandekar R., Randolph J.F., Shapiro B., Schork M.A., et al. Bone mineral density and its change in pre- and perimenopausal white women: the Michigan Bone Health Study. J Bone Miner Res 13 (1998) 1134-1140
10. Garnero P., Sornay-Rendu E., Claustrat B., and Delmas P.D. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res 15 (2000) 1526-1536
11. Khan A.A., and Syed Z. Bone densitometry in premenopausal women. J Clin Densitom 7 (2004) 85-92
12. Khan A., and Syed Z. Bone mineral density assessment in premenopausal women. Future Med 2 (2006) 639-645
13. Lewiecki E.M. Low bone mineral density in premenopausal women. South Med J 97 (2004) 544-550
14. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
15. Rogers A., and Eastell R. Circulating osteoprotegerin and receptor activator for nuclear factor κB ligand: clinical utility in metabolic bone disease assessment. J Clin Endocrinol Metab 90 (2005) 6323-6331
16. Mizuno A., Amizuka N., Irie K., Murakami A., Fujise N., Kanno T., et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Comm 247 (1998) 610-615
17. McClung M.R., Lewiecki E.M., Cohen S.B., Bolognese M.A., Woodson G.C., Moffett A.H., et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354 (2006) 821-831
18. Achilles InSight, Imaging Bone Ultrasonometer (2004), General Electric Medical Systems, Waukesha, WI
19. Martin J.S., Nisker J.A., Tummon I.S., Daniel S.A., Auckland J.L., and Feyles V. Future in vitro fertilization pregnancy potential of women with variably elevated day 3 follicle-stimulating hormone levels. Fertil Steril 65 (1996) 1238-1240
20. Bowen S., Norian J., Santoro N., and Pal L. Simple tools for assessment of ovarian reserve (OR): individual ovarian dimensions are reliable predictors of OR. Fertil Steril 88 (2007) 390-395
21. Kurth T., Walker A.M., Glynn R.J., Chan K.A., Gaziano J.M., Berger K., et al. Results of multivariable logistic regression, propensity matching, propensity adjustment and propensity based weighting under conditions of non union effect. Am J Epidemiol 163 (2006) 262-270
22. Fahrleitner A., Prenner G., Leb G., Tscheliessnigg K.H., Piswanger-Solkner C., Obermayer-Pietsch B., et al. Serum osteoprotegerin is a major determinant of bone density development and prevalent vertebral fracture status following cardiac transplantation. Bone 32 (2003) 96-106
23. Khosla S., Arrighi H.M., Melton III L.J., Atkinson E.J., O'Fallon W.M., Dunstan C., et al. Correlates of osteoprotegerin levels in women and men. Osteoporos Int 13 (2002) 394-399
24. Yano K., Tsuda E., Washida N., Kobayashi F., Goto M., Harada A., et al. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis. J Bone Miner Res 14 (1999) 518-527
25. Arrighi H.M., Khosla S., Melton III L.J., Riggs B.L., Bekker P.J., and Dunstan C.R. The relationship between circulating osteoprotegerin and estrogen in postmenopausal women. J Bone Miner Res 15 (2000) S118
26. Torstveit M.K., and Sundgot-Borgen J. Low bone mineral density is two to three times more prevalent in non-athletic premenopausal women than in elite athletes: a comprehensive controlled study. Br J Sports Med 39 (2005) 282-287
27. Hawker G.A., Jamal S.A., Ridout R., and Chase C. A clinical prediction rule to identify premenopausal women with low bone mass. Osteoporos Int 13 (2002) 400-406
28. Rogers A., Saleh G., Hannon R.A., Greenfield D., and Eastell R. Circulating estradiol and osteoprotegerin as determinants of bone turnover and bone density in postmenopausal women. J Clin Endocrinol Metab 87 (2002) 4470-4475
29. Sowers M., Randolph Jr. J.F., Crutchfield M., Jannausch M.L., Shapiro B., Zhang B., et al. Urinary ovarian and gonadotropin hormone levels in premenopausal women with low bone mass. J Bone Miner Res 13 (1998) 1191-1202
30. Sun L., Peng Y., Sharrow A.C., Iqbal J., Zhang Z., Papachristou D.J., et al. FSH directly regulates bone mass. Cell 125 (2006) 247-260
31. Hawa G., Brinskelle-Schmal N., Glatz K., Maitzen S., and Woloszczuk W. Immunoassay for soluble RANKL (receptor activator of NF-κB ligand) in serum. Clin Lab 49 (2003) 461-463
32. Hans D., Dargent-Molina P., Schott A.M., Sebert J.L., Cormier C., Kotzki P.O., et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348 (1996) 511-514