Disruption of the integrin αLβ2 transmembrane domain interface by β2 Thr-686 mutation activates αLβ2 and promotes micro-clustering of the αL subunits

Journal of Biological Chemistry

Volumn 284, Issue 5, 2009, Pages 3239-3249

  Vararattanavech, Ardcharaporn ^a   Lin, Xin ^a   Torres, Jaume ^a   Tan, Suet Mien ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ADHESION; BINDING ENERGY; BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CELL ADHESION; CELL MEMBRANES; LIGANDS; SIGNALING;

AFFINITY RECEPTORS; BIDIRECTIONAL SIGNALING; BINDING PROPERTIES; BIOLOGICAL PROCESS; CELL ADHESION MOLECULES; CLUSTER FORMATIONS; CYSTEINE-SCANNING; CYTOPLASMIC DOMAINS; DISULFIDE BONDS; ECTODOMAIN; INTEGRIN; INTEGRINS; INTERFACE RESIDUES; LIGAND BINDING AFFINITIES; LIGAND-BINDING SITES; MICROENVIRONMENT; TRANS-MEMBRANE DOMAINS;

BINDING SITES;

ALPHA INTEGRIN; CYSTEINE; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KIM 127; PROTEIN ALPHA L BETA2; THREONINE; UNCLASSIFIED DRUG; DISULFIDE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PLASMID; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CELL LINE; DISULFIDES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; IMMUNOPRECIPITATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE;

EID: 59149102202     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802782200     Document Type: Article

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