The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 1, 2009, Pages 165-173

  Hegde, Laxminarayan G ^a,b   Ping, Xiao Li ^a,c   Jochnowitz, Nina ^a,c   Craig, Douglas A ^a  

^a LUNDBECK RESEARCH USA   (United States)

^b THERAVANCE INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; METHYL 3 [[[3 [4 [3 (ACETYLAMINO)PHENYL] 1 PIPERIDINYL]PROPYL]AMINO]CARBONYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDRO 5 PYRIMIDINECARBOXYLATE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NEUROPEPTIDE; OXYBUTYNIN; SNAP 7941; UNCLASSIFIED DRUG; MCH1R PROTEIN, RAT; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SNAP7941; SOMATOSTATIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLADDER CAPACITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; HYPOTHALAMUS; MALE; MICTURITION REFLEX; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; URINARY FREQUENCY; ANIMAL; BLADDER; BLADDER DISEASE; DIURESIS; DRUG ANTAGONISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KIDNEY PROXIMAL TUBULE; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; REFLEX; SPRAGUE DAWLEY RAT;

ANIMALS; DIURESIS; FEMALE; INJECTIONS, INTRAVENTRICULAR; KIDNEY TUBULES, PROXIMAL; PIPERIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; REFERENCE VALUES; REFLEX; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 59149101216     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.143495     Document Type: Article

References (36)

1. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, and Wein A (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:167-178.
2. Andersson KE (2004) Mechanisms of disease: central nervous system involvement in overactive bladder syndrome. Nat Clin Pract Urol 1:103-108.
3. Andersson KE, Chapple C, and Wein A (2001) The basis for drug treatment of the overactive bladder. World J Urol 19:294-298.
4. Angelico P, Velasco C, Guarneri L, Sironi G, Leonardi A, and Testa R (2005) Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions. BMC Pharmacol 5:14.
5. Athwal BS, Berkley KJ, Hussain I, Brennan A, Craggs M, Sakakibara R, Frackowiak RS, and Fowler CJ (2001) Brain responses to changes in bladder volume and urge to void in healthy men. Brain 124:369 -377.
6. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, et al. (2002) Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med 8:825-830.
7. Burgard EC, Fraser MO, Karicheti V, Ricca DJ, and Thor KB (2005) New pharmacological treatments for urinary incontinence and overactive bladder. Curr Opin Investig Drugs 6:81-89.
8. Chapple C, Khullar V, Gabriel Z, and Dooley JA (2005) The effects of antimuscarinic treatments in overactive bladder: a systematic review and meta-analysis. Eur Urol 48:5-26.
9. Clemow DB, McCarty R, Steers WD, and Tuttle JB (1997) Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats. Neurourol Urodyn 16:293-303.
10. de Groat WC (1997) A neurologic basis for the overactive bladder. Urology 50:36 -52; discussion 53-56.
11. de Groat WC, Kruse MN, Vizzard MA, Cheng CL, Araki I, and Yoshimura N (1997) Modification of urinary bladder function after spinal cord injury. Adv Neurol 72:347-364.
12. Forray C (2003) The MCH receptor family: feeding brain disorders? Curr Opin Pharmacol 3:85-89.
13. Gao X, Hsu CK, Heinz LJ, Morin J, Shi Y, Shukla NK, Smiley DL, Xu J, Zhong B, and Slieker LJ (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem 328:187-195.
14. Hegde SS (2006) Muscarinic receptors in the bladder: from basic research to therapeutics. Br J Pharmacol 147 (Suppl 2):S80 -S87.
15. Hegde SS, Mammen M, and Jasper JR (2004) Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies. Curr Opin Investig Drugs 5:40 -49.
16. Hervieu G (2003) Melanin-concentrating hormone functions in the nervous system: food intake and stress. Expert Opin Ther Targets 7:495-511.
17. Hervieu GJ (2006) Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances. Expert Opin Ther Targets 10:211-229.
18. Hervieu GJ, Cluderay JE, Harrison D, Meakin J, Maycox P, Nasir S, and Leslie RA (2000) The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur J Neurosci 12:1194-1216.
19. Holstege G (2005) Micturition and the soul. J Comp Neurol 493:15-20.
20. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals, 7th ed, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington, DC.
21. Kakizaki H, Yoshiyama M, Koyanagi T, and De Groat WC (2001) Effects of WAY100635, a selective 5-HT1A-receptor antagonist on the micturition-reflex pathway in the rat. Am J Physiol Regul Integr Comp Physiol 280:R1407-R1413.
22. Kennedy AR, Todd JF, Dhillo WS, Seal LJ, Ghatei MA, O'Toole CP, Jones M, Witty D, Winborne K, Riley G, et al. (2003) Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1. J Neuroendocrinol 15:268-272.
23. Klausner AP and Steers WD (2004) Corticotropin releasing factor: a mediator of emotional influences on bladder function. J Urol 172:2570-2573.
24. Klausner AP, Streng T, Na YG, Raju J, Batts TW, Tuttle JB, Andersson KE, and Steers WD (2005) The role of corticotropin releasing factor and its antagonist, astressin, on micturition in the rat. Auton Neurosci 123:26-35.
25. Modiri AR, Alberts P, and Gillberg PG (2002) Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats. Urology 59:963-968.
26. Paxinos G and Watson C (1998) The Rat Brain in Stereotaxic Coordinates, 4th ed, Academic Press, New York.
27. Persson K, Pandita RK, Spitsbergen JM, Steers WD, Tuttle JB, and Andersson KE (1998) Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats. Am J Physiol 275:R1366-R1373.
28. Pissios P, Bradley RL, and Maratos-Flier E (2006) Expanding the scales: the multiple roles of MCH in regulating energy balance and other biological functions. Endocr Rev 27:606 -620.
29. Pissios P and Maratos-Flier E (2003) Melanin-concentrating hormone: from fish skin to skinny mammals. Trends Endocrinol Metab 14:243-248.
30. Scheife R and Takeda M (2005) Central nervous system safety of anticholinergic drugs for the treatment of overactive bladder in the elderly. Clin Ther 27:144-153.
31. Steers WD, Clemow DB, Persson K, Sherer T, Andersson KE, and Tuttl JB (1999) Observations from the spontaneously hypertensive rat: insight into NGF regulation and noradrenergic hyper-innervation in the lower urinary tract. Adv Exp Med Biol 462:283-292; discussion 311-320.
32. Taniguchi N, Miyata M, Yachiku S, Kaneko S, Yamaguchi S, and Numata A (2002) A study of micturition inducing sites in the periaqueductal gray of the mesencephalon. J Urol 168:1626 -1631.
33. Testa R, Guarneri L, Angelico P, Velasco C, Poggesi E, Cilia A, and Leonardi A (2001) Effect of different 5-hydroxytryptamine receptor subtype antagonists on the micturition reflex in rats. BJU Int 87:256 -264.
34. Testa R, Guarneri L, Poggesi E, Angelico P, Velasco C, Ibba M, Cilia A, Motta G, Riva C, and Leonardi A (1999) Effect of several 5-hydroxytryptamine(1A) receptor ligands on the micturition reflex in rats: comparison with WAY 100635. J Pharmacol Exp Ther 290:1258-1269.
35. Valentino Rj, Page ME, Luppi PH, Zhu Y, Van Bockstaele E, and Aston-Jones G (1994) Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons. Neuroscience 62:125-143.
36. Valentino RJ, Pavcovich LA, and Hirata H (1995) Evidence for corticotropin-releasing hormone projections from Barrington's nucleus to the periaqueductal gray and dorsal motor nucleus of the vagus in the rat. J Comp Neurol 363:402-422.