Helicobacter pylori infection in the elderly

International Journal of Gerontology

Volumn 2, Issue 4, 2008, Pages 145-153

  Liou, Jyh Ming ^a   Lin, Jaw Town ^a,b   Lee, Yi Chia ^a,c   Wu, Chun Ying ^d   Wu, Ming Shiang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d Veteran General Hospital   (Taiwan)

Author keywords

Aged; Gastrointestinal diseases; Geriatrics; Helicobacter pylori

Indexed keywords

ACETYLSALICYLIC ACID; AMOXICILLIN; ANTIBIOTIC AGENT; BISMUTH CITRATE; CLARITHROMYCIN; ESOMEPRAZOLE; HISTAMINE H2 RECEPTOR ANTAGONIST; LANSOPRAZOLE; LEVOFLOXACIN; METRONIDAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE; TETRACYCLINE; TINIDAZOLE;

AGED; ANTIBIOTIC RESISTANCE; ATROPHIC GASTRITIS; CANCER RISK; DIAGNOSTIC TEST; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG POTENTIATION; DYSPEPSIA; ERADICATION THERAPY; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; LOW DRUG DOSE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NONHUMAN; PEPTIC ULCER; PREVALENCE; PRIORITY JOURNAL; REVIEW; STOMACH CANCER; UREA BREATH TEST;

EID: 59149098263     PISSN: 18739598     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1873-9598(09)70002-X     Document Type: Review

References (76)

1. Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinoma. Nat Rev Cancer 2002; 2: 28-37.
2. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175-86.
3. Wu MS, Chen CJ, Lin JT. Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 1878-82.
4. Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, et al. Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet 2002; 359: 931-5.
5. Gause-Nilsson I, Gnarpe H, Gnarpe J, Lundborg P, Steen B. Helicobacter pylori serology in elderly people: a 21-year cohort comparison in 70-year-olds and a 20-year longitudinal population study in 70-90-year-olds. Age Ageing 1998; 127: 433-6.
6. Feldman RA. Epidemiologic observations and open questions about disease and infection caused by Helicobacter pylori. In: Achtman M, Suerbaum S, eds. Helicobacter pylori: molecular and cellular biology. Wymondham, United Kingdom: Horizon Scientific Press, 2001; 29-51.
7. Schlemper RJ, van der Werf SD, Biemond I, Lamers CB. Seroepidemiology of gastritis in Japanese and Dutch male employees with and without ulcer disease. Eur J Gastroenterol Hepatol 1996; 8: 33-9.
8. Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330: 1267-71.
9. Wotherspoon AC. Helicobacter pylori infection and gastric lymphoma. Br Med Bull 1998; 54: 79-85.
10. Haruma K, Kamada T, Kawaguchi H, Okamoto S, Yoshihara M, Sumii K, et al. Effect of age and Helicobacter pylori infection on gastric acid secretion. J Gastroenterol Hepatol 2000; 15: 277-83.
11. Pilotto A, Salles N. Helicobacter pylori infection in geriatrics. Helicobacter 2002; 7 (Suppl 1): 56-62.
12. Regev A, Fraser GM, Braun M, Maoz E, Leibovici ML, Niv Y. Seroprevalence of Helicobacter pylori and length of stay in a nursing home. Helicobacter 1999; 4: 89.
13. Pilotto A, Malfertheiner P. Review article: an approach to Helicobacter pylori infection in the elderly. Aliment Pharmacol Ther 2002; 16: 683-91.
14. Linder JD, Wilcox CM. Acid peptic disease in the elderly. Gastroenterol Clin North Am 2001; 30: 363-76.
15. Roll J, Weng A, Newman J. Diagnosis and treatment of Helicobacter pylori infection among California Medicare patients. Arch Intern Med 1997; 157: 994-8.
16. Ofman JJ, Etchason J, Alexander W, Stevens BR, Herrin J, Cangialose C, et al. The quality of care for Medicare patients with peptic ulcer disease. Am J Gastroenterol 2000; 95: 106-13.
17. Dixon MF. Pathology of gastritis and peptic ulceration. In: Mobley HET, Mendz GL, Hazell SL, eds. Helicobacter pylori: physiology and genetics. Washington, DC: ASM Press, 2001; 459-69.
18. Lochhead P, El-Omar EM. Helicobacter pylori infection and gastric cancer. Best Pract Res Clin Gastroenterol 2007; 21: 281-97.
19. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 2001; 6: 294-9.
20. Nakamura M, Haruma K, Kamada T, Mihara M, Yoshihara M, Sumioka M, et al. Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects. Dig Dis Sci 2002; 47: 675-81.
21. Pilotto A, Di Mario F, Franceschi M, Leandro G, Soffiati G, Scagnelli M, et al. Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers. Aliment Pharmacol Ther 1996; 10: 1021-7.
22. Kokkola A, Sipponen P, Rautelin H, Härkönen M, Kosunen TU, Haapiainen R, et al. The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 2002; 16: 515-20.
23. Ruiz B, Garay J, Correa P, Fontham ET, Bravo JC, Bravo LE, et al. Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection. Am J Gastroenterol 2001; 96: 3281-7.
24. Dobrilla G, Zancanella L, Amplatz S. The need for long-term treatment of peptic ulcer. Aliment Pharmacol Ther 1993; 7 (Suppl 2): 3-15.
25. Tytgat GN. Treatment of peptic ulcer. Digestion 1998; 59: 446-52.
26. Kuipers EJ, Thijs JC, Festen HP. The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 1995; 9 (Suppl 2): 59-69.
27. Kemppainen H, Raiha I, Sourander L. Clinical presentation of peptic ulcer in the elderly. Gerontology 1997; 43: 283-8.
28. Pilotto A, Franceschi M, Valerio G, Di Mario F, Leandro G. Helicobacter pylori infection in elderly patients with peptic ulcer. Age Ageing 1999; 28: 412-4.
29. Pilotto A, Franceschi M, DiMario F. Helicobacter pylori-associated peptic ulcer disease in elderly patients. Clin Geriatr 2000; 8: 49-58.
30. Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Compylobacter pylori. Lancet 1988; 2: 1437-42.
31. Hopkins RJ, Girardi LS, Turney EA. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology 1996; 110: 1244-52.
32. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis. Am J Gastroenterol 2004; 99: 1833-55.
33. Pilotto A, Franceschi M, Di Mario F, Leandro G, Bozzola L, Valerio G. The long-term clinical outcome of elderly patients with Helicobacter pylori-associated peptic ulcer disease. Gerontology 1998; 44: 153-8.
34. Pilotto A. Aging and upper gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18 (Suppl): 73-81.
35. Huang JQ, Sridhar S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet 2002; 359: 14-22.
36. Vergara M, Catalán M, Gisbert JP, Calvet X. Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users. Aliment Pharmacol Ther 2005; 21: 1411-8.
37. Pilotto A, Di Mario F, Franceschi M, Leandro G, Battaglia G, Germanà B, et al. Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. Aliment Pharmacol Ther 2000; 14: 1077-82.
38. Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007; 56: 772-81.
39. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991; 325: 1127-31.
40. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991; 325: 1132-6.
41. Lin JT, Wang LY, Wang JT, Wang TH, Yang CS, Chen CJ. A nested case-control study on the association between Helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan. Anticancer Res 1995; 15: 603-6.
42. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998; 115: 642-8.
43. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-9.
44. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004; 291: 187-94.
45. Lee CW, Rickman B, Rogers AB, Ge Z, Wang TC, Fox JG. Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. Cancer Res 2008; 68: 3540-8.
46. Romero-Gallo J, Harris EJ, Krishna U, Washington MK, Perez-Perez GI, Peek RM Jr. Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest 2008; 88: 328-36.
47. Lee YC, Lin JT, Wu HM, Liu TY, Yen MF, Chiu HM, et al. Cost-effectiveness analysis between primary and secondary preventive strategies for gastric cancer. Cancer Epidemiol Biomarkers Prev 2007; 16: 875-85.
48. Fock KM, Talley N, Moayyedi P, Hunt R, Azuma T, Sugano K, et al. Asia-Pacific consensus guidelines on gastric cancer prevention. J Gastroenterol Hepatol 2008; 23: 351-65.
49. Andersson SI, Hovelius B, Molstad S, Wadstrom T. Dyspepsia in general practice: psychological findings in relation to Helicobacter pylori serum antibodies. J Psychosom Res 1994; 38: 241-7.
50. Trespi E, Broglia F, Villani L, Luinetti O, Fiocca R, Solcia E. Distinct profiles of gastritis in dyspepsia subgroups. Their different clinical responses to gastritis healing after Helicobacter pylori eradication. Scand J Gastroenterol 1994; 29: 884-8.
51. Wyatt JI, Rathbone BJ, Sobala GM, Shallcross T, Heatley RV, Axon AT, et al. Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation. J Clin Pathol 1990; 43: 981-6.
52. Laheij RJ, Jansen JB, van de Lisdonk EH, Severens JL, Verbeek AL. Review article: symptom improvement through eradication of Helicobacter pylori in patients with non-ulcer dyspepsia. Aliment Pharmacol Ther 1996; 10: 843-50.
53. Jaakkimainen RL, Boyle E, Tudiver F. Is Helicobacter pylori associated with non-ulcer dyspepsia and will eradication improve symptoms? A meta-analysis. BMJ 1999; 319: 1040-4.
54. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, et al. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev 2006; 2: CD002096.
55. Pilotto A, Franceschi M, Leandro G, Bozzola L, Fortunato A, Rassu M, et al. Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter pylori infection in elderly patients. J Gastroenterol Hepatol 1999; 14: 468-75.
56. Catalano F, Branciforte G, Brogna A, Bentivegna C, Luca S, Terranova R, et al. Helicobacter pylori-positive functional dyspepsia in elderly patients: comparison of two treatments. Dig Dis Sci 1999; 44: 863-7.
57. Tytgat GN. Role of endoscopy and biopsy in the work up of dyspepsia. Gut 2002; 50 (Suppl 4): iv13-6.
58. Liou JM, Lin JT, Wang HP, Huang SP, Lee YC, Shun CT, et al. The optimal age threshold for screening upper endoscopy for uninvestigated dyspepsia in Taiwan, an area with a higher prevalence of gastric cancer in young adults. Gastrointest Endosc 2005; 61: 819-25.
59. Raghunath A, Hungin AP, Wooff D, Childs S. Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. BMJ 2003; 326: 737.
60. Pilotto A, Franceschi M, Rassu M, Bozzola L, Soffiati G, Valerio G. The influence of H. pylori infection on the efficacy of proton pump inhibitor treatment of esophagitis in elderly patients. Gut 2001; 49 (Suppl 2): A64-5.
61. Tefera S, Hatlebakk JG, Berstad A. The effect of Helicobacter pylori eradication on gastro-oesophageal reflux. Aliment Pharmacol Ther 1999; 13: 915-20.
62. Schenk BE, Kuipers EJ, Nelis GF, Bloemena E, Thijs JC, Snel P, et al. Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy. Gut 2000; 46: 615-21.
63. Gisbert JP, Pajares JM. Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. Helicobacter 2004; 9: 347-68.
64. Abdalla AM, Sordillo EM, Hanzely Z, Perez-Perez GI, Blaser MJ, Holt PR, et al. insensitivity of the CLOtest for H. pylori, especially in the elderly, Gastroenterology 1998; 115: 243-4.
65. Pilotto A, Franceschi M, Leandro G, Rassu M, Zagari RM, Bozzola L, et al. Noninvasive diagnosis of Helicobacter pylori infection in older subjects: comparison of the 13C-urea breath test with serology. J Gerontol A Biol Sci Med Sci 2000; 55: M163-7.
66. Salles-Montaudon N, Dertheil S, Broutet N, Broutet N, Gras N, Monteiro L, et al. Detecting Helicobacter pylori infection in hospitalized frail elderly patients: the challenge. J Am Geriatr Soc 2002; 50: 1674-80.
67. Gomollón F, Ducons JA, Santolaria S, Lera Omiste I, Guirao R, Ferrero M, et al. Breath test is very reliable for diagnosis of Helicobacter pylori infection in real clinical practice. Dig Liver Dis 2003; 35: 612-8.
68. Salles-Montaudon N, Dertheil S, Broutet N, Gras N, Monteiro L, De Mascarel A, et al. Detecting Helicobacter pylori infection in hospitalized frail older patients: the challenge. J Am Geriatr Soc 2002; 50: 1674-80.
69. Pilotto A, Rassu M, Leandro G, Franceschi M, Di Mario F; for GISU. Prevalence of Helicobacter pylori resistance to antibiotics in northeast Italy: a multicentre study. Dig Liver Dis 2000; 32: 763-8.
70. Moshkowitz M, Brill S, Konikoff FM, Reif S, Arber N, Halpern Z. The efficacy of omeprazole-based short-term triple therapy in Helicobacter pylori-positive patients with dyspepsia. J Am Geriatr Soc 1999; 47: 720-2.
71. Dore MP, Maragkoudakis E, Pironti A, Tadeu V, Tedde R, Realdi G, et al. Twice-a-day quadruple therapy for eradication of Helicobacter pylori in the elderly. Helicobacter 2006; 11: 52-5.
72. Zullo A, Gatta L, De Francesco V, Hassan C, Ricci C, Bernabucci V, et al. High rate of Helicobacter pylori eradication with sequential therapy in elderly patients with peptic ulcer: a prospective controlled study. Aliment Pharmacol Ther 2005; 21: 1419-24.
73. Ammon S, Treiber G, Kees F, Klotz U. Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. Aliment Pharmacol Ther 2000; 14: 759-66.
74. Pilotto A, Franceschi M, Leandro G, Bozzola L, Rassu M, Soffiati G, et al. Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole. Aliment Pharmacol Ther 2001; 15: 1031-6.
75. Pilotto A, Leandro G, Franceschi M, Rassu M, Bozzola L, Furlan F, et al. The effect of antibiotic resistance on the outcome of three 1-week triple therapies against Helicobacter pylori. Aliment Pharmacol Ther 1999; 13: 667-73.
76. Pilotto A, Di Mario F, Franceschi M. Efficacy of one-week triple therapies with low-dose rabeprazole and clarithromycin plus standard-dose amoxicillin or tinidazole for the cure of H. pylori infection in elderly patients. Gut 2001; 49 (Suppl 2): A95.