Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 2, 2009, Pages 251-256

  Occhiuto, Francesco ^a   Pino, Annalisa ^a   Palumbo, Dora Rita ^a   Samperi, Stefania ^a   De Pasquale, Rita ^a   Sturlese, Emanuele ^b   Circosta, Clara ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Calcium antagonists; Isolated human myometrium; Spasmolytic activity; Uterus contractility; Valepotriates; Valeriana officinalis

Indexed keywords

NIFEDIPINE; VALEPOTRIATE; VALERIAN;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DYSMENORRHEA; HUMAN; HUMAN TISSUE; MYOMETRIUM; UTERUS CONTRACTION; UTERUS RELAXATION;

EID: 59049101630     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.02.0016     Document Type: Article

References (23)

1. Houghton PJ. The biological activity of valerian and related plants. J Ethnopharmacol 1988; 22: 121-142.
2. Klich R. Behaviour disorders in childhood and their therapy. Med Welt 1975; 26: 1251-1254.
3. Hoffman D. The complete Illustrated Holistic Herbal. Rockport, MA: Element Books Inc., 1996.
4. Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: William Morrow and Company Inc., 1999.
5. Goppel M, Franz G. Stability control of valerian ground material and extracts: a new HPLC method for the routine quantification of valerenic acids and lignans. Pharmazie 2004; 59: 446-452.
6. Wagner H et al. Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products. Planta Med 1980; 39: 358-365.
7. Schneider G, Willems M. Erkenntnisse uber die Abbauprodukte der Valepotriate aus Kentranthus ruber (L.) DC. Arch Pharm (Weinheim) 1982; 315: 691-697.
8. Veith J et al. Einfluss einiger Abbauprodukte von valepotriaten auf die Motilitat Licht-Dunkel Synchronisiester Mause. Planta Med 1986; 52: 179-183.
9. Wagner H, Jurcic K. On the spasmolytic activity of Valeriana extracts. Planta Med 1979; 37: 84-86.
10. Von Eickstedt K-W. Die Beeinflussung der Alkohol-Wirkung durch Valepotriate. Arzneimittel Forschung 1969; 19: 995-997.
11. Circosta C et al. Biological and analytical characterization of two extracts from Valeriana officinalis. J Ethnopharmacol 2007; 112: 361-367.
12. Stahl E, Schild W. Thin layer chromatography for determination of pharmacopeia drugs. Valerian root, valerian radix. Arzeneimittel-Forschung 1969; 19: 314-316.
13. Stahl E, Schild W. Über die Verbreitung der äquilibrierend wirkenden valepotriate in der familie der Valerianaceae. Phytochemistry 1971; 10: 147-153.
14. Wagner H, Bladt S. Plant drug analysis. Berlin: Springer Verlag, 1996.
15. Bos R et al. Analytical aspects of phytotherapeutic valerian preparations Phytochem Anal 1996; 7: 143-151.
16. Fuzzati N et al. Isolation of antifungal valepotriates from Valeriana capense and the search for valepotriates in crude Valerianaceae extracts. Phytochem Anal 1996; 7: 76-85.
17. Thies PW. Die konstitution der Valepotriate- Mitteilung uber die Wirkstoffe des Baldrians. Tetrahedron 1968; 24: 313-347.
18. Popov SS, Handjieva N. Mass spectrometry of valepotriates. Biomed Mass Spectrom 1979; 6: 124-128.
19. Lie YL et al. Relaxation of isolated human myometrial tissue by beta 2-adrenergic receptors but not beta 1-adrenergic receptors. Am J Obstet Gynecol 1998; 179: 895-898.
20. Kiriyama M et al. Prostaglandin-endoperoxide H synthase-2 expression and activity increases with term labour in human chorion. Am J Physiol 1997; 272: E832-840.
21. Poli E et al. Characterization of the spontaneous motor activity of the isolated human pregnant myometrium. Pharmacol Res 1990; 22: 115-124.
22. Bolton TB. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 1979; 59: 606-718.
23. Hazelhoff B et al. Antispasmodic effects of Valeriana compounds: an in vivo and in vitro study on the guinea-pig ileum. Arch Int Pharmacodyn Ther 1982; 257: 274-287.