A photoreactive ruthenium(II) complex tethered to a guanine-containing oligonucleotide: A biomolecular tool that behaves as a seppuku molecule

Angewandte Chemie - International Edition

Volumn 48, Issue 6, 2009, Pages 1122-1125

  Le Gac, Stéphane ^a   Rickling, Stéphane ^a   Gerbaux, Pascal ^b   Defrancq, Eric ^c   Moucheron, Cécile ^a   Kirsch De Mesmaeker, Andrée ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

^c UNIVERSITÉ JOSEPH FOURIER   (France)

Author keywords

Antisense agents; Electron transfer; Oligonucleotides; Photochemistry; Ruthenium

Indexed keywords

ELECTRON TRANSITIONS; GENETIC ENGINEERING; NUCLEOTIDES; OLIGONUCLEOTIDES; PHOTOREACTIVITY; POSITIVE IONS; RUTHENIUM;

ANTISENSE AGENTS; ATTRACTIVE STRATEGIES; BIO-MOLECULAR; COMPLEMENTARY STRANDS; ELECTRON TRANSFER; GENE-SILENCING; PHOTO EFFECTS; PHOTO-CROSS-LINKED; PHOTOCHEMISTRY; SELF INHIBITIONS;

RUTHENIUM COMPOUNDS;

GUANINE; OLIGONUCLEOTIDE; RUTHENIUM;

ARTICLE; CHEMISTRY; LUMINESCENCE; MASS SPECTROMETRY; SYNTHESIS;

GUANINE; LUMINESCENCE; MASS SPECTROMETRY; OLIGONUCLEOTIDES; RUTHENIUM;

EID: 59049101307     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200804503     Document Type: Article

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12. (G) was chosen such as not being directly accessible by the metal complex without a folding of the strand.
13. 0, indicates a protection of the excited state from the aqueous phase, which suggests that the Ru-ODN adopts a secondary structure, see: D. García-Fresnadillo, O. Lentzen, I. Ortmans, E. Defrancq, A. Kirsch-De Mesmaeker, Dalton Trans. 2005, 852-856.
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15. 32P-labeled.
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