Use of remote centralized raters via live 2-way video in a multicenter clinical trial for schizophrenia

Journal of Clinical Psychopharmacology

Volumn 28, Issue 6, 2008, Pages 691-693

  Shen, Joan ^a   Kobak, Kenneth A ^b   Zhao, Yonggang ^a   Alexander, Madeline M ^b   Kane, John M ^c,d  

^a PFIZER INC   (United States)

^b MedAvante Inc   (United States)

^c ZUCKER HILLSIDE HOSPITAL   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLANZAPINE; PLACEBO; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EFFECT SIZE; HUMAN; INTERNAL CONSISTENCY; INTERRATER RELIABILITY; MAJOR CLINICAL STUDY; METHODOLOGY; MULTICENTER STUDY; PATIENT PARTICIPATION; PERSONNEL; PHASE 2 CLINICAL TRIAL; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHIZOPHRENIA; SCORING SYSTEM; VIDEOCONFERENCING; ADOLESCENT; AGED; COMPARATIVE STUDY; MIDDLE AGED; OBSERVER VARIATION; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; REPRODUCIBILITY; TELEMEDICINE; TIME; TREATMENT OUTCOME; UNITED STATES;

ADOLESCENT; ADULT; AGED; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; HUMANS; MIDDLE AGED; OBSERVER VARIATION; PSYCHIATRIC STATUS RATING SCALES; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TELEMEDICINE; TIME FACTORS; TREATMENT OUTCOME; UNITED STATES; VIDEOCONFERENCING; YOUNG ADULT;

EID: 59049100877     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31818c9ba3     Document Type: Article

References (8)

1. Khan A, Kolts RL, Rapaport MH, et al. Magnitude of placebo response and drug-placebo differences across psychiatric disorders. Psychol Med. 2005;35:743-749.
2. Kobak KA, Kane JM, Thase ME, et al. Why do clinical trials fail? The problem of measurement error in clinical trials: time to test new paradigms? J Clin Psychopharmacol. 2007;27:1-5.
3. Kobak KA, Engelhardt N, Williams JB, et al. Rater training in multicenter clinical trials: issues and recommendations. J Clin Psychopharmacol. 2004;24:113-117.
4. Kane J, Schmidt J, Kobak KA. The use of centralized raters in multi- center clinical trials for schizophrenia. Presented at the International Society for CNS Clinical Trials and Methodology, 3rd Annual Scienti?c Congress; Febuary 20-21, 2007; Washington, DC.
5. Zarate CA Jr, Weinstock L, Cukor P, et al. Applicability of telemedicine for assessing patients with schizophrenia: acceptance and reliability. J Clin Psychiatry. 1997;58:22-25.
6. Yoshino A, Shigemura J, Kobayashi Y, et al. Telepsychiatry: assessment of televideo psychiatric interview reliability with present- and next- generation internet infrastructures. Acta Psychiatr Scand. 2001;104: 223-226.
7. Alphs LD. Historical perspective on drug-placebo differences: implica- tions for future trial design. Presented at the International Society for CNS Methodology Mid-Year Conference; September 17-18, 2007; Brussels, Belgium.
8. Schoemaker JH, Gaur R, Berkowitz L, et al. Expert rater assisted score evaluation (ERASE): a new method to enhance signal detection in randomized, placebo-controlled, clinical trials. Presented at the International Society for CNS Trials Methodology 4th Annual Meeting; Febuary 25-26, 2008; Washington, DC.