Leukopenia and neutropenia after intoxication with diphenhydramine (nytol) during clozapine treatment

Journal of Clinical Psychopharmacology

Volumn 28, Issue 6, 2008, Pages 706-707

  Charbonneau, Karine ^a   Landry, Pierre ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLONAZEPAM; CLOZAPINE; DIPHENHYDRAMINE; GABAPENTIN; RISPERIDONE; VALPROATE SEMISODIUM; HYPNOTIC SEDATIVE AGENT; NEUROLEPTIC AGENT;

ADULT; BLOOD EXAMINATION; CASE REPORT; DRUG INTOXICATION; DRUG RECHALLENGE; HUMAN; LETTER; LEUKOCYTE COUNT; LEUKOPENIA; MALE; NEUTROPENIA; NEUTROPHIL COUNT; POLYPHARMACY; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; SCHIZOPHRENIA; TREATMENT WITHDRAWAL; BLOOD; CHEMICALLY INDUCED DISORDER; MIDDLE AGED; PARANOID SCHIZOPHRENIA;

ANTIPSYCHOTIC AGENTS; CLOZAPINE; DIPHENHYDRAMINE; HUMANS; HYPNOTICS AND SEDATIVES; LEUKOPENIA; MALE; MIDDLE AGED; NEUTROPENIA; SCHIZOPHRENIA, PARANOID;

EID: 59049084558     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31818d7e78     Document Type: Letter

References (11)

1. Kane J, Honigfeld G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorproma- zine. Arch Gen Psychiatry. 1988;45:789-796.
2. Sénéchal A, Landry P, Deschamps R, et al. Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs. Encephale. 2002;28:567-569.
3. Munro J, O'Sullivan D, Andrews C, et al. Ac- tively monitoring of 12760 clozapine recipients in the UK and Ireland: beyond pharmacovi- gilance. Br J Psychiatry. 1999;175:576-580.
4. Bhanji NH, Margolese HC, Chouinard G, et al. Late-onset agranulocytosis in a patient with schizophrenia after 17 months of clo-zapine treatment. J Clin Psychopharmacol. 2003;23:522-523.
5. Small JG, Weber MC, Klapper MH, et al. Re- challenge of late-onset neutropenia with cloza- pine. J Clin Psychopharmacol. 2005;25:185-186.
6. Dunk LR, Annan LJ, Andrews CD. Rechal-lenge with clozapine following leucopenia or neutropenia during previous therapy. Br J Psychiatry. 2006;188:255-263.
7. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonche- motherapy drugs. Ann Intern Med. 2007;146: 657-665.
8. Godleski LS, Sernyak MJ. Agranulocytosis after addition of risperidone to clozapine treatment. Am J Psychiatry. 1996;153:735-736.
9. Pantelis C, Adesanya A. Increased risk of neutropenia and agranulocytosis with sodium valproate used adjunctively with clozapine. Aust NZ Psychiatry. 2001;35:544-545.
10. George TP, Innamorato L, Sernak M, et al. Leukopenia associated with addition of paroxetine to clozapine. J Clin Psychiatry. 1998;59:31.
11. Usiskin SI, Nicolson R, Lenane M, et al. Re- treatment with clozapine after erythromycin- induced neutropenia. Am J Psychiatry. 2000; 157:1021.