-
1
-
-
84898690661
-
-
Punt CJ, Koopman M, Douma J, et al. Sequential compared to combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC): a Dutch Colorectal Cancer Group (DCCG) phase III study. J Clin Oncol 2007; 25(18 suppl):166s (Abstract 4012).
-
Punt CJ, Koopman M, Douma J, et al. Sequential compared to combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC): a Dutch Colorectal Cancer Group (DCCG) phase III study. J Clin Oncol 2007; 25(18 suppl):166s (Abstract 4012).
-
-
-
-
2
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, André T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22:229-37.
-
(2004)
J Clin Oncol
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
André, T.2
Achille, E.3
-
3
-
-
0028175144
-
Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
-
Buroker TR, O'Connell MJ, Wieand HS, et al. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 1994; 12:14-20.
-
(1994)
J Clin Oncol
, vol.12
, pp. 14-20
-
-
Buroker, T.R.1
O'Connell, M.J.2
Wieand, H.S.3
-
4
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
5
-
-
84898695743
-
-
Skillings JR, Johnson DH, Miller K, et al. Arterial thrombotic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy. J Clin Oncol 2005; 23(16 suppl):196s (Abstract 3019).
-
Skillings JR, Johnson DH, Miller K, et al. Arterial thrombotic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy. J Clin Oncol 2005; 23(16 suppl):196s (Abstract 3019).
-
-
-
-
6
-
-
42949149159
-
-
Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxali- platin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study [published erratum appears in: J Clin Oncol 2008; 26:3110]. J Clin Oncol 2008; 26:2013-9.
-
Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxali- platin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study [published erratum appears in: J Clin Oncol 2008; 26:3110]. J Clin Oncol 2008; 26:2013-9.
-
-
-
-
7
-
-
62449211422
-
The safety of long-term bevacizumab use: Results from the BRiTE observational cohort study (OCS)
-
15 suppl):203s Abstract 4103
-
Purdie DM, Berlin JD, Flynn PJ, et al. The safety of long-term bevacizumab use: results from the BRiTE observational cohort study (OCS). J Clin Oncol 2008; 26(15 suppl):203s (Abstract 4103).
-
(2008)
J Clin Oncol
, pp. 26
-
-
Purdie, D.M.1
Berlin, J.D.2
Flynn, P.J.3
-
8
-
-
56749169353
-
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
-
Epub ahead of print
-
Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 2008 [Epub ahead of print].
-
(2008)
J Clin Oncol
-
-
Grothey, A.1
Sugrue, M.M.2
Purdie, D.M.3
-
9
-
-
44449165600
-
Safety and effectiveness of bevacizumab (BV) and chemotherapy (CT) in elderly patients with metastatic colorectal cancer (mCRC): Results from the BRiTE prospective cohort study
-
Presented at: January 25-27, Orlando, FL. Abstract 454
-
Kozloff M, Sugrue M, Berlin J, et al. Safety and effectiveness of bevacizumab (BV) and chemotherapy (CT) in elderly patients with metastatic colorectal cancer (mCRC): results from the BRiTE prospective cohort study. Presented at: the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL. Abstract 454.
-
(2008)
the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium
-
-
Kozloff, M.1
Sugrue, M.2
Berlin, J.3
-
10
-
-
36048960109
-
Randomized, controlled trial of irino- tecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
-
Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irino- tecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007; 25:4779-86.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4779-4786
-
-
Fuchs, C.S.1
Marshall, J.2
Mitchell, E.3
-
11
-
-
39149108869
-
Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
-
Fuchs, CS, Marshall J, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol 2008; 26:689-90.
-
(2008)
J Clin Oncol
, vol.26
, pp. 689-690
-
-
Fuchs, C.S.1
Marshall, J.2
Barrueco, J.3
-
12
-
-
24644457747
-
Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
-
Colucci G, Gebbia V, Paoletti G, et al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 2005; 23:4866-75.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4866-4875
-
-
Colucci, G.1
Gebbia, V.2
Paoletti, G.3
-
13
-
-
0036362181
-
Why the epidermal growth factor receptor? The rationale for cancer therapy
-
Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002; 7(suppl 4):2-8.
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 4
, pp. 2-8
-
-
Baselga, J.1
-
14
-
-
0036817040
-
Epithelial growth factor receptor interacting agents
-
Baselga J, Albanell J. Epithelial growth factor receptor interacting agents. Hematol Oncol Clin North Am 2002; 16:1041-63.
-
(2002)
Hematol Oncol Clin North Am
, vol.16
, pp. 1041-1063
-
-
Baselga, J.1
Albanell, J.2
-
15
-
-
0028955388
-
Epidermal growth factor-related pep- tides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, et al. Epidermal growth factor-related pep- tides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19:183-232.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
-
16
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
Abstract 7
-
Saltz LB, Rubin M, Hochester H, et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001; 20:3a (Abstract 7).
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Saltz, L.B.1
Rubin, M.2
Hochester, H.3
-
17
-
-
0001407135
-
Single agent IMC-C225 (ErbituxTM) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
Abstract 504
-
Saltz L, Meropol NJ, Loeher PJ, et al. Single agent IMC-C225 (ErbituxTM) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002; 21: (Abstract 504).
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Saltz, L.1
Meropol, N.J.2
Loeher, P.J.3
-
18
-
-
3242720345
-
Cetuximab monotherapy and cetux- imab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetux- imab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-45.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
19
-
-
11344268358
-
Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor
-
Camp ER, Summy J, Bauer TW, et al. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor. Clin Cancer Res 2005; 11:397-405.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 397-405
-
-
Camp, E.R.1
Summy, J.2
Bauer, T.W.3
-
20
-
-
6344272498
-
ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis
-
Abstract 3511
-
Hecht JR, Patnaik A, Malik I, et al. ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis. Proc Am Soc Clin Oncol 2004; 22:248 (Abstract 3511).
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
, pp. 248
-
-
Hecht, J.R.1
Patnaik, A.2
Malik, I.3
-
21
-
-
84898700140
-
-
Berlin J, Neubauer M, Swanson P, et al. Panitumumab antitumor activity in patients (pts) with metastatic colorectal cancer (mCRC) expressing ≥10% epidermal growth factor receptor (EGFr). J Clin Oncol 2006; 24(18 suppl):158s (Abstract 3548).
-
Berlin J, Neubauer M, Swanson P, et al. Panitumumab antitumor activity in patients (pts) with metastatic colorectal cancer (mCRC) expressing ≥10% epidermal growth factor receptor (EGFr). J Clin Oncol 2006; 24(18 suppl):158s (Abstract 3548).
-
-
-
-
22
-
-
34147103678
-
Open-label phase III trial of panitu- mumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitu- mumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25:1658-64.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
23
-
-
84898690423
-
-
Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinote- can and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
-
Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinote- can and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
-
-
-
-
24
-
-
84898695801
-
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Cetuximab plus 5-FU/FA/oxali- platin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study. J Clin Oncol 2007; 25(18 suppl):172s (Abstract 4035).
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Cetuximab plus 5-FU/FA/oxali- platin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study. J Clin Oncol 2007; 25(18 suppl):172s (Abstract 4035).
-
-
-
-
25
-
-
33646227448
-
Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
-
Tonra JR, Deevi DS, Corcoran E, et al. Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin Cancer Res 2006; 12:2197-207.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2197-2207
-
-
Tonra, J.R.1
Deevi, D.S.2
Corcoran, E.3
-
26
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
-
Saltz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007; 25:4557-61.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
-
27
-
-
46049113331
-
An updated analysis of safety and efficacy of oxali- platin (Ox)/bevacizumab (bev) +/- panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE)
-
Presented at: January 25-27, Orlando, FL. Abstract 273
-
Hecht JR, Mitchell E, Chidiac T, et al. An updated analysis of safety and efficacy of oxali- platin (Ox)/bevacizumab (bev) +/- panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE). Presented at: the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL. Abstract 273.
-
(2008)
the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
28
-
-
84898702208
-
-
Punt CJ, Tol J, Rodenburg CJ, et al. Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorec- tal cancer (ACC), the CAIRO2 study if the Dutch Colorectal Cancer Group (DCCG). J Clin Oncol 2008; 26(15 suppl):180s (Abstract LBA4011).
-
Punt CJ, Tol J, Rodenburg CJ, et al. Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorec- tal cancer (ACC), the CAIRO2 study if the Dutch Colorectal Cancer Group (DCCG). J Clin Oncol 2008; 26(15 suppl):180s (Abstract LBA4011).
-
-
-
-
29
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25:3230-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
30
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A, Bachet JB, Boige V, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008; 26:374-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
-
31
-
-
42649145667
-
Wild-type KRAS is required for panitu- mumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitu- mumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
32
-
-
84898702155
-
-
Van Cutsem E, Lang I, D'haens G, et al. KRAS status and efficacy in the first- line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience. J Clin Oncol 2008; 26(15 suppl):5s (Abstract 2).
-
Van Cutsem E, Lang I, D'haens G, et al. KRAS status and efficacy in the first- line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience. J Clin Oncol 2008; 26(15 suppl):5s (Abstract 2).
-
-
-
-
33
-
-
84898696842
-
-
Bokemeyer C, Bondarenko I, Hartmann JT, et al. KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: the OPUS experience. J Clin Oncol 2008; 26(15 suppl):178s (Abstract 4000).
-
Bokemeyer C, Bondarenko I, Hartmann JT, et al. KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: the OPUS experience. J Clin Oncol 2008; 26(15 suppl):178s (Abstract 4000).
-
-
-
|