Development of Integrated Testing Strategies for REACH: Motivation, Background and Introduction

ATLA Alternatives to Laboratory Animals

Volumn 36, Issue 1_suppl, 2008, Pages i-iii

  Cronin, Mark T D ^a   Garrod, John F ^b   Balls, Michael ^c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b Chemicals and Nanotechnologies Division   (United Kingdom)

^c RUSSELL AND BURCH HOUSE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INORGANIC COMPOUND; ORGANIC COMPOUND;

ANIMAL; ANIMAL TESTING ALTERNATIVE; COMPUTER SIMULATION; CULTURE TECHNIQUE; DANGEROUS GOODS; EDITORIAL; EXPERIMENTAL ANIMAL; LEGAL ASPECT; METHODOLOGY; STANDARD; TOXICITY TESTING; UNITED KINGDOM;

ANIMAL TESTING ALTERNATIVES; ANIMALS; ANIMALS, LABORATORY; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; GREAT BRITAIN; HAZARDOUS SUBSTANCES; INORGANIC CHEMICALS; ORGANIC CHEMICALS; TOXICITY TESTS;

MLCS; MLOWN;

EID: 58949097442     PISSN: 02611929     EISSN: 26323559     Source Type: Journal    
DOI: 10.1177/026119290803601s01     Document Type: Editorial

References (16)

1. European Commission (2001). White Paper —Strategy for a Future Chemicals Policy. COM(20010) 88 Final, 321pp. Brussels, Belgium: Commission of the European Communities.
2. European Commission (2006). Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official Journal of the European Union L396/1, 1–849.
3. Balls M. & Combes R. (eds) (2006). The REACH system: Scientific and animal welfare implications of EU legislation on chemicals testing. ATLA 34, Suppl. 1, 1–158.
4. van der Jagt K., Munn S., Tørsløv J. & de Bruijn J. (2004). Alternative Approaches can Reduce the Use of Test Animals under REACH. Addendum to the Report “Assessment of Additional Testing Needs under REACH. Effects of (Q)SARs, Risk based Testing and Voluntary Industry Initiatives. JRC Report EUR 21405 EN, 25pp. Ispra, Italy: European Commission Joint Research Centre.
5. Anon. (2005). Report on the Review of the Status of the Development of Alternatives to using Animals in Chemical Safety Testing and Identification of New Areas for Development or Research in the Context of the Proposed REACH Regulation, prepared by Liverpool John Moores University and The Fund for the Replacement of Animals in Medical Experiments (FRAME), 176pp. Available at: http://www.defra.gov.uk/science/Project_Data/DocumentLibrary/CB01067/CB01067_2795_FRA.pdf (Accessed 05.08.08).
6. Fabjan E., Hulzebos E., Mennes W. & Piersma A.H. (2006). A category approach for reproductive effects of phthalates. Critical Reviews in Toxicology 36, 695–726.
7. Enoch S.J., Madden J.C. & Cronin M.T.D. (2008) Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach. SAR & QSAR in Environmental Research 19, in press.
8. Gerberick F., Aleksic M., Basketter D., Casati S., Karlberg A-T., Kern P., Kimber I. Lepoittevin J.P., Natsch A., Ovigne J.M., Rovida C., Sakaguchi H. & Schultz T. (2008). Chemical reactivity measurement and the predictive identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64. ATLA 36, 215–242.
9. The DEFRA LINK Alternatives to Animal Testing for Chemical Risk Assessment Project. Available at: www.inchemicotox.org (Accessed 05.08.08).
10. European Union 6th Framework ReProTect Integrated Project. Available at: http://www.reprotect.eu/ (Accessed 05.08.08).
11. European Union 6th Framework AcuteTox Integrated Project. Available at: http://www.acutetox.org/ (Accessed 05.08.08).
12. European Union 6th Framework NoMiracle Integrated Project. Available at: http://nomiracle.jrc.it/default.aspx (Accessed 05.08.08).
13. European Union 6th Framework OSIRIS Integrated Project. Available at: http://www.osiris.ufz.de/ (Accessed 05.08.08).
14. European Chemical Bureau Computational Toxicology Group web site. Available at: http://ecb.jrc.it/qsar/ (Accessed 05.08.08).
15. General information on the OECD (Q)SAR Application Toolbox and download options. Available at: http://www.oecd.org/document/23/0,3343,en_2649_34379_33957015_1_1_1_1,00.html (Accessed 05.08.08).
16. European Chemical Industry Council Long-range Research Initiative (CEFIC-LRi). Available at: http://www.cefic-lri.org/ (Accessed 05.08.08).