Exposed: The Genetic Underpinnings of Ulcerative Colitis Relative to Crohn's Disease

Gastroenterology

Volumn 136, Issue 2, 2009, Pages 396-399

  Brant, Steven R ^a  

^a Institute for Cell Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; DEATH RECEPTOR 3; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VASCULAR ENDOTHELIAL GROWTH INHIBITOR;

CHROMOSOME 16; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EDITORIAL; ENTERITIS; FAMILY HISTORY; GENE; GENETIC LINKAGE; GENOTYPE; HUMAN; INTESTINE RESECTION; PATHOPHYSIOLOGY; PHENOTYPE; PREGNANCY OUTCOME; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

EID: 58949087690     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.12.016     Document Type: Editorial

References (11)

1. Orholm M., Iselius L., Sorensen T.I., et al. Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis. BMJ 306 (1993) 20-24
2. Brant S.R., and Shugart Y.Y. Inflammatory bowel disease gene hunting by linkage analysis: rationale, methodology, and present status of the field. Inflamm Bowel Dis 10 (2004) 300-311
3. Anderson C.A., Massey D.C.O., Barrett J.C., et al. Investigation of Crohn's disease risk loci in Ulcerative Colitis further defines their molecular relationship. Gastroenterology 136 (2009) 523-529
4. Cho J.H., and Weaver C.T. The genetics of inflammatory bowel disease. Gastroenterology 133 (2007) 1327-1339
5. Fisher S.A., Tremelling M., Anderson C.A., et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 40 (2008) 710-712
6. Raelson J.V., Little R.D., Ruether A., et al. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A 104 (2007) 14747-14752
7. Franke A., Balschun T., Karlsen T.H., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40 (2008) 1319-1323
8. Kugathasan S., Baldassano R.N., Bradfield J.P., et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet 40 (2008) 1211-1215
9. Barrett J.C., Hansoul S., Nicolae D.L., et al. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease. Nat Genet 40 (2008) 955-962
10. Franke A., Balschun T., Karlsen T.H., et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 40 (2008) 713-715
11. Silverberg M.S., Cho J.H., Rioux J.D., et al. Ulcerative colitis loci on chromosomes 1p36 and 12q15 identified by genome-wide association study. Nat Genet (2009) Jan 4; [Epub ahead of print]