Multipoint lods provide reliable linkage evidence despite unknown limiting distribution: Type I error probabilities decrease with sample size for multipoint lods and mods

Genetic Epidemiology

Volumn 32, Issue 8, 2008, Pages 800-815

  Hodge, Susan E ^a,b,c   Rodriguez Murillo, Laura ^c   Strug, Lisa J ^d   Greenberg, David A ^a,b,c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b New York Presbyterian Columbia University Medical Center   (United States)

^c The University of Toronto ^*  (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Evidential paradigm; Maximization; Multipoint mapping; Pure likelihood

Indexed keywords

ANALYTICAL ERROR; ARTICLE; COMPUTER SIMULATION; GENE MAPPING; GENETIC MODEL; LINKAGE ANALYSIS; PROBABILITY; RELIABILITY; SAMPLE SIZE; STATISTICAL ANALYSIS; STATISTICAL DISTRIBUTION; BIOLOGICAL MODEL; CHROMOSOME MAP; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; HUMAN; LABORATORY DIAGNOSIS; METHODOLOGY; REPRODUCIBILITY; STATISTICAL MODEL;

CHROMOSOME MAPPING; COMPUTER SIMULATION; FALSE POSITIVE REACTIONS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; LOD SCORE; MODELS, GENETIC; MODELS, STATISTICAL; PROBABILITY; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SAMPLE SIZE;

EID: 58949086547     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20350     Document Type: Article

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