Pulmonary capillaritis as a manifestation of acute humoral allograft rejection following infant lung transplantation

American Journal of Transplantation

Volumn 9, Issue 2, 2009, Pages 409-412

  Astor, T L ^a   Galantowicz, M ^a   Phillips, A ^a   Palafox, J ^a   Baker, P ^a  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Complement C4d; HLA antibodies; Humoral rejection; Immunofluorescence; Immunohistochemistry; Lung transplantation

Indexed keywords

AMPHOTERICIN; AZATHIOPRINE; BASILIXIMAB; CEFEPIME; COMPLEMENT COMPONENT C4D; COTRIMOXAZOLE; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; HLA ANTIBODY; ITRACONAZOLE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RITUXIMAB; TACROLIMUS; TOBRAMYCIN; VANCOMYCIN;

ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE TITRATION; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INFANT; INFECTION; INFECTION PREVENTION; LUNG ALVEOLUS PROTEINOSIS; LUNG BIOPSY; LUNG CAPILLARY; LUNG INFECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MALE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REPEATED DRUG DOSE; SEROLOGY; SINGLE DRUG DOSE; THORAX RADIOGRAPHY;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; ANTINEOPLASTIC AGENTS; CAPILLARIES; GRAFT REJECTION; HUMANS; INFANT; LUNG; LUNG DISEASES; LUNG TRANSPLANTATION; MALE; POSTOPERATIVE COMPLICATIONS; VASCULITIS;

EID: 58849148937     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02467.x     Document Type: Article

References (15)

1. Badesch DB, Zamora M, Fullerton D et al. Pulmonary capillaritis: A possible histologic form of acute pulmonary allograft rejection. J Heart Lung Transplant 1998 17 : 415 422.
2. Astor TL, Weill D, Cool C, Teitelbaum I, Schwarz MI, Zamora MR. Pulmonary capillaritis in lung transplant recipients: Treatment and effect on allograft function. J Heart Lung Transplant 2005 24 : 2091 2097.
3. Yousem SA, Berry GJ, Cagle PT et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung rejection study group. J Heart Lung Transplant 1996 15 : 1 15.
4. Magro CM, Deng A, Pope-Harman A et al. Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: A hypothesis. Transplantation 2002 74 : 1273 1280.
5. Magro, CM, Klinger DM, Adams PW et al. Evidence that humoral allograft rejection in lung transplant patients is not histocompatibility antigen-related. Am J Transplant 2003 3 : 1264 1272.
6. Ionescu, DN, Girnita AL, Zeevi A et al. C4d deposition in lung allografts is associated with circulating anti-HLA alloantibody. Transpl Immunol 2005 15 : 63 68.
7. Miller, GG, Destarac L, Zeevi A et al. Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid. Am J Transplant 2004 4 : 1323 1330.
8. Abraham, KA, Brown C, Conlon PJ et al. Plasmapheresis as rescue therapy in accelerated acute humoral rejection. J Clin Apher 2003 18 : 103 110.
9. Bittner, HB, Dunitz J, Hertz M, Bolman MR, 3rd., Park SJ. Hyperacute rejection in single lung transplantation - Case report of successful management by means of plasmapheresis and antithymocyte globulin treatment. Transplantation 2001 71 : 649 651.
10. Faguer, S, Kamar N, Guilbeaud-Frugier C et al. Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 2007 83 : 1277 1280.
11. Kaczmarek, I, Deutsch MA, Sadoni S et al. Successful management of antibody-mediated cardiac allograft rejection with combined immunoadsorption and anti-CD20 monoclonal antibody treatment: Case report and literature review. J Heart Lung Transplant 2007 26 : 511 515.
12. Keren, A, Hayes HM, O'Driscoll G. Late humoral rejection in a cardiac transplant recipient treated with the anti-CD20 monoclonal antibody rituximab. Transplant Proc 2006 38 : 1520 1522.
13. Sibley, RK, Berry GJ, Tazelaar HD et al. The role of transbronchial biopsies in the management of lung transplant recipients. J Heart Lung Transplant 1993 12 : 308 324.
14. Takemoto, SK, Zeevi A, Feng S et al. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant 2004 4 : 1033 1041.
15. Stewart, S, Fishbein MC, Snell GI et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 2007 26 : 1229 1242.