메뉴 건너뛰기




Volumn 37, Issue SUPPL. 1, 2009, Pages

Better translation from bench to bedside: Breakthroughs in the individualized treatment of cancer

Author keywords

Biological materials banking; Biomarker; Breast cancer; Clinical trial design; Gene expression profiling; HER2; Individualized treatment; Lapatinib; Mammaprint; Trastuzumab

Indexed keywords

LAPATINIB; TRASTUZUMAB; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

EID: 58849145235     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181921598     Document Type: Article
Times cited : (10)

References (49)
  • 1
  • 2
    • 67749115703 scopus 로고
    • Available at:, National Cancer Institute. Office of Government and Congressional Relations. The National Cancer Act of
    • Available at: http://legislative.cancer.gov/ history/phsa/1971. National Cancer Institute. Office of Government and Congressional Relations. The National Cancer Act of 1971
    • (1971)
  • 3
    • 67749090506 scopus 로고    scopus 로고
    • Available at
    • Available at: http://www.cancer.org/downloads/ STT/CAFF2007PWSecured.pdf
  • 4
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature 2000; 406:747-752
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 5
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001; 98:10869-10874
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 6
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene-expression data sets
    • Sorlie T, Tibshirani R, Parker J, et al: Repeated observation of breast tumor subtypes in independent gene-expression data sets. Proc Natl Acad Sci U S A 2003; 100: 8418-8423
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 7
    • 0042838307 scopus 로고    scopus 로고
    • Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    • Sotiriou C, Neo SY, McShane LM, et al: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A 2003; 100:10393-10398
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10393-10398
    • Sotiriou, C.1    Neo, S.Y.2    McShane, L.M.3
  • 8
    • 33646874546 scopus 로고    scopus 로고
    • Hu Z, Fan C, Oh DS, et al: The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 2006; 7:96
    • Hu Z, Fan C, Oh DS, et al: The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 2006; 7:96
  • 9
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris L, Fritsche H, Mennel R, et al: American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol 2007; 25:5287-5312
    • (2007) J Clin Oncol , vol.25 , pp. 5287-5312
    • Harris, L.1    Fritsche, H.2    Mennel, R.3
  • 10
    • 34547852275 scopus 로고    scopus 로고
    • Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer
    • Goldhirsch A, Wood WC, Gelber RD, et al: Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer. Ann Oncol 2007; 18:1133-1144
    • (2007) Ann Oncol , vol.18 , pp. 1133-1144
    • Goldhirsch, A.1    Wood, W.C.2    Gelber, R.D.3
  • 11
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004; 351:2817-2826
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 12
    • 67749136841 scopus 로고    scopus 로고
    • Available at
    • Available at: http://www.clinicaltrials.gov. ClinicalTrials.gov Identifier: NCT00310180
  • 13
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van 't Veer LJ, Dai H, van de Vijver MJ, et al: Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415: 530-536
    • (2002) Nature , vol.415 , pp. 530-536
    • van 't Veer, L.J.1    Dai, H.2    van de Vijver, M.J.3
  • 14
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van 't Veer LJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347:1999-2009
    • (2002) N Engl J Med , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van 't Veer, L.J.3
  • 15
    • 33748693297 scopus 로고    scopus 로고
    • On behalf of the TRANSBIG Consortium. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse M, Loi S, van 't Veer LJ, et al: On behalf of the TRANSBIG Consortium. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst 2006; 98: 1183-1192
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    van 't Veer, L.J.3
  • 16
    • 34250652449 scopus 로고    scopus 로고
    • On behalf of the TRANSBIG Consortium. Strong time-dependency of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multi-centre independent validation series
    • Desmedt C, Piette F, Loi S, et al: On behalf of the TRANSBIG Consortium. Strong time-dependency of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multi-centre independent validation series. Clin Cancer Res 2007; 13: 3207-3214
    • (2007) Clin Cancer Res , vol.13 , pp. 3207-3214
    • Desmedt, C.1    Piette, F.2    Loi, S.3
  • 17
    • 34249311296 scopus 로고    scopus 로고
    • Individualization of therapy using Mamma-Print™: From development to the MINDACT trial
    • Mook S, van 't Veer LJ, Rutgers E, et al: Individualization of therapy using Mamma-Print™: From development to the MINDACT trial. Cancer Genomics Proteomics 2007; 4:147-156
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 147-156
    • Mook, S.1    van 't Veer, L.J.2    Rutgers, E.3
  • 18
    • 39149123547 scopus 로고    scopus 로고
    • Clinical application of the 70-gene profile (MammaPrint™): The MINDACT trial
    • Cardoso F, van 't Veer LJ, Rutgers E, et al: Clinical application of the 70-gene profile (MammaPrint™): The MINDACT trial. J Clin Oncol 2008; 10:729-735
    • (2008) J Clin Oncol , vol.10 , pp. 729-735
    • Cardoso, F.1    van 't Veer, L.J.2    Rutgers, E.3
  • 19
    • 13844310310 scopus 로고    scopus 로고
    • Gene-expression profiles to predict distant metastasis of lymph node-negative primary breast cancer
    • Wang Y, Klijn JG, Zhang Y, et al: Gene-expression profiles to predict distant metastasis of lymph node-negative primary breast cancer. Lancet 2005; 365:671-679
    • (2005) Lancet , vol.365 , pp. 671-679
    • Wang, Y.1    Klijn, J.G.2    Zhang, Y.3
  • 20
    • 33645825388 scopus 로고    scopus 로고
    • Multi-center validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer
    • Foekens JA, Atkins D, Zhang Y, et al: Multi-center validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. J Clin Oncol 2006; 24:1665-1671
    • (2006) J Clin Oncol , vol.24 , pp. 1665-1671
    • Foekens, J.A.1    Atkins, D.2    Zhang, Y.3
  • 21
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
    • Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 2006; 98:262-272
    • (2006) J Natl Cancer Inst , vol.98 , pp. 262-272
    • Sotiriou, C.1    Wirapati, P.2    Loi, S.3
  • 22
    • 34250887474 scopus 로고    scopus 로고
    • Taking gene-expression profiling to the clinic: When will molecular signatures become relevant to patient care?
    • Sotiriou C, Piccart MJ: Taking gene-expression profiling to the clinic: When will molecular signatures become relevant to patient care? Nat Rev Cancer 2007; 7:545-553
    • (2007) Nat Rev Cancer , vol.7 , pp. 545-553
    • Sotiriou, C.1    Piccart, M.J.2
  • 23
    • 44949179387 scopus 로고    scopus 로고
    • Understanding the molecular basis of histological grade
    • Ignatiadis M, Sotiriou C: Understanding the molecular basis of histological grade. Pathobiology 2008; 75:104-111
    • (2008) Pathobiology , vol.75 , pp. 104-111
    • Ignatiadis, M.1    Sotiriou, C.2
  • 24
    • 33750601244 scopus 로고    scopus 로고
    • On behalf of the TRANSBIG consortium. Prospective evaluation of a gene signature as a new prognostic tool in early stage breast cancer: Background and challenges in the design of MINDACT (Microarray In Node negative Disease May Avoid Chemotherapy Trial)
    • Bogaerts J, Cardoso F, Buyse M, et al: On behalf of the TRANSBIG consortium. Prospective evaluation of a gene signature as a new prognostic tool in early stage breast cancer: Background and challenges in the design of MINDACT (Microarray In Node negative Disease May Avoid Chemotherapy Trial). Nat Clin Prac Oncol 2006; 3:540-551
    • (2006) Nat Clin Prac Oncol , vol.3 , pp. 540-551
    • Bogaerts, J.1    Cardoso, F.2    Buyse, M.3
  • 25
    • 67749130331 scopus 로고    scopus 로고
    • Available at: http://www.adjuvantonline.com/ index.jsp
    • Available at: http://www.adjuvantonline.com/ index.jsp
  • 26
    • 26844559765 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of breast cancer
    • Hortobagyi G: Trastuzumab in the treatment of breast cancer. N Engl J Med 2006; 353: 1734-1736
    • (2006) N Engl J Med , vol.353 , pp. 1734-1736
    • Hortobagyi, G.1
  • 27
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235:177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 28
    • 26244462371 scopus 로고    scopus 로고
    • Breast cancer metastasis to the central nervous system
    • Weil RJ, Palmieri DC, Bronder JL, et al: Breast cancer metastasis to the central nervous system. Am J Pathol 2005; 167:913-920
    • (2005) Am J Pathol , vol.167 , pp. 913-920
    • Weil, R.J.1    Palmieri, D.C.2    Bronder, J.L.3
  • 29
    • 67749119366 scopus 로고    scopus 로고
    • Slamon D, Eiermann W, Robert N, et al: BCIRG 2006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2neu positive early breast cancer patients. Breast Cancer Res Treat 2006; 100: abstract 52
    • Slamon D, Eiermann W, Robert N, et al: BCIRG 2006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2neu positive early breast cancer patients. Breast Cancer Res Treat 2006; 100: abstract 52
  • 30
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353:1673-1684
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 31
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al: Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006; 354:809-820
    • (2006) N Engl J Med , vol.354 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.L.2    Bono, P.3
  • 32
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al: Trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer. N Engl J Med 2005; 353:1659-1672
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 33
    • 33845914783 scopus 로고    scopus 로고
    • 2 year follow-up of trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer: A randomized controlled trial
    • Smith I, Procter M, Gelber RD, et al: 2 year follow-up of trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer: A randomized controlled trial. Lancet 2007; 369:29-36
    • (2007) Lancet , vol.369 , pp. 29-36
    • Smith, I.1    Procter, M.2    Gelber, R.D.3
  • 34
    • 67749151027 scopus 로고    scopus 로고
    • at
    • Avialable at: http://www.frontier-science.co. uk/index.php
    • Avialable
  • 35
    • 34548531901 scopus 로고    scopus 로고
    • Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial
    • Suter TM, Proctere M, van Veldhuisen DJ, et al: Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol 2007; 25:3859-3865
    • (2007) J Clin Oncol , vol.25 , pp. 3859-3865
    • Suter, T.M.1    Proctere, M.2    van Veldhuisen, D.J.3
  • 36
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355:2733-2743
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 37
    • 34250655315 scopus 로고    scopus 로고
    • Cardiac safety experience in 3127 patients treated with lapatinib
    • abstract 1420
    • Perez EA, Byrne JA, Isaac W, et al: Cardiac safety experience in 3127 patients treated with lapatinib. Ann Oncol 2006; 17(Suppl 9):ix70; abstract 1420.
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 9
    • Perez, E.A.1    Byrne, J.A.2    Isaac, W.3
  • 38
    • 33751205030 scopus 로고    scopus 로고
    • Lapatinib: Current status and future directions in breast cancer
    • Moy B, Goss PE: Lapatinib: Current status and future directions in breast cancer: Oncologist 2006; 11:1047-1057
    • (2006) Oncologist , vol.11 , pp. 1047-1057
    • Moy, B.1    Goss, P.E.2
  • 39
    • 67749087760 scopus 로고    scopus 로고
    • Lin NU, Dieras V, Paul D, et al; EGF105084 Study Group: EGF105084, a Phase II Study of Lapatinib for Brain Metastases in Patients (pts) with HER2+ Breast Cancer Following Trastuzumab (h) Based Systemic Therapy and Cranial Radiotherapy (RT). J Clin Oncol 2007; ASCO Annual Meeting Proceedings; 25, 18S (June 20 Supplement): 1012
    • Lin NU, Dieras V, Paul D, et al; EGF105084 Study Group: EGF105084, a Phase II Study of Lapatinib for Brain Metastases in Patients (pts) with HER2+ Breast Cancer Following Trastuzumab (h) Based Systemic Therapy and Cranial Radiotherapy (RT). J Clin Oncol 2007; ASCO Annual Meeting Proceedings; 25, 18S (June 20 Supplement): 1012
  • 40
    • 42149174337 scopus 로고    scopus 로고
    • La nouvelle generation des etudes cliniques sur le cancer du sein: La bonne drogue et la bonne cible.
    • de Azambuja E, Cardoso F, Meirsman L, et al: La nouvelle generation des etudes cliniques sur le cancer du sein: La bonne drogue et la bonne cible. Bull Cancer 2008; 95: 352-357
    • (2008) Bull Cancer , vol.95 , pp. 352-357
    • de Azambuja, E.1    Cardoso, F.2    Meirsman, L.3
  • 42
    • 67749087761 scopus 로고    scopus 로고
    • BIG-North America initiative
    • Enos R: BIG-North America initiative. Breast International Group Newsletter 2006, Volume 8, Issue 2, pages 4-5
    • (2006) Breast International Group Newsletter , vol.8 , Issue.2 , pp. 4-5
    • Enos, R.1
  • 43
    • 57149104138 scopus 로고    scopus 로고
    • Recommendations for collection and handling of specimens from group breast cancer clinical trials, from onsite collection through shipping to the central bank
    • Oct 27 [Epub ahead of print, 10.1200/JCO.2007.15.1712
    • Leyland-Jones B, Ambrosone CB, Bartlett JMS, et al: Recommendations for collection and handling of specimens from group breast cancer clinical trials, from onsite collection through shipping to the central bank. J Clin Oncol 2008; Oct 27 [Epub ahead of print], 10.1200/JCO.2007.15.1712
    • (2008) J Clin Oncol
    • Leyland-Jones, B.1    Ambrosone, C.B.2    Bartlett, J.M.S.3
  • 44
    • 67749099051 scopus 로고    scopus 로고
    • MINDACT and TAILORx Collaboration: Validating promising tools for early breast cancer
    • Cardoso F, Ellis M: MINDACT and TAILORx Collaboration: Validating promising tools for early breast cancer. Breast International Group Newsletter 2007, Volume 9, Issue 3, page 32
    • (2007) Breast International Group Newsletter , vol.9 , Issue.3 , pp. 32
    • Cardoso, F.1    Ellis, M.2
  • 45
    • 33745406564 scopus 로고    scopus 로고
    • Slow start to phase 0 as researchers debate value
    • Twombly R: Slow start to phase 0 as researchers debate value. J Natl Cancer Inst 2006; 98:804-806
    • (2006) J Natl Cancer Inst , vol.98 , pp. 804-806
    • Twombly, R.1
  • 46
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004; 3:711-715
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 47
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92:205-216
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 48
    • 33749029255 scopus 로고    scopus 로고
    • Sometimes size doesn't matter: Reevaluating RECIST and tumor response rate endpoints
    • Tuma RS: Sometimes size doesn't matter: reevaluating RECIST and tumor response rate endpoints. J Natl Cancer Inst 2006; 98: 1272-1274
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1272-1274
    • Tuma, R.S.1
  • 49
    • 36849047716 scopus 로고    scopus 로고
    • Different prognostic value of Cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor and HER2 status in early breast cancer
    • Ignatiadis M, Xenidis N, Perraki M, et al: Different prognostic value of Cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor and HER2 status in early breast cancer. J Clin Oncol 2007; 25:5194-5202
    • (2007) J Clin Oncol , vol.25 , pp. 5194-5202
    • Ignatiadis, M.1    Xenidis, N.2    Perraki, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.