High absolute bioavailability of methylene blue given as an aqueous oral formulation

European Journal of Clinical Pharmacology

Volumn 65, Issue 2, 2009, Pages 179-189

  Walter Sack, Ingeborg ^a   Rengelshausen, Jens ^a,c   Oberwittler, Heike ^a,c   Burhenne, Juergen ^a   Mueller, Olaf ^b   Meissner, Peter ^b,d   Mikus, Gerd ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c AIC Kijabe Hospital of Eldoret University ^*  (France)

^d Department of Paediatrics Tropical Hygiene and Public Health   (Kenya)

Author keywords

Bioavailability; Chloroquine; Kinetics; Methylene blue

Indexed keywords

CHLOROQUINE; METHYLENBLAU VITIS; METHYLENE BLUE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; DYSURIA; FEMALE; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; VENOUS BLOOD; VOMITING;

ADMINISTRATION, ORAL; ADULT; ANTIMALARIALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHLOROQUINE; CROSS-OVER STUDIES; DRUG THERAPY, COMBINATION; FEMALE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; METHYLENE BLUE; PLASMA; TABLETS; TIME FACTORS; WATER; YOUNG ADULT;

EID: 58849144632     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0563-x     Document Type: Article

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