Hot melt granulation of coarse pharmaceutical powders in a spouted bed

Powder Technology

Volumn 189, Issue 3, 2009, Pages 520-527

  Borini, G B ^a   Andrade, T C ^a   Freitas, Luis A P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dissolution tests; Factorial design; Flowability; Size distribution; Tableting

Indexed keywords

AIR FLOW RATES; AIR PRESSURES; CENTER POINTS; COARSE POWDERS; CONSOLIDATION PROPERTIES; DISSOLUTION TESTS; DRUG MODELS; FACTORIAL DESIGN; FEED RATES; FLOWABILITY; GRANULE SIZES; HAUSNER RATIOS; HOT MELTS; IN-VITRO DISSOLUTIONS; PHARMACEUTICAL POWDERS; POLY-VINYL-PYRROLIDONE; RELEASE PROFILES; SPOUTED BEDS; SPRAY CONDITIONS; SPRAY NOZZLES; TABLETING; TAPPED DENSITIES; TWO FLUIDS; VERTICAL POSITIONS;

ATMOSPHERIC PRESSURE; BINDERS; COMPRESSIVE STRENGTH; DISSOLUTION; ETHYLENE GLYCOL; GLYCOLS; NOZZLES; PESTICIDES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POWDERS; REGRESSION ANALYSIS; SIZE DISTRIBUTION; SUGARS;

GRANULATION;

LACTOSE POLYVINYLPYRROLIDONE; MACROGOL 4000; PARACETAMOL; POVIDONE DERIVATIVE; UNCLASSIFIED DRUG;

AIRFLOW; ARTICLE; ATMOSPHERIC PRESSURE; ATOM; BINDING AFFINITY; BULK DENSITY; COARSE PHARMACEUTICAL POWDER; CONTROLLED STUDY; DISSOLUTION; DRUG FORMULATION; DRUG INDUSTRY; DRUG RELEASE; ENZYME SUBSTRATE; FLOW RATE; FLUIDIZATION; FLUIDIZED BED; HEATING; HOT MELT GRANULATION; IN VITRO STUDY; KINETICS; MELTING POINT; MOLECULAR WEIGHT; NEBULIZATION; PARTICLE SIZE; POLYMERIZATION; POWDER; TABLET;

EID: 58849143799     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.08.004     Document Type: Article

References (32)

1. Mujumdar A.S. Spouted beds - a brief review. Chemical Age of India 38 11 (1987) 589-594
2. Freitas L.A.P., and Freire J.T. Analysis of fluid dynamics in a spouted bed with continuous solids feed. Drying Technology 16 9&10 (1998) 1903-1921
3. Marreto R.N., Freire J.T., and Freitas L.A.P. Development of spouted bed drying of pharmaceuticals. Drying Technology 24 (2006) 327-338
4. Freitas L.A.P., and Freire J.T. Development of a spouted bed coater for tablets. In: Olazar M. (Ed). Proceedings of the II Congres Europeen sur la Fluidisation (1997) 353-362 Bilbao, Spain
5. Choi M.M.S., and Meisen A. Sulfur coating of urea in shallow spouted beds. Chemical Engineering Science 52 7 (1997) 1073-1086
6. Kfuri C.R., and Freitas L.A.P. A comparative study of spouted and spout-fluid beds for tablets coating. Drying Technology 23 12 (2005) 2369-2388
7. Pavarini P.J., and Coury J.R. Granulation of an insoluble powder in a spouted bed. Powder Technology 53 (1987) 97-103
8. Tsukada M., Goto K., Yamamoto R.H., and Horio M. Metal powder granulation in a plasma spouted/fluidized bed. Powder Technology 82 (1995) 347-353
9. Yu C.Y., Xu Y.K., and Wang X.Z. Study of fluidized bed spray granulation. Drying Technology 17 9 (1999) 1893-1904
10. Achanta A.S., Adsumilli P.S., James K.W., and Rhodes C.T. Development of hot melt coating methods. Drug Development and Industrial Pharmacy 23 5 (1997) 441-449
11. Kidokoro M., Haramiishi Y., Sagasaki S., Shimizu T., and Yamamoto Y. Application of Fluidized Hot Melt Granulation (FHMG) for the preparation of granules for tableting: properties of granules and tablets prepared by FHMG. Drug Development and Industrial Pharmacy 28 1 (2002) 67-76
12. Walker G.M., Holland C.R., Ahmad M.M.N., and Craig D.Q.M. Influence of process parameters on fluidized hot melt granulation and tablet pressing of pharmaceutical powders. Chemical Eng. Sci. 60 (2005) 3867-3877
13. Faham A., Prinder P., Farah N., Eichler K.D., Kalantzis G., and Joachim J. Hot melt coating technology. I: Influence of Compritol 888 ATO and granule size on theophylline release. Drug Development and Industrial Pharmacy 26 2 (2000) 167-176
14. Shimpi S., Chauhan B., Mahadik K.R., and Paradkar A. Preparation and evaluation of diltiazem hydrochloride-Gelucire 43/01 floating granules prepared by melt granulation. AAPS PharmSciTech 5 3 (2004) Article 43
15. Freitas L.A.P., and Freire J.T. Heat transfer in spouted beds. Drying Technology 11 2 (1993) 303-317
16. Freitas L.A.P., and Freire J.T. Gas-to-particle heat transfer in the draft tube of a spouted bed. Drying Technology 19 6 (2001) 1065-1082
17. Freitas L.A.P., and Freire J.T. Heat transfer in a draft tube spouted bed with bottom solids feed. Powder Technology 114 1-3 (2001) 152-162
18. Weiss J.P., and Meissen A. Laboratory studies on sulphur coating of urea by spouted bed process. Canadian Journal of Chemical Engineering 61 (1983) 440-447
19. Box M., Hunter W.G., and Hunter J.S. Statistics for Experimenters (1978), John Wiley & Sons, N. York
20. Mathur K.B., and Epstein N. Spouted Beds (1974), Academic Press, NY
21. Borini G.B., and Freitas L.A.P. Study on the spray congealing of a pharmaceutical wax, IDS. Proceedings of the 15th International Drying Symposium, Budapest, Hungary, 20-23 August 2006, Volume I, pg (2006)
22. Wells J.I. Pharmaceutical Preformulation: The Physicochemical Properties of Drug Substances (1988), Ellis Horwood Ltd. Publ., West Sussex, England 227 pp.
23. United States Pharmacopeia. 23rd Ed. (1995), United States Pharmacopeial Convention, Rockville 4197-4198 suppl.8
24. Walker G.M., Andrews G., and Jones D. Effect of process parameters on the melt granulation of pharmaceutical powders. Powder Technology 165 (2006) 161-166
25. Ouchiyama N., and Tanaka T. The probability of coalescence in granulation kinetics. Industrial & Engineering Chemistry Process Design and Development 14 (1995) 286-289
26. Ennis B.J., Tardos G.I., and Pfeffer R. A microlevel-based characterization of transport phenomena. Powder Technology 65 (1991) 257-272
27. Iveson S., and Litster J. Growth regime map for liquid-bond granules. AIChE Journal 44 (1998) 1510-1518
28. Tan H.S., Goldschmidt M.J.V., Boerefijn R., Hounslow M.J., Salman A.D., and Kuipers J.A.M. Building population balance model for fluidized bed melt granulation: lessons from kinetic theory of granular flow. Powder Technology 142 (2004) 103-109
29. Filkova I., and Mujumdar A.S. Industrial spray drying systems. Chapter 9, pg. 263. In: Mujumdar A.S. (Ed). Handbook of Industrial Drying (1995), Marcel Dekker Inc., New York, NY
30. Abberger T., Seo A., and Schaefer T. The effect of droplet size and powder particle size on the mechanisms of nucleation and growth in fluid bed melt agglomeration. International Journal of Pharmaceutics 249 1-2 (2002) 185-197
31. Rowe R.C., Sheskey P.J., and Weller P.J. Pharmaceutical Excipients, American Pharmaceutical Association, CD-ROM, Windows v. 2.0 (2001)
32. Jozwiakowski M.J., Jones D.M., and Franz R.M. Characterization of a hot melt fluid bed coating process for fine granules. Pharmaceutical Research 7 11 (1990) 1119-1126