A study of the teratogenic and fetotoxic effects of large doses of barbital, hexobarbital and butobarbital used for suicide attempts by pregnant women

Toxicology and Industrial Health

Volumn 24, Issue 2, 2008, Pages 109-119

  Timmermann, G ^a   Czeizel, Ae ^b   Banhidy F ^a   Acs N ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b FOUNDATION FOR THE COMMUNITY CONTROL OF HEREDITARY DISEASES   (Hungary)

Author keywords

barbital; behavioral development; birth weight; butobarbital; cognitive status; congenital abnormalities; hexobarbital; pregnancy age; suicide attempt during pregnancy

Indexed keywords

BARBITURIC ACID DERIVATIVE; HYPNOTIC SEDATIVE AGENT; ALKALOID DERIVATIVE; AMINOPHENAZONE; BARBAMID; BARBITAL; BELLOID; BUTETHAL; CHLORDIAZEPOXIDE; HEXOBARBITAL; HYOSCYAMINE; NITRAZEPAM; SECALIS CORNUTI ALKALOIDA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; FETUS DEVELOPMENT; HUMAN; HUNGARY; INFANT; MALE; NEWBORN; PREGNANCY; PREGNANT WOMAN; PRENATAL EXPOSURE; STATISTICS; SUICIDE ATTEMPT; BEHAVIOR; BIRTH WEIGHT; COGNITION; CONTROLLED STUDY; DELIVERY; DRUG OVERDOSE; FETOTOXICITY; FETUS GROWTH; GESTATIONAL AGE; INGUINAL HERNIA; MAJOR CLINICAL STUDY; NEUROTOXICITY; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRENATAL GROWTH; PREVALENCE; SELF POISONING; SIBLING; TERATOGENESIS; TIME PERCEPTION; TOXICOLOGY;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; BARBITURATES; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEVELOPMENT; HUMANS; HUNGARY; HYPNOTICS AND SEDATIVES; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; PREGNANT WOMEN; PRENATAL EXPOSURE DELAYED EFFECTS; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 58849136815     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708089004     Document Type: Article

References (21)

1. Briggs GG, Freeman RK, Yaffe SJ (2005) Drugs in Pregnancy and Lactation, seventh ed. Philadelphia: Lipincott Williams and Wilkins.
2. Czeizel AE (1986) Self-poisoning as a model for the study of mutagenicity and teratogenicity of chemicals on human beings. In: C Ramel, B Lambert, J Magnusson. (eds), Genetic Toxicology of Environmental Chemicals. Part B: Genetic Effects and Applied Mutagenesis. New York: Alan R. Liss, pp. 237–244.
3. Czeizel AE (1994) Budapest registry of self-poisoned patients. Mutat Res 312: 157–163.
4. Czeizel AE, Bod M, Halász P (1992) Evaluation of anticonvulsant drugs during pregnancy in a population-based Hungarian study. Eur J Epidemiol 8: 122–127.
5. Czeizel AE, Gidai J, Petik D, Timmermann G, Puhó EH (2008) Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Toxicol Ind Health 24: 11–28.
6. Czeizel AE, Lendvay A (1989) Attempted suicide and pregnancy. Am J Obstet Gynecol 161: 497.
7. Czeizel AE, Petik D, Puhó E (2004) Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Cent Eur J Publ Health 12: 179–183.
8. Czeizel AE, Rockenbauer M, Siffel CS, Varga E (2001) Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980–1996. Teratology 63: 176–185.
9. Czeizel AE, Szentesi I, Szekeres I, Glauber A, Bucski P, Molnár C (1984) Pregnancy outcome and health conditions of offspring of self-poisoned pregnant women. Acta Paediatr Hung 25: 209–236.
10. Czeizel AE, Szentesi I, Szekeres I, Molnár G, Glauber A, Bucski P (1988) A study of adverse effects on the progeny after intoxication during pregnancy. Arch Toxicol 62: 1–7.
11. Czeizel AE, Tomcsik J, Tímár L (1997) Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstet Gynecol 90: 195–201.
12. Dobson Sz (2002) Phenobarbital, phenytoin. In: Dobson, Sz, (ed), Milestone in the History of Pharmaceutical Therapy. Budapest: (Hungarian) Dictum Publ., pp. 13–15.
13. Draffan GH, Dollery CT, Davies DS (1976) Maternal and neonatal elimination of amobarbital after treatment of the mother with barbiturates during late pregnancy. Clin Pharmacol Ther 19: 271–275.
14. FDA : Food and Drug Administration (1980) Fetal Risk Summary. Federal Register 44: 37434–37467.
15. Friedman JM, Polifka JE (1996) The Effects of Drugs on the Fetus and Nursing Infants. Baltimore: Johns Hopkins University Press.
16. Janz D, Fuchs V (1964) Are anti-epileptic drugs harmful when given during pregnancy? German Med Monogr 9: 20–23.
17. Kraver B, Draffan GH, Williams FM (1973) Elimination kinetics of amobarbital in mothers and newborn infants. Clin Pharmacol Ther 14: 442–447.
18. Lendvay A, Czeizel AE (1992) A behavioural teratologic study on offspring of self-poisoned pregnant women. Acta Paediatr Hung 32: 347–369.
19. Petik D, Timmermann G, Czeizel AE, Ács N, Bánhidy F (2008) A study of teratogenic and fetotoxic effect of large doses of amobarbital used for a suicide attempt by 14 pregnant women. Toxic Ind Health 79–85.
20. Shepard TH, Lemire RJ (2004) Catalog of Teratogenic Agents, eleventh ed. Baltimore: Johns Hopkins University Press.
21. Szegal B (1980) Diagnostic of psychomotor development. Hung Psychol 37: 148–188.