Healing of ulcers due to cryofibrinogenemia with colchicine and high-dose pentoxifylline

American Journal of Clinical Dermatology

Volumn 10, Issue 1, 2009, Pages 39-42

  Chartier, Molly ^a   Falanga, Vincent ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Colchicine, therapeutic use; Pentoxifylline, therapeutic use; Ulcer

Indexed keywords

COLCHICINE; PENTOXIFYLLINE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ARTICLE; BIOPSY; BLOOD PRESSURE REGULATION; CASE REPORT; CRYOFIBRINOGENEMIA; DRUG MEGADOSE; FIBRINOGEN BLOOD LEVEL; FOOT ULCER; HUMAN; HUMAN TISSUE; HYPERTENSION; LEG ULCER; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; SMOKING; THROMBUS; ULCER HEALING; VASCULITIS; WOUND CARE;

COLCHICINE; CRYOGLOBULINEMIA; CRYOGLOBULINS; DRUG THERAPY, COMBINATION; FIBRINOGENS, ABNORMAL; HUMANS; MALE; MIDDLE AGED; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; SKIN ULCER; TUBULIN MODULATORS;

EID: 58849136629     PISSN: 11750561     EISSN: None     Source Type: Journal    
DOI: 10.2165/0128071-200910010-00007     Document Type: Article

References (23)

1. Falanga V, Fujitani RM, Diaz C, et al. Systemic treatment of venous leg ulcers with high doses of pentoxyfylline: efficacy in a randomized, placebo-controlled trial. Wound Rep Reg 1999; 7: 208-13
2. Falanga V, Kerser RS, Eaglestein WH, et al. Stanozolol in treatment of leg ulcers due to cryofibrinogenaemia. Lancet 1991 Aug; 338 (8763): 347-8
3. McKee PA, Kalbfleisch JM, Bird RM. Incidence and significance of cryofibrinogenemia. J Lab Clin Med 1963; 61: 203-10
4. Klein AD, Kerdel FA. Purpura and recurrent ulcers on the lower extremities: essential cryofibrinogenemia. Arch Dermatol 1991 Jan; 127 (1): 115-8
5. Helfman T, Falanga V. Stanozolol as a novel therapeutic agent in dermatology. J Am Acad Dermatol 1995 Aug; 33 (2 Pt 1): 254-8
6. Kirsner RS, Eaglstein WH, Katz MH, et al. Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia. J Am Acad Dermatol 1993 Jan; 28 (1): 71-4
7. Beightler E, Diven DG, Sanchez RL, et al. Thrombotic vasculopathy associated with cryofibrinogenemia. J Am Acad Dermatol 1992 Feb; 24 (2 Pt 2): 342-5
8. Copeman PWM. Cryofibrinogenaemia and skin ulcers: treatment with plasmapheresis [abstract]. Br J Dermatol 1979; 101 (17 Suppl.): 57
9. Rachmilewitz EA, Sacks MI, Zlotnick A. Essential cryofibrinogenemia: clinical, pathological and immunological studies. Isr J Med Sci 1970; 6: 32-43
10. Ehrlich HP, Grislis G, Hunt TK. Evidence for the involvement of microtubules in wound contraction. Am J Surg 1977 Jun; 133 (6): 706-9
11. Smith Jr JG. Vasculitis. J Dermatol 1995 Nov; 22 (11): 812-22
12. Eisen D, Lynch DP. Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis 2001 Sep; 68 (3): 201-6
13. Kaklamani VG, Kaklamanis PG. Treatment of Behçet's disease: an update. Semin Arthritis Rheum 2001 Apr; 30 (5): 299-312
14. MayoClinic. Drugs and supplements [online]. Available from URL: http://www.mayoclinic.com/health/drug-information/DR202160 [Accessed 2007 Mar 22]
15. Samlaska CP, Winfield EA. Pentoxifylline. J Am Acad Dermatol 1994 Apr; 30 (4): 603-21
16. Chang CC, Chang TC, Kao SCS, et al. Pentoxyfylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema. Acta Endocrinologica 1993; 129: 322-7
17. Colgan MP, Dormandy JA, Jones PW, et al. Oxpentifylline treatment of venous ulcers of the leg. BMJ 1990 Apr; 300 (6730): 972-5
18. Frost ML, Treadwell P. Treatment of sickle cell leg ulcers with pentoxifylline. Int J Dermatol 1990 Jun; 29 (5): 375-6
19. Brenman SA. Pentoxifylline as adjunctive therapy in leg ulcer management. J Am Osteopath Assoc 1991 Jul; 91 (7): 677-86
20. Ruddock MW, Hirst DG. Pentoxifylline inhibits agonist-induced vasoconstriction in vascular smooth muscle and spontaneous peristalsis in isolated ileum. Oncol Res 2005; 15 (2): 81-6
21. Peterson TC, Isbrucker RA, Hooper ML. In vitro effect of platelet-derived growth factor on fibroproliferation and effect of cytokine antagonists. Immunopharmacology 1994 Nov-Dec; 28 (3): 259-70
22. RxList. Colchicine: side effects and drug interactions [online]. Available from URL: http://www.rxlist.com/cgi/generic2/colch-ad.htm [Accessed 2007 Mar 22]
23. Physician's desk reference. 59th ed. Montvale (NJ): Thompson PDR, 2005: 754-5