Muscarinic modulation of recruitment threshold and firing rate in rat oculomotor nucleus motoneurons

Journal of Neurophysiology

Volumn 101, Issue 1, 2009, Pages 100-111

  Nieto Gonzalez, Jose Luis ^a   Carrascal, Livia ^a   Nunez Abades, Pedro ^a   Torres, Blas ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR;

AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE POTENTIAL; MOTONEURON; NONHUMAN; OCULOMOTOR NERVE; PRIORITY JOURNAL; RAT;

ANESTHETICS, LOCAL; ANIMALS; BLOTTING, WESTERN; DATA INTERPRETATION, STATISTICAL; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIALS; MOTOR NEURONS; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; OCULOMOTOR MUSCLES; OCULOMOTOR NERVE; PARASYMPATHETIC NERVOUS SYSTEM; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; RECRUITMENT, NEUROPHYSIOLOGICAL; SYNAPSES; TETRODOTOXIN;

EID: 58849115094     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.90239.2008     Document Type: Article

References (51)

1. Alaburda A, Perrier JF, Hounsgaard J. An M-like outward current regulates the excitability of spinal motoneurones in the adult turtle. J Physiol 540: 875-881, 2002.
2. Binder MD, Heckman CJ, Powers RK. How different afferent inputs control motoneuron discharge and the output of the motoneuron pool. Curr Opin Neurobiol 3: 1028-1034, 1993
3. Brown BS, Yu SP. Modulation and genetic identification of the M channel. Prog Biophys Mol Biol 73: 135-166, 2000
4. Cameron WE, Nunez-Abades PA, Kerman IA, Hodgson TM. Role of potassium conductances in determining input resistance of developing brain stem motoneurons. J Neurophysiol 84: 2330-2339, 2000
5. + channels: an unexpected form of cellular plasticity. Nat Rev Neurosci 2: 397-407, 2001.
6. Carpenter MB, Periera AB, Guha N. Immunocytochemistry of oculomotor afferents in the squirrel monkey (Saimiri sciureus). J Hirnforsch 33: 151-167, 1992
7. Carrascal L, Nieto-Gonzalez JL, Cameron WE, Torres B, Nunez-Abades PA. Changes during the postnatal development in physiological and anatomical characteristics of rat motoneurons studied in vitro. Brain Res Rev 49: 377-387, 2005.
8. Carrascal L, Nieto-Gonzalez JL, Nunez-Abades P, Torres B. Temporal sequence of changes in electrophysiological properties of oculomotor motoneurons during postnatal development. Neuroscience 140: 1223-1237, 2006
9. Chamberlin NL, Bocchiaro CM, Greene RW, Feldman JL. Nicotinic excitation of rat hypoglossal motoneurons. Neuroscience 115: 861-870, 2002
10. Chevallier S, Nagy F, Cabelguen JM. Cholinergic control of excitability of spinal motoneurones in the salamander. J Physiol 570: 525-540, 2006
11. Dean P. Simulated recruitment of medial rectus motoneurons by abducens internuclear neurons: synaptic specificity vs. intrinsic motoneuron properties. J Neurophysiol 78: 1531-1549, 1997
12. de la Cruz RR, Escudero M, Delgado-García JM. Behaviour of medial rectus motoneurons in the alert cat. Eur J Neurosci 1: 288-295, 1989
13. Delgado-García JM, del Pozo F, Baker R. Behavior of neurons in the abducens nucleus of the alert cat. I. Motoneurons. Neuroscience 17: 929-952, 1986
14. Delgado-García JM, Yajeya J, Navarro-López Jde D. A cholinergic mechanism underlies persistent neural activity necessary for eye fixation. Prog Brain Res 154: 211-224, 2006.
15. Disney AA, Domakonda KV, Aoki C. Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey. J Comp Neurol 499: 49-63, 2006
16. Eglen RM. Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Auton Autacoid Pharmacol 26: 219-233, 2006
17. Fernández de Sevilla D, Rodrigo-Angulo M, Nuñez A, Buño W. Cholinergic modulation of synaptic transmission and postsynaptic excitability in the rat gracilis dorsal column nucleus. J Neurosci 26: 4015-4025, 2006.
18. Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, Wess J. Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron 33: 615-624, 2002
19. + currents increases the excitability of rat neocortical pyramidal neurones. J Physiol 528: 291-304, 2000.
20. Fuchs AF, Scudder CA, Kaneko CR. Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus. J Neurophysiol 60: 1874-1895, 1988
21. Hazel TR, Sklavos SG, Dean P. Estimation of premotor synaptic drives to simulated abducens motoneurons for control of eye position. Exp Brain Res 146: 184-196, 2002
22. Hellström J, Oliveira AL, Meister B, Cullheim S. Large cholinergic nerve terminals on subsets of motoneurons and their relation to muscarinic receptor type 2. J Comp Neurol 460: 476-486, 2003.
23. Honda E, Ono K, Toyono T, Kawano H, Masuko S, Inenaga K. Activation of muscarinic receptors in rat subfornical organ neurones. J Neuroendocrinol 15: 770-777, 2003
24. Ichikawa T, Shimizu T. Organization of choline acetyltransferase-containing structures in the cranial nerve motor nuclei and spinal cord of the monkey. Brain Res 1; 779: 96-103, 1998
25. Johnson SM, Bywood PT. Degeneration of the dendritic arbor as an index of neurotoxicity in identified catecholamine neurons in rat brain slices. Exp Neurol 151: 221-228, 1998
26. Jones MS, Ariel M. Morphology, intrinsic membrane properties, and rotation-evoked responses of trochlear motoneurons in the turtle. J Neurophysiol 99: 1187-1200, 2008.
27. Klink R, Alonso A. Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons. J Neurophysiol 77: 1813-1828, 1997a
28. Klink R, Alonso A. Ionic mechanisms of muscarinic depolarization in entorhinal cortex layer II neurons. J Neurophysiol 77: 1829-1843, 1997b
29. Krnjevic K. Central cholinergic mechanisms and function. Prog Brain Res 98: 285-292, 1993
30. Lape R, Nistri A. Current and voltage clamp studies of the spike medium afterhyperpolarization of hypoglossal motoneurons in a rat brain stem slice preparation. J Neurophysiol 83: 2987-2995, 2000
31. Magarinos-Ascone C, Nuñez A, Delgado-García JM. Different discharge properties of rat facial nucleus motoneurons. Neuroscience 94: 879-886, 1999
32. McQuiston AR, Madison DV. Muscarinic receptor activity has multiple effects on the resting membrane potentials of CA1 hippocampal interneurons. J Neurosci 19: 5693-5702, 1999.
33. Mendell LM. The size principle: a rule describing the recruitment of motoneurons. J Neurophysiol 93: 3024-3026, 2005
34. Miles GB, Hartley R, Todd AJ, Brownstone RM. Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion. Proc Natl Acad Sci USA 104: 2448-2453, 2007
35. Navarro-López Jde D, Alvarado JC, Márquez-Ruiz J, Escudero M, Delgado-García JM, Yajeya J. A cholinergic synaptically triggered event participates in the generation of persistent activity necessary for eye fixation. J Neurosci 24: 5109-5118, 2004
36. Nguyen LT, Spencer RF. Abducens internuclear and ascending tract of Deiters inputs to medial rectus motoneurons in the cat oculomotor nucleus: neurotransmitters. J Comp Neurol 411: 73-86, 1999
37. Nieto-Gonzalez JL, Carrascal L, Nunez-Abades PA, Torres B. Phasic and tonic firing properties in rat oculomotor nucleus motoneurons, studied in vitro. Eur J Neurosci 25: 2682-2696, 2007
38. Nuñez A, De la Roza C, Rodrigo-Angulo ML, Buño W, Reinoso-Suarez F. Electrophysiological properties and cholinergic responses of rat ventral oral pontine reticular neurons in vitro. Brain Res 754: 1-11, 1997
39. Nunez-Abades PA, Pattillo JM, Hodgson TM, Cameron WE. Role of synaptic inputs in determining input resistance of developing brain stem motoneurons. J Neurophysiol 84: 2317-2329, 2000
40. Nunez-Abades PA, Spielmann JM, Barrionuevo G, Cameron WE. In vitro electrophysiology of developing genioglossal motoneurons in the rat. J Neurophysiol 70: 1401-1411, 1993
41. Pastor AM, Gonzalez-Forero D. Recruitment order of cat abducens motoneurons and internuclear neurons. J Neurophysiol 90: 2240-2252, 2003
42. Pastor AM, Torres B, Delgado-García JM, Baker R. Discharge characteristics of medial rectus and abducens motoneurons in the goldfish. J Neurophysiol 66: 2125-2140, 1991
43. Sawczuk A, Powers RK, Binder MD. Spike frequency adaptation studied in hypoglossal motoneurons of the rat. J Neurophysiol 73: 1799-1810, 1995
44. Spencer RF, Wang SF. Immunohistochemical localization of neurotransmitters utilized by neurons in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) that project to the oculomotor and trochlear nuclei in the cat. J Comp Neurol 366: 134-148, 1996
45. Stahl JS, Simpson JI. Dynamics of abducens nucleus neurons in the awake rabbit. J Neurophysiol 73: 1383-1395, 1995
46. Sun Y, Waller HJ, Godfrey DA, Rubin AM. Spontaneous activity in rat vestibular nuclei in brain slices and effects of acetylcholine agonists and antagonists. Brain Res 934: 58-68, 2002
47. Sylvestre PA, Cullen KE. Quantitative analysis of abducens neuron discharge dynamics during saccadic and slow eye movements. J Neurophysiol 82: 2612-2632, 1999
48. Thompson SM, Masukawa LM, Prince DA. Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro. J Neurosci 5: 817-824, 1985
49. Yajeya J, de la Fuente JA, Bajo VM, Riolobos AS, Heredia M, Criado JM. Muscarinic activation of a non-selective cationic conductance in pyramidal neurons in rat basolateral amygdala. Neuroscience 88: 159-167, 1999
50. Yajeya J, de la Fuente JA, Merchan MA, Riolobos AS, Heredia M, Criado JM. Cholinergic responses of morphologically and electrophysiologically characterized neurons of the basolateral complex in rat amygdala slices. Neuroscience 78: 731-743, 1997
51. Zaninetti M, Tribollet E, Bertrand D, Raggenbass M. Presence of functional neuronal nicotinic acetylcholine receptors in brainstem motoneurons of the rat. Eur J Neurosci 11: 2737-2748, 1999