Are laboratory tests useful for monitoring the activity of lupus nephritis? A 6-year prospective study in a cohort of 228 patients with lupus nephritis

Annals of the Rheumatic Diseases

Volumn 68, Issue 2, 2009, Pages 234-237

  Moroni, G ^a   Radice, A ^d   Giammarresi, G ^b   Quaglini, S ^c   Gallelli, B ^a   Leoni, A ^a   Vecchi, M L ^b   Messa, P ^a   Sinico, R A ^d  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d SAN CARLO BORROMEO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPID ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; HUMAN; IMMUNOLOGICAL PROCEDURES; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEINURIA;

ADULT; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; BIOLOGICAL MARKERS; COMPLEMENT C1Q; COMPLEMENT C3; COMPLEMENT C4; DNA; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LUPUS NEPHRITIS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 58849111801     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.094508     Document Type: Article

References (15)

1. Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, de Ramon Garrido E, Danieli MG, et a/. Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long-term follow-up of patients in the Euro-Lupus Nephritis Trial. Arthritis Rheum 2004;50:3934-0.
2. Moroni G, Quaglini S, Maccario M, Banfi G., Ponticelli C. Nephritic flares are predictors of bad long-term outcome in lupus nephritis. Kidney Int 1996:50:2047-53.
3. Ravirarjan CT, Rowse L, MacGowan JR, Isemberg DA. An analysis of clinical disease activity and nephritis associated serum autoantibodies profiles in patients with systemic lupus erythematosus: a cross sectional study. Rheumatology 2001:40:1405-12.
4. Ho A, Magder LS, Barr SG, Petrí M. Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2342-9.
5. Esdaile JM, Abrahamowicz M, Joseph L, MacKenzie T, Li Y, Danoff D. Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum 1996;39:370-8.
6. Siegert CE, Daha MR, Tseng CM, Coremans IE, van Es LA, Breedveld FC. Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus. Ann Rheum Dis 1993;52:851-6.
7. Trendelenburg M, Marfurt J, Gerber I, Tyndall A, Schifferli JA. Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody- negative patients. Arthritis Rheum 1999;42:187-8.
8. Sinico RA, Radice A, Ikehata M, Giammarresi G, Corace C, Arrigo G, et al. Anti-CI q autoantibodies in lupus nephritis: prevalence and clinical significance. Ann N Y Acad Sci 2005:1050:193-200.
9. Marto N, Bertolaccini ML, Calabuig E, Hughes GR, Khamashta MA. Anti-C1 q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus. Ann Rheum Dis 2005;64:444-8.
10. Coremans IE, Spronk PE, Bootsma H, Daha MR, van der Voort EA, Kater L, et al. Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus. Am J Kidney Dis 1995;26:595-601.
11. Trendelenburg M, Lopez-Trascasa M, Potlukova E, Moll S, Regenass S, Frémeaux- Bacchi V, et al. Prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. Nephrol Dial Transplant 2006;21:3115-21.
12. Moroni G, Trendelenburg M, Del Papa N, Quaglini S, Raschi E, Panzeri P, et al. Anti- C1q antibodies may help in diagnosing a renal flare in lupus nephritis. Am J Kidney Dis 2001;37:490-8.
13. Kumar A, Gupta R, Varghese T, Pande RM, Singal VK, Garg OP. Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus. Indian J Med Res 1999;1110:90-3.
14. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
15. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004;15:241-50.