Carbetocin versus syntometrine in prevention of post-partum hemorrhage following vaginal delivery

Journal of Obstetrics and Gynaecology Research

Volumn 35, Issue 1, 2009, Pages 48-54

  Nirmala, Kampan ^a,b   Zainuddin, Ani Amelia ^b   Ghani, Nur Azurah Abdul ^b   Zulkifli, Syed ^b   Jamil, Mohd Abdul ^b  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Blood loss; Carbetocin; Oxytocic agent; Post partum hemorrhage; Syntometrine

Indexed keywords

CARBETOCIN; ERGOMETRINE PLUS OXYTOCIN; HEMOGLOBIN; OXYTOCIC AGENT;

ABDOMINAL PAIN; ARTICLE; BACKACHE; BLOOD TRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLUSHING; HEADACHE; HEAT; HIGH RISK PATIENT; HUMAN; INCIDENCE; INTRAPARTUM HEMORRHAGE; MAJOR CLINICAL STUDY; METALLIC TASTE; NAUSEA; POSTPARTUM HEMORRHAGE; RISK FACTOR; SIDE EFFECT; SINGLE DRUG DOSE; SWEATING; TASTE DISCRIMINATION; TREATMENT OUTCOME; TREMOR; UTERUS FUNDUS HEIGHT; VAGINAL DELIVERY; VITAL SIGN; VOMITING;

ERGONOVINE; FEMALE; HUMANS; OXYTOCICS; OXYTOCIN; POSTPARTUM HEMORRHAGE; PREGNANCY; PROSPECTIVE STUDIES;

EID: 58849106406     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2008.00829.x     Document Type: Article

References (26)

1. Abou ZC, Royston E. Maternal Mortality:Global Factbook. Geneva : World Health Organisation, 1991.
2. Department of Health. Why Mothers Die. A Report on the Confidential Enquiries into Maternal Deaths in the United Kingdom London. 1997-1999. London : RCOG Press, 2001.
3. Ministry of Health Malaysia. Report on the confidential enquiries into maternal deaths in Malaysia 1997-2000. Kuala Lumpur : Ministry of Health Malaysia, 2005.
4. World Health Organization. Global Estimates of Maternal Mortality for 2000: Results of An In-depth Review, Analysis and Estimation Strategy. Geneva : World Health Organization, 2004.
5. Prendiville W, Elbourne D, Chalmers I et al. The effects of routine oxytocic administration in the management of the third stage of labour: An overview of the evidence from controlled trials. Br J Obstet Gynaecol 1998 95 : 3 16.
6. Selo-Ojeme DO. Review primary postpartum haemorrhage. Int J Obstet Gynaecol 2002 22 : 463 469.
7. Dansereau J, Joshi AK, Helewa ME et al. Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section. Am J Obstet Gynaecol 1999 180 : 670 676.
8. Khan GQ, John IS, Chan T et al. Abu Dhabi third stage trial: Oxytocin versus syntometrine in the active management of the third stage of labour. Eur J Obstet Gynaecol Rep Biol 1995 58 : 147 151.
9. Van Dogen PWJ, Verbruggen MM, de Groot AN et al. Ascending dose tolerance study of intramuscular carbetocin administered after normal vaginal birth. Eur J Obstet Gynaecol Rep Biol 1998 77 : 181 187.
10. Boucher M, Nimrod CA, Tawagi GF et al. Comparison of carbetocin and oxytocin for the prevention of postpartum haemorrhage following vaginal delivery: A double-blind randomized trial. J Obstet Gynecol Canada 2003 25 : 515.
11. Hunter DJS, Patricia S, Wassenaar W et al. Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus. Clin Pharmacol Ther 1992 52 : 60 67.
12. Boucher M, Horbay GLA, Griffin P et al. Double-blind, randomized comparison of the effect of carbetocin and oxytocin on intraoperative blood loss and uterine tone of patients undergoing caesarean section. J Perinatol 1998 18 : 202 207.
13. Leung SW, Ng PS, Wong WY et al. A randomised trial of carbetocin versus syntometrine in the management of the third stage of labour. BJOG Int J Obstet Gynaecol 2006 113 : 1459 1464.
14. Hill LM, Breckle R, Thomas MI et al. Polyhydramnios: Ultrasonically detected prevalence and neonatal outcome. Obstet Gynecol 1987 69 : 21.
15. Phelan JP, Smith CV, Broussard P et al. Amniotic fluid volume assessment with the four-quadrant technique at 36-42 weeks' gestation. J Reprod Med 1987 32 : 540.
16. deGroot AN. Prevention of postpartum haemorrhage. Ballieres Clin Obstet Gynaecol 1995 9 : 619 631.
17. Shuurmans N, MacKinnon C, Lane C et al. Prevention and management of postpartum haemorrhage. SOGC Clin Pract Guidelines 2000 22 : 271 281.
18. Selo-Ojeme DO, Okonofua FE. Risk factors for primary postpartum haemorrhage. Arch Gynaecol Obst 1997 259 : 179 187.
19. Stones RW, Paterson CM, Saunders N et al. Risk factors for major obstetric haemorrhage. Arch Gynaecol Obst 1997 259 : 179 187.
20. Razvi K, Chua S, Arulkumaran S et al. A comparison between visual estimation and laboratory determination of blood loss during the third stage of labour. Aust N Z J Obst Gynaecol Clin North Am 1996 22 : 283 302.
21. Newton M, Mosey LM, Egli GE et al. Blood loss during and immediately after delivery. Obstet Gynaecol 1961 17 : 9 18.
22. Sweeney G, Holbrook AM, Levine M et al. Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, in nonpregnant women. Curr Ther Res 1990 47 : 528 540.
23. Hunter DJS, Schulz P, Wassenaar W. Effect of carbetocin, a long acting oxytocin analogue on the postpartum uterus. Clin Pharmacol Ther 1992 52 : 60 67.
24. Sorbe B. Active pharmacologic management of the third stage of labour. A comparison of oxytocin and ergometrine. Obstet Gynaecol 1978 17 : 694 647.
25. Hammar M, Bostrom K, Borgvall B. Comparison between the influence of methylergometrine and oxytocin on the incidence of retained placenta in the third stage of labour. Gynaecol Obstet Inves 1990 30 : 91 93.
26. Yuen PM, Chan NST, Yim SF et al. A randomised double blind comparison of syntometrine and syntocinon in the management of the third stage of labour. Br J Obstet Gynaecol 1995 102 : 377 380.