A study of the teratogenic and fetotoxic effects of large doses of chlordiazepoxide used for self-poisoning by 35 pregnant women

Toxicology and Industrial Health

Volumn 24, Issue 2, 2008, Pages 41-51

  Gidai, J ^a   Acs N ^b   Banhidy F ^b   Czeizel, Ae ^a  

^a FOUNDATION FOR THE COMMUNITY CONTROL OF HEREDITARY DISEASES   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

chlordiazepoxide; cognitive and behavioral development; congenital abnormalities; intrauterine growth retardation; suicide attempt during pregnancy

Indexed keywords

CHLORDIAZEPOXIDE; HYPNOTIC SEDATIVE AGENT; DIAZEPAM; MEPROBAMATE; NITRAZEPAM;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CHEMICALLY INDUCED DISORDER; CONGENITAL MALFORMATION; DOSE RESPONSE; FEMALE; HUMAN; HUNGARY; INFANT; INTRAUTERINE GROWTH RETARDATION; NEWBORN; PREGNANCY; PREGNANCY OUTCOME; PREGNANT WOMAN; PRENATAL EXPOSURE; STATISTICS; SUICIDE ATTEMPT; BEHAVIOR; BIRTH WEIGHT; CHILD; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DRUG OVERDOSE; FETAL ALCOHOL SYNDROME; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; HEART ATRIUM SEPTUM DEFECT; INGUINAL HERNIA; MALE; PES EQUINOVARUS; PRENATAL DEVELOPMENT; PRENATAL DRUG EXPOSURE; PREVALENCE; RESPIRATORY TRACT MALFORMATION; SELF POISONING; SIBLING; TERATOGENESIS; TIME PERCEPTION; TOXICOLOGY; URETEROPELVIC JUNCTION OBSTRUCTION;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHLORDIAZEPOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL GROWTH RETARDATION; HUMANS; HUNGARY; HYPNOTICS AND SEDATIVES; INFANT; INFANT, NEWBORN; PREGNANCY; PREGNANCY OUTCOME; PREGNANT WOMEN; PRENATAL EXPOSURE DELAYED EFFECTS; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 58849105580     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708089018     Document Type: Article

References (34)

1. Bracken MB, Holford TR (1981) Exposure to prescribed drugs in pregnancy and association with congenital malformations. Obstet Gynecol 58: 336–344.
2. Briggs GG, Freeman RK, Yaffe S (2005) Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, seventh ed. Baltimore: Lippincott Williams and Wilkins.
3. Buttar HS (1980) Effects of chlordiazepoxide on the pre- and postnatal development of rats. Toxicology 17: 311–321.
4. Crombie DL, Pinsent RJ, Fleming DM, Rumean-Rouquette C, Goujard J, Huel G (1975) Fetal effects of tranquilizers in pregnancy. N Engl J Med 293: 198–199.
5. Czeizel AE (1986) Self-poisoning as a model for the study of mutagenicity and teratogenicity of chemicals on human beings. In: C Ramel, B Lambert, J Magnusson (eds), Genetic Toxicology of Environmental Chemicals. Part B: Genetic Effects and Applied Mutagenesis. New York: Alan R. Liss, pp. 237–244.
6. Czeizel AE, Gidai J, Petik D, Timmermann G, Puhó EH (2008) Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Toxicol Ind Health 24: 11–28.
7. Czeizel AE, Lendvay A (1989) Attempted suicide and pregnancy. Am J Obstet Gynecol 161: 497 (only).
8. Czeizel AE, Mosonyi A (1997) Monitoring of early human fetal development in women exposed to large doses of chemicals. Environ Mol Mutagen 30: 240–244.
9. Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J (2004a) A population-based case-control study of oral chlordiazepoxide use during pregnancy and risk of congenital abnormalities. Neurotoxicol Teratol 26: 593–598.
10. Czeizel AE, Petik D, Puho E (2004b) Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Cent Eur J Public Health 12: 179–183.
11. Czeizel AE, Rockenbauer M Siffel, Cs, Varga, E (2001) Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 63: 176–185.
12. Czeizel AE, Szentesi I, Szekeres I, Glauber A, Bucski P, Molnár G (1984) Pregnancy outcome and health conditions of offspring of self-poisoned pregnant women. Acta Paediatr Hung 25: 209–236.
13. Czeizel AE, Szentesi I, Szekeres I, Molnár G, Glauber A, Bucski P (1988) A study of adverse effects on the progeny after intoxication during pregnancy. Arch Toxicol 62: 1–7.
14. Czeizel AE, Tomcsik J, Tímár L (1997) Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstet Gynecol 90: 195–201.
15. FDA : Food and Drug Administration (1980) Fetal risk summary. Fed Regist 44: 37434–37467.
16. Friedman JM, Polifka JE (1996) The Effects of Drugs on the Fetus and Nursing Infant. Baltimore: Johns Hopkins Univ Press.
17. Guram MS, Gill TS, Geber WF (1982) Comparative teratogenicity of chlordiazepoxide, amitriptyline, and a combination of the two compounds in the fetal hamster. Neurotoxicology 3: 83–90.
18. Hartz SC, Heinonen OP, Shapiro S, Siskind V, Slone D (1975) Antenatal exposure to meprobomate and chlordiazepoxide in relation to malformations, mental development and childhood mortality. N Engl J Med 292: 726–728.
19. Heinonen OP, Slone D, Shapiro S (1977) Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group.
20. Jorgensen NP, Thurmann-Nielsen E, Walstad RA (1988) Pharmacokinetics and distribution of diazepam and oxazepam in early pregnancy. Acta Obstet Gynecol Scand 67: 493–497.
21. Kanto JH (1982) Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. Drugs 23: 354–380.
22. Kanto J, Erkkola R, Sellman R (1973) Accumulation of diazepam and N-demethyldiazepam in the fetal blood during labour. Ann Clin Res 5: 375–379.
23. Kullander S, Kallen B (1976) A prospective study of drugs and pregnancy. I. Psychopharmaca. Acta Obstet Gynecol Scand 55: 25–33.
24. Lendvay A, Czeizel AE (1992) A behavioral teratologic study on offspring of self-poisoned pregnant women. Acta Paediatr Hung 32: 347–369.
25. Milkovich L, Van den Berg BJ (1974) Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development. N Engl J Med 291: 1268–1271.
26. Rosa F (1993) cit. Briggs, GG, Friedman, RK, Yaffe, SJ (2005) Drugs in Pregnancy and Lactation, seventh ed. Philadelphia: Lippincott Williams and Wilkins.
27. Rothman KJ, Fyler DC, Goldblatt A, Keridberg MB (1979) Exogenous hormones and other drug exposures of children with congenital heart disease. Am J Epidemiol 109: 433–439.
28. Saito H, Kobayashu S, Takeno S, Sakai T (1984) Fetal toxicity of benzodizepines in rats. Res Commun Clin Pathol Pharmacol 46: 437–377.
29. Shepard TH, Lemire RJ (2004) Catalog of Teratogenic Agents, eleventh ed. Baltimore: Johns Hopkins Univ. Press.
30. Stirrat GM, Edington DJ, Berry DJ (1974) Transplacental passage of chlordiazepoxide. Br Med J 2: 719 (only).
31. Szegal B. (1980) Diagnostic of psychomotor development. Hung Psychol 2: 148–188.
32. Usdin E, Skolnick P, Tallman JF (1982) Pharmacology of Benzodiazepines. London: Macmillan.
33. Vitéz M, Korányi G, Gönczy E, Rudas T, Czeizel A (1984) A semiquantitative score system for epidemiological studies of fetal alcohol syndrome. Am J Epidemiol 119: 301–308.
34. Wyss S, Maier C (1960) Erfahrungen mit dem neuen Psyhosedativum “Librium” (Ro 5-0690) bei einem internistischen Krankengut. Schweiz Med Wochenschr 45: 1293–1296.