The Singapore 5-Fluorouracil Trabeculectomy Study. Effects on Intraocular Pressure Control and Disease Progression at 3 Years

Ophthalmology

Volumn 116, Issue 2, 2009, Pages 175-184

  Wong, Tina T ^a   Khaw, Peng T ^c   Aung, Tin ^a,b   Foster, Paul J ^c   Htoon, Hla Myint ^a   Oen, Francis T S ^a   Gazzard, Gus ^c   Husain, Rahat ^c   Devereux, Joe G ^c   Minassian, Darwin ^c   Tan, Say Beng ^d   Chew, Paul T K ^a,b   Seah, Steve K L ^a  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

^d Clinical Trials and Epidemiology Research Unit   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; FLUOROURACIL; PLACEBO; PREDNISONE ACETATE; STEROID;

ADULT; ARTICLE; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; CONJUNCTIVAL HEMORRHAGE; CONJUNCTIVITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FATALITY; DRUG SAFETY; DRUG TREATMENT FAILURE; ECTROPION; ENDOPHTHALMITIS; EYE DISEASE; FEMALE; FOLLOW UP; HUMAN; HYPOTONY MACULOPATHY; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; MALE; OPEN ANGLE GLAUCOMA; OPTIC DISK; OPTIC DISK DAMAGE; OPTIC NERVE DISEASE; OUTCOME ASSESSMENT; PEROPERATIVE CARE; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PTOSIS; RANDOMIZED CONTROLLED TRIAL; REOPERATION; RETINA BLOOD VESSEL OCCLUSION; RETINA DETACHMENT; RETINA DISEASE; RETINA HEMORRHAGE; SINGAPORE; SUBCONJUNCTIVAL HE; TRABECULECTOMY; TREATMENT OUTCOME; TREATMENT RESPONSE; UVEITIS; VISUAL FIELD DEFECT;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; GLAUCOMA, ANGLE-CLOSURE; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; OPTIC DISK; PROSPECTIVE STUDIES; RISK; SINGAPORE; TRABECULECTOMY; VISUAL FIELDS;

EID: 58849102294     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2008.09.049     Document Type: Article

References (41)

1. Khaw P.T., Ward S., Porter A., et al. The long-term effects of 5-fluorouracil and sodium butyrate on human Tenon's fibroblasts. Invest Ophthalmol Vis Sci 33 (1992) 2043-2052
2. Khaw P.T., Sherwood M.B., MacKay S.L., et al. Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol 110 (1992) 1150-1154
3. Khaw P.T., Doyle J.W., Sherwood M.B., et al. Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. Arch Ophthalmol 111 (1993) 263-267
4. Khaw P.T., Doyle J.W., Sherwood M.B., et al. Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit. Ophthalmology 100 (1993) 367-372
5. Smith M.F., Sherwood M.B., Doyle J.W., and Khaw P.T. Results of intraoperative 5-fluorouracil supplementation on trabeculectomy for open-angle glaucoma. Am J Ophthalmol 114 (1992) 737-741
6. Fluorouracil Filtering Surgery Study Group. Fluorouracil Filtering Surgery Study one-year follow-up. Am J Ophthalmol 108 (1989) 625-635
7. Kitazawa Y., Kawase K., Matsushita H., and Minobe M. Trabeculectomy with mitomycin: a comparative study with fluorouracil. Arch Ophthalmol 109 (1991) 1693-1698
8. Skuta G.L., Beeson C.C., Higginbotham E.J., et al. Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. Ophthalmology 99 (1992) 438-444
9. AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 3. Baseline characteristics of black and white patients. Ophthalmology 105 (1998) 1137-1145
10. Musch D.C., Lichter P.R., Guire K.E., et al., CIGTS Study Group. The Collaborative Initial Glaucoma Treatment Study: study design, methods, and baseline characteristics of enrolled patients. Ophthalmology 106 (1999) 653-662
11. Schulzer M., and Normal Tension Glaucoma Study Group. Intraocular pressure reduction in normal-tension glaucoma patients. Ophthalmology 99 (1992) 1468-1470
12. Collaborative Normal-Tension Glaucoma Study Group. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J Ophthalmol 126 (1998) 487-497
13. Heijl A., Leske M.C., Bengtsson B., et al., Early Manifest Glaucoma Trial Group. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120 (2002) 1268-1279
14. Brandt J.D., Beiser J.A., Kass M.A., Gordon M.O., and Ocular Hypertension Treatment Study (OHTS) Group. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 108 (2001) 1779-1788
15. Gordon M.O., Beiser J.A., Brandt J.D., et al., Ocular Hypertension Treatment Study Group. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120 (2002) 714-720
16. Congdon N., Wang F., and Tielsch J.M. Issues in the epidemiology and population-based screening of primary angle-closure glaucoma. Surv Ophthalmol 36 (1992) 411-423
17. Shiose Y. Intraocular pressure: new perspectives. Surv Ophthalmol 34 (1990) 413-435
18. Iwase A., Suzuki Y., Araie M., et al., Tajimi Study Group, Japan Glaucoma Society. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology 111 (2004) 1641-1648
19. Wong J.S., Yip L., Tan C., and Chew P. Trabeculectomy survival with and without intra-operative 5-fluorouracil application in an Asian population. Aust N Z J Ophthalmol 26 (1998) 283-288
20. Chylack Jr. L.T., Wolfe J.K., Singer D.M., et al., Longitudinal Study of Cataract Study Group. The Lens Opacification Classification System III. Arch Ophthalmol 111 (1993) 831-836
21. Fleiss J.L. General design issues in efficacy, equivalency and superiority trials. J Periodontal Res 27 (1992) 306-313
22. Grambsch P.M., and O'Brien P.C. The effects of transformations and preliminary tests for non-linearity regression. Stat Med 10 (1991) 697-709
23. Tham C.C., Lai J.S., Poon A.S., et al. Results of trabeculectomy with adjunctive intraoperative mitomycin C in Chinese patients with glaucoma. Ophthalmic Surg Lasers Imaging 37 (2006) 33-41
24. Singh K., Mehta K., Shaikh N.M., et al. Primary Trabeculectomy Antimetabolite Study Group. Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil: prospective randomized clinical trial. Ophthalmology 107 (2000) 2305-2309
25. WuDunn D., Cantor L.B., Palanca-Capistrano A.M., et al. A prospective randomized trial comparing intraoperative 5-fluorouracil vs mitomycin C in primary trabeculectomy. Am J Ophthalmol 134 (2002) 521-528
26. Joshi A.B., Parrish RK I.I., and Feuer W.F. 2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. J Glaucoma 14 (2005) 172-174
27. Siriwardena D., Edmunds B., Wormald R.P., and Khaw P.T. National survey of antimetabolite use in glaucoma surgery in the United Kingdom. Br J Ophthalmol 88 (2004) 873-876
28. Liu L., Siriwardena D., and Khaw P.T. Australia and New Zealand survey of antimetabolite and steroid use in trabeculectomy surgery. J Glaucoma 17 (2008) 423-430
29. Husain R., Aung T., Gazzard G., et al. Effect of trabeculectomy on lens opacities in an East Asian population. Arch Ophthalmol 124 (2006) 787-792
30. Adelman R.A., Brauner S.C., Ashfari N.A., and Grosskreutz C.L. Cataract formation after initial trabeculectomy in young patients. Ophthalmology 110 (2003) 625-629
31. AGIS Investigators. The Advanced Glaucoma Intervention Study, 8: Risk of cataract formation after trabeculectomy. Arch Ophthalmol 119 (2001) 1771-1779
32. Gazzard G., Foster P.J., Devereux J.G., et al. Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas. Br J Ophthalmol 87 (2003) 720-725
33. Tielsch J.M., Katz J., Sommer A., et al. Hypertension, perfusion pressure, and primary open-angle glaucoma: a population-based assessment. Arch Ophthalmol 113 (1995) 216-221
34. Leske M.C., Connell A.M., Schachat A.P., and Hyman L. The Barbados Eye Study: prevalence of open angle glaucoma. Arch Ophthalmol 112 (1994) 821-829
35. Wu S.Y., and Leske M.C. Associations with intraocular pressure in the Barbados Eye Study. Arch Ophthalmol 115 (1997) 1572-1576
36. Mitchell P., Hourihan F., Sandbach J., and Wang J.J. The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 106 (1999) 2010-2015
37. Moss S.E., Klein B.E., and Klein B.E. Ocular factors in the incidence and progression of diabetic retinopathy. Ophthalmology 101 (1994) 77-83
38. O'Brien C., Saxton V., Crick R.P., and Meire H. Doppler carotid artery studies in asymmetric glaucoma. Eye 6 (1992) 273-276
39. Yamazaki Y., and Drance S.M. The relationship between progression of visual field defects and retrobulbar circulation in patients with glaucoma. Am J Ophthalmol 124 (1997) 287-295
40. Foster P.J., Machin D., Wong T.Y., et al. Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study. Invest Ophthalmol Vis Sci 44 (2003) 3885-3891
41. Wells A.P., Cordeiro M.F., Bunce C., and Khaw P.T. Cystic bleb formation and related complications in limbus- versus fornix-based conjunctival flaps in pediatric and young adult trabeculectomy with mitomycin C. Ophthalmology 110 (2003) 2192-2197