Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB

Journal of Alzheimer's Disease

Volumn 16, Issue 1, 2009, Pages 29-34

  Nelson, Peter T ^a,b   Kryscio, Richard J ^a   Abner, Erin L ^a   Schmitt, Frederick A ^a   Jicha, Gregory A ^a   Mendiondo, Marta S ^a   Cooper, Greg ^a   Smith, Charles B ^a   Markesbery, William R ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acetycholinesterase; Acetylcholinesterase inhibitors; Alzheimer's disease; Cholinesterase; Dementia with Lewy bodies; Neuropathology

Indexed keywords

CHOLINESTERASE INHIBITOR;

AGED; ALZHEIMER DISEASE; ARTICLE; COGNITION; DIFFUSE LEWY BODY DISEASE; FEMALE; HUMAN; MALE; MENTAL DETERIORATION; MENTAL HEALTH; MINI MENTAL STATE EXAMINATION; PATHOLOGY; PRIORITY JOURNAL; STATISTICAL MODEL;

EID: 58849099937     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-0926     Document Type: Article

References (20)

1. Gruber-Baldini AL, Stuart B, Zuckerman IH, Simoni-Wastila L, Miller R (2007) Treatment of dementia in community-dwelling and institutionalized medicare beneficiaries. J Am Geriatr Soc 55, 1508-1516.
2. Grutzendler J, Morris JC (2001) Cholinesterase inhibitors for Alzheimer's disease. Drugs 61, 41-52.
3. Heidebrink JL (2002) Is dementia with Lewy bodies the second most common cause of dementia? J Geriatr Psychiatry Neurol 15, 182-187.
4. Rahkonen T, Eloniemi-Sulkava U, Rissanen S, Vatanen A, Viramo P, Sulkava R (2003) Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older. J Neurol Neurosurg Psychiatry 74, 720-724.
5. Stern Y, Jacobs D, Goldman J, Gomez-Tortosa E, Hyman BT, Liu Y, Troncoso J, Marder K, Tang MX, Brandt J, Albert M (2001) An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer disease. Arch Neurol 58, 460-465.
6. Williams MM, Xiong C, Morris JC, Galvin JE (2006) Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 67, 1935-1941.
7. Bhasin M, Rowan E, Edwards K, McKeith I (2007) Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis. Int J Geriatr Psychiatry 22, 890-895.
8. Pakrasi S, Thomas A, Mosimann UP, Cousins DA, Lett D, Burn DJ, O'Brien JT, McKeith IG (2006) Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop? Int J Geriatr Psychiatry 21, 719-721.
9. Shea C, MacKnight C, Rockwood K (1998) Donepezil for treatment of dementia with Lewy bodies: a case series of nine patients. Int Psychogeriatr 10, 229-238.
10. Nelson PT, Jicha GA, Schmitt FA, Liu H, Davis DG, Mendiondo MS, Abner EL, Markesbery WR (2007) Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol 66, 1136-1146.
11. Schmitt FA, Wetherby MM, Wekstein DR, Dearth CM, Markesbery WR (2001) Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project. Gerontologist 41, 716-722.
12. Martins CA, Oulhaj A, de Jager CA, Williams JH (2005) APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model. Neurology 65, 1888-1893.
13. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR (2006) Neuropathologic substrate of mild cognitive impairment. Arch Neurol 63, 38-46.
14. Mirra SS (1997) The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary. Neurobiol Aging 18, S91-94.
15. Cherbuin N, Anstey KJ, Lipnicki DM (2008) Screening for dementia: a review of self- and informant-assessment instruments. Int Psychogeriatr 20, 431-458.
16. Tombaugh TN, McIntyre NJ (1992) The mini-mental state examination: a comprehensive review. J Am Geriatr Soc 40, 922-935.
17. Mendiondo MS, Ashford JW, Kryscio RJ, Schmitt FA (2000) Modelling mini mental state examination changes in Alzheimer's disease. Stat Med 19, 1607-1616.
18. Olichney JM, Galasko D, Salmon DP, Hofstetter CR, Hansen LA, Katzman R, Thal LJ (1998) Cognitive decline is faster in Lewy body variant than in Alzheimer's disease. Neurology 51, 351-357.
19. Kraybill ML, Larson EB, Tsuang DW, Teri L, McCormick WC, Bowen JD, Kukull WA, Leverenz JB, Cherrier MM (2005) Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology 64, 2069-2073.
20. Samuel W, Caligiuri M, Galasko D, Lacro J, Marini M, McClure FS, Warren K, Jeste DV (2000) Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: a preliminary study. Int J Geriatr Psychiatry 15, 794-802.