A study of teratogenic and fetotoxic effects of large doses of meprobamate used for a suicide attempt by 42 pregnant women

Toxicology and Industrial Health

Volumn 24, Issue 2, 2008, Pages 97-107

  Timmermann, G ^a   Acs N ^b   Banhidy F ^b   Czeizel, Ae ^a  

^a FOUNDATION FOR THE COMMUNITY CONTROL OF HEREDITARY DISEASES   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

birth weight; cognitive and behavioral development; congenital abnormalities; meprobamate; pregnancy age; suicide attempt during pregnancy

Indexed keywords

HYPNOTIC SEDATIVE AGENT; MEPROBAMATE; DIAZEPAM; METOPROLOL; PHENOBARBITAL; PROMETHAZINE;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CHILD DEVELOPMENT; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; FETUS DEVELOPMENT; HUMAN; INFANT; MALE; METHODOLOGY; NEWBORN; PREGNANCY; PREGNANT WOMAN; PRENATAL EXPOSURE; SUICIDE ATTEMPT; TOXICOLOGY; BEHAVIOR; BIRTH WEIGHT; CHILD; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CRYPTORCHISM; DRUG OVERDOSE; FETOTOXICITY; FETUS; FETUS GROWTH; GESTATIONAL AGE; HIP DYSPLASIA; HUNGARY; NEUROTOXICITY; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRENATAL GROWTH; SELF POISONING; SIBLING; TERATOGENESIS; TIME PERCEPTION;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD DEVELOPMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEVELOPMENT; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; INFANT, NEWBORN; MALE; MEPROBAMATE; PREGNANCY; PREGNANT WOMEN; PRENATAL EXPOSURE DELAYED EFFECTS; SUICIDE, ATTEMPTED; TOXICOLOGY; YOUNG ADULT;

EID: 58849092469     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708089015     Document Type: Article

References (44)

1. Adrian MJ (1963) The birth of a monster following ingestion of meprobamate by the mother: cause or coincidence? Bull Féd Soc Gynécol Obstét Fr 15: 121 – 122.
2. Belafsky HA Breslow S Hirsch LM Shangold JE Stahl MB (1969) Meprobamate during pregnancy. Obstet Gynecol 34: 378 – 386.
3. Bertrand M (1960) Effets du meprobamate sur l'evolution de la gestation chez la ratte. C R Soc Biol (Paris) 151: 2309 – 2311.
4. Bogdanoff B Rorke LB Yanoff M Warren WS (1972) Brain and eye abnormalities: possible sequelae to prenatal use of multiple drugs including LSD. Am J Dis Child 123: 145 – 148.
5. Brar BS (1969) The effect of meprobamate on fertility gestation and offspring viability and development of mice. Arch Int Pharmacodyn Thér 177: 416 – 422.
6. Briggs GG Freeman RK Yaffe S (2005) Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, seventh ed. Baltimore : Lippincott Williams and Wilkins.
7. Caldwell MB Spille DF (1964) Effect of rat progeny of daily administration of meprobamate during pregnancy and lactation. Nature (Lond) 202: 832 – 833.
8. Clavert J (1963) Etude de l,action du méprobamate sur la formation de l,embyon. C R Soc Biol (Paris) 157: 1481 – 1483.
9. Crombie DL Pinsent RJ Fleming DM Rumeau–Rouquette C Goujard J Huel G (1975) Fetal effects of tranquilizers in pregnancy. N Engl J Med 293: 198 – 199.
10. Czeizel AE (1986) Self-poisoning as a model for the study of mutagenicity and teratogenicity of chemicals on human beings. In: C Ramel B Lambert J Magnusson (eds), Genetic Toxicology of Environmental Chemicals. Part B: Genetic Effects and Applied Mutagenesis. New York : Alan R. Liss, pp. 237–244.
11. Czeizel AE (1994) Budapest registry of self-poisoned patients. Mutat Res 312: 157 – 163.
12. Czeizel AE Evans JA Kodaj I Lenz W (1994) Congenital Limb Deficiencies. Genetic and Teratologic Epidemiologic Studies. Budapest : Akadémiai Kiadó.
13. Czeizel AE Gidai J Petik D Timmermann G Puhó EH (2008) Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Toxicol Ind Health 24: 11 – 28.
14. Czeizel AE Lendvay A (1989) Attempted suicide and pregnancy. Am J Obstet Gynecol 161: 497.
15. Czeizel AE Mosonyi A (1997) Monitoring of early human fetal development in women exposed to large doses of chemicals. Environ Mol Mutagen 30: 240 – 244.
16. Czeizel AE Petik D Puho E (2004) Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Cent Eur J Public Health 12: 179 – 183.
17. Czeizel AE Rockenbauer M Siffel, Cs, Varga, E (2001) Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 63: 176 – 185.
18. Czeizel AE Szentesi I Szekeres I Glauber A Bucski P Molnár C (1984) Pregnancy outcome and health conditions of offspring of self-poisoned pregnant women. Acta Paediatr Hung 25: 209 – 236.
19. Czeizel AE Szentesi I Szekeres I Molnár G Glauber A Bucski P (1988a) A study of adverse effects on the progeny after intoxication during pregnancy. Arch Toxicol 62: 1 – 7.
20. Czeizel AE Telegdi L Tusnady G (1988b) Multiple Congenital Abnormalities. Budapest : Akadémiai Kiadó.
21. Czeizel AE Tomcsik J Tímár L (1997b) Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstet Gynecol 90: 195 – 201.
22. Daube JR Chow DM (1966) Lissencephaly: two cases. Neurology 16: 179 – 182.
23. Davis JM Bartlett E Termini BA (1968) Overdosage of psychotropic drugs: a review I. Major and minor tranquilizers. Dis Nerv Syst 29: 157 – 169.
24. Favre-Tissot M Broussole P Robert JM Dumont L (1964) An original clinical study of the pharmacologic-teratogenic relationship. Ann Méd-Psychol 1: 389 – 394 (in French).
25. FDA : Food and Drug Administration (1980) Fetal risk summary. Fed Regist 44: 37434 – 37467.
26. Gauthier J Monnet P Salle B (1965) Malfacans type ectromélie. Discussion sur le role: tératogéne de médications au cours de la grossesse. Pédiatrie 20: 489 – 501.
27. Hartz SC Heinonen OP Shapiro S Siskind V Slone O (1975) Antenatal exposure to meprobomate and chlordiazepoxide in relation to malformations, mental development and childhood mortality. N Engl J Med 292: 726 – 728.
28. Heinonen OP Slone D Shapiro S (1977) Birth Defects and Drugs in Pregnancy. Littleton, MA : Publ. Sciences Group, pp. 336–337.
29. Hoffeld DR Webster RL McNew J (1967) Adverse effects on offspring of tranquillizing drugs during pregnancy. Nature (Lond) 215: 182 – 183.
30. Kletzkin M Berger FM (1971) Influence of mebprobamate on the fetus, fertility and post-natal development. In: H Tuchmann-Duplesses (ed), Malformations Congenitales des Mamiferes. Paris : Masson, pp. 255–272.
31. Kletzkin M Wojciechowski H Margolin S (1966) Tranquillizers in pregnancy and behavioural effects on the offspring. Nature (Lond) 210: 1290 – 1292.
32. Lendvay A Czeizel AE (1992) A behavioural teratologic study on offspring of self-poisoned pregnant women. Acta Paediatr Hung 32: 347 – 369.
33. Milkovich L Van den Berg BJ (1974) Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development. N Engl J Med 291: 1268 – 1271.
34. Murai N (1966) Effect of maternal medication during pregnancy upon behavioral development of offspring. Tohoku J Exp Med 89: 265 – 270.
35. Mutti P Ragucci N (1966). cit. Brar, BS (1969) The effect of meprobamate on fertility, gestation and offspring viability and development of mice. Arch Int Pharmacodyn Thér 177: 416 – 422.
36. Nishikawa M (1963) Effect of meprobamate on the development of the fetus on pregnant mice. Acta Anat Nippon 38: 258 – 260.
37. Pastia A Ionita N (1966) cit Brar, BS (1969) The effect of meprobamate on fertility, gestation and offspring viability and development of mice. Arch Int Pharmacodyn Thér 177: 416 – 422.
38. Product Information. Miltown Wallace Laboratories. 2000. Cit. Briggs, GG, Friedman, RK, Yaffe, SJ. (2005) Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, seventh ed. Baltimore: Lippincott Williams and Wilkins, p. 1005.
39. Ringrose CAD (1972) The hazard of neurotropic drugs in the fertile years. Can Med Assoc J 106: 1058 – 1059.
40. Rosa F (1993) cit. Briggs, GG, Friedman, RK, Yaffe, SJ (2005) Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, seventh ed. Baltimore: Lippincott Williams and Wilkins.
41. Szegal B (1980) Diagnostic of psychomotor development. Hung Psychol 2: 148 – 188.
42. Vaage S Berczy J (1962) Drug-induced abnormalities. Tidsskr Nor Laegeforen 18: 1202 – 1204.
43. Vitéz M Korányi G Gönczy E Rudas T Czeizel AE (1984) A semiquantitative score system for epidemiological studies of fetal alcohol syndrome. Am J Epidemiol 119: 301 – 308.
44. Werboff J Kesner B (1963) Learning deficits of offspring after administration of tranquilizing drugs to the mothers. Nature 197: 106 – 107.