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Volumn 7, Issue 6, 2008, Pages 390-397

Results of a phase II trial of cetuximab plus capecitabine/irinotecan as first-line therapy for patients with advanced and/or metastatic colorectal cancer

Author keywords

Monoclonal antibodies; Quality of life; Targeted therapy; XELIRI

Indexed keywords

CAPECITABINE; CETUXIMAB; IRINOTECAN;

EID: 58849087286     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2008.n.052     Document Type: Article
Times cited : (14)

References (23)
  • 1
    • 85031356467 scopus 로고    scopus 로고
    • Detailed Guide: Colon and Rectum Cancer
    • Available at:, Accessed: June 16, 2008
    • American Cancer Society. Detailed Guide: Colon and Rectum Cancer. What Are the Key Statistics for Colorectal Cancer? Available at: http://www.cancer. org/doc-root/CRI/content/CRI-2-4-1X-What-are-the-key-statistics-for-colon-and- rectum-cancer.asp?sitearea. Accessed: June 16, 2008.
    • What Are the Key Statistics for Colorectal Cancer
  • 2
    • 21844472538 scopus 로고    scopus 로고
    • Results of a phase II open-label study of capecitabine in combination with irinotecan as first-line treatment for metastatic colorectal cancer
    • Cartwright T, Lopez T, Vukelja SJ, et al. Results of a phase II open-label study of capecitabine in combination with irinotecan as first-line treatment for metastatic colorectal cancer. Clin Colorectal Cancer 2005; 5:50-6.
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 50-56
    • Cartwright, T.1    Lopez, T.2    Vukelja, S.J.3
  • 3
    • 84898694962 scopus 로고    scopus 로고
    • Capecitabine plus irinotecan: A highly active first-line treatment for metastatic colorectal cancer (MCRC)
    • Presented at: January 22-24, San Franciso, California. Abstract 228
    • Patt YZ, Lin E, Liebman J, et al. Capecitabine plus irinotecan: a highly active first-line treatment for metastatic colorectal cancer (MCRC). Presented at: the American Society of Clinical Oncology: 2004 Gastrointestinal Cancers Symposium; January 22-24, 2004; San Franciso, California. Abstract 228.
    • (2004) the American Society of Clinical Oncology: 2004 Gastrointestinal Cancers Symposium
    • Patt, Y.Z.1    Lin, E.2    Liebman, J.3
  • 4
    • 0042676659 scopus 로고    scopus 로고
    • Dose escalation and pharmacokinetic study of capecitabine (Xeloda) and irinotecan (CPT-11) in gastrointestinal tumors: Preliminary results
    • Abstract 397
    • DeLord JP, Peirga JY, Dieras V, et al. Dose escalation and pharmacokinetic study of capecitabine (Xeloda) and irinotecan (CPT-11) in gastrointestinal tumors: preliminary results. Proc Am Soc Clin Oncol 2003; 21:100a (Abstract 397).
    • (2003) Proc Am Soc Clin Oncol , vol.21
    • DeLord, J.P.1    Peirga, J.Y.2    Dieras, V.3
  • 5
    • 0036982734 scopus 로고    scopus 로고
    • Capecitabine/irinotecan in colorectal cancer: European early-phase data and planned trials
    • Kerr D. Capecitabine/irinotecan in colorectal cancer: European early-phase data and planned trials. Oncology 2002; 16(suppl):12-5.
    • (2002) Oncology , vol.16 , Issue.SUPPL. , pp. 12-15
    • Kerr, D.1
  • 6
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 95:205-16.
    • (2000) J Natl Cancer Inst , vol.95 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 7
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. JASA 1958; 53:457-81.
    • (1958) JASA , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 8
    • 77953361035 scopus 로고    scopus 로고
    • First-line chemotherapy with irinotecan plus capecitabine for advanced colorectal cancer
    • 18 suppl):633s Abstract 14602
    • Michalaki V, Gennatas C, Gennatas S, et al. First-line chemotherapy with irinotecan plus capecitabine for advanced colorectal cancer. J Clin Oncol 2007; 25(18 suppl):633s (Abstract 14602).
    • (2007) J Clin Oncol , pp. 25
    • Michalaki, V.1    Gennatas, C.2    Gennatas, S.3
  • 9
    • 21344457969 scopus 로고    scopus 로고
    • A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer
    • Rea DW, Nortier JW, Ten Bokkel Huinink WW, et al. A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer. Ann Oncol 2005; 16:1123-32.
    • (2005) Ann Oncol , vol.16 , pp. 1123-1132
    • Rea, D.W.1    Nortier, J.W.2    Ten Bokkel Huinink, W.W.3
  • 10
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz HJ, Van Cutsem E, Khambata-Ford S, et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006; 24:4914-21.
    • (2006) J Clin Oncol , vol.24 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3
  • 11
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22:1201-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3
  • 12
    • 33646143224 scopus 로고    scopus 로고
    • Efficacy and safety of cetuximab/iri- notecan in chemotherapy-refractory metastatic colorectal adenocarcinomas: A clinical practice setting, multicenter experience
    • Gebbia V, Del Prete S, Borsellino N, et al. Efficacy and safety of cetuximab/iri- notecan in chemotherapy-refractory metastatic colorectal adenocarcinomas: a clinical practice setting, multicenter experience. Clin Colorectal Cancer 2006; 5:422-8.
    • (2006) Clin Colorectal Cancer , vol.5 , pp. 422-428
    • Gebbia, V.1    Del Prete, S.2    Borsellino, N.3
  • 13
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetux- imab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetux- imab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-45.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 14
    • 84898694371 scopus 로고    scopus 로고
    • Cetuximab and irinotecan in second- and third-line treatment of advanced colorectal cancer patients
    • Presented at: January 19-21, Orlando, Florida. Abstract 451
    • Cassano A, Basso M, Quirino M, et al. Cetuximab and irinotecan in second- and third-line treatment of advanced colorectal cancer patients. Presented at: the American Society of Clinical Oncology: the 2007 Gastrointestinal Cancers Symposium; January 19-21, 2007; Orlando, Florida. Abstract 451.
    • (2007) the American Society of Clinical Oncology: The 2007 Gastrointestinal Cancers Symposium
    • Cassano, A.1    Basso, M.2    Quirino, M.3
  • 15
    • 67349242264 scopus 로고    scopus 로고
    • Cetuximab with irinotecan as salvage therapy in heavily pretreated patients with metastatic gastric cancer
    • Presented at: January 19-21, Orlando, Florida. Abstract 47
    • Stein A, Al-Batran SE, Arnold D, et al. Cetuximab with irinotecan as salvage therapy in heavily pretreated patients with metastatic gastric cancer. Presented at: the American Society of Clinical Oncology: the 2007 Gastrointestinal Cancers Symposium; January 19-21, 2007; Orlando, Florida. Abstract 47.
    • (2007) the American Society of Clinical Oncology: The 2007 Gastrointestinal Cancers Symposium
    • Stein, A.1    Al-Batran, S.E.2    Arnold, D.3
  • 16
    • 85031350300 scopus 로고    scopus 로고
    • Buzaid A, de Cerqueira Mathias C, Perazzo F, et al. Preliminary data from a phase II study of cetuximab with irinotecan in heavily pretreated patients with epidermal growth factor (EGFR)-expressing metastatic colorectal cancer (mCRC): LABEL. J Clin Oncol 2007; 25(18 suppl):626s (Abstract 14521).
    • Buzaid A, de Cerqueira Mathias C, Perazzo F, et al. Preliminary data from a phase II study of cetuximab with irinotecan in heavily pretreated patients with epidermal growth factor (EGFR)-expressing metastatic colorectal cancer (mCRC): LABEL. J Clin Oncol 2007; 25(18 suppl):626s (Abstract 14521).
  • 17
    • 84898694320 scopus 로고
    • Phase II study of cetuximab with irinotecan in patients with epidermal growth factor (EGFR)-expressing metastatic colorectal cancer (mCRC): LABEL preliminary data
    • Presented at: January, Orlando, Florida. Abstract 293
    • Mathias C, Buzaid A, Perazzo F, et al. Phase II study of cetuximab with irinotecan in patients with epidermal growth factor (EGFR)-expressing metastatic colorectal cancer (mCRC): LABEL preliminary data. Presented at: the American Society of Clinical Oncology: the 2007 Gastrointestinal Cancers Symposium; January 1921, 2007; Orlando, Florida. Abstract 293.
    • (1921) the American Society of Clinical Oncology: The 2007 Gastrointestinal Cancers Symposium , pp. 2007
    • Mathias, C.1    Buzaid, A.2    Perazzo, F.3
  • 18
    • 34547187212 scopus 로고    scopus 로고
    • Biweekly cetuximab (Cet) and irinotecan (Iri) as third-line therapy in patients with advanced colorectal cancer (ACRC)
    • Presented at: January 19-21, Orlando, Florida. Abstract 305
    • Pfeiffer P, Bjerregaard JK, Qvortrup C. Biweekly cetuximab (Cet) and irinotecan (Iri) as third-line therapy in patients with advanced colorectal cancer (ACRC). Presented at: the American Society of Clinical Oncology: the 2007 Gastrointestinal Cancers Symposium; January 19-21, 2007; Orlando, Florida. Abstract 305.
    • (2007) the American Society of Clinical Oncology: The 2007 Gastrointestinal Cancers Symposium
    • Pfeiffer, P.1    Bjerregaard, J.K.2    Qvortrup, C.3
  • 19
    • 33644697486 scopus 로고    scopus 로고
    • Cetuximab and irinotecan/5-fluoroura- cil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma
    • Folprecht G, Lutz MP, Schöffski P, et al. Cetuximab and irinotecan/5-fluoroura- cil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol 2006; 17:450-6.
    • (2006) Ann Oncol , vol.17 , pp. 450-456
    • Folprecht, G.1    Lutz, M.P.2    Schöffski, P.3
  • 20
    • 84898699028 scopus 로고    scopus 로고
    • Heinemann V, Fischer Von Weikersthal L, Moosmann N, et al. Cetuximab + capecitabine + irinotecan (CCI) versus cetuximab + capecitabine + oxaliplatin (CCO) as first line therapy for patients with metastatic colorectal cancer (CRC): preliminary results of a randomized phase II trial of the AIO CRC Study Group. J Clin Oncol 2006; 24(18 suppl):158s (Abstract 3550).
    • Heinemann V, Fischer Von Weikersthal L, Moosmann N, et al. Cetuximab + capecitabine + irinotecan (CCI) versus cetuximab + capecitabine + oxaliplatin (CCO) as first line therapy for patients with metastatic colorectal cancer (CRC): preliminary results of a randomized phase II trial of the AIO CRC Study Group. J Clin Oncol 2006; 24(18 suppl):158s (Abstract 3550).
  • 21
    • 38849095396 scopus 로고    scopus 로고
    • XELIRI plus cetuximab versus XELOX plus cetuximab for first-line therapy of metastatic colorectal cancer (CRC): A randomized trial of the AIO CRC Study Group
    • Presented at: January 19-21, Orlando, Florida. Abstract 278
    • Heinemann V, Moosmann N, Vehling-Kaiser U, et al. XELIRI plus cetuximab versus XELOX plus cetuximab for first-line therapy of metastatic colorectal cancer (CRC): a randomized trial of the AIO CRC Study Group. Presented at: the American Society of Clinical Oncology: the 2007 Gastrointestinal Cancers Symposium; January 19-21, 2007; Orlando, Florida. Abstract 278.
    • (2007) the American Society of Clinical Oncology: The 2007 Gastrointestinal Cancers Symposium
    • Heinemann, V.1    Moosmann, N.2    Vehling-Kaiser, U.3
  • 22
    • 84898693426 scopus 로고    scopus 로고
    • Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
    • Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
  • 23
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007; 25:4779-86.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3


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