Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: Synthesis and biological activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 576-584

  Feng, Zixia ^a   Hellberg, Mark R ^a   Sharif, Najam A ^a   McLaughlin, Marsha A ^a   Williams, Gary W ^a   Scott, Daniel ^a   Wallace, Tony ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

13 Oxa prostaglandin; Glaucoma; Intraocular pressure (IOP)

Indexed keywords

13 OXA 17 (3 TRIFLUOROMETHYL)PHENYL 9,11,15 TRIHYDROXY 18,19,20 TRINOR 5 PROSTADIENOIC ACID; 13 OXA 17 (3 TRIFLUOROMETHYL)PHENYL 9,11,15 TRIHYDROXY 18,19,20 TRINOR 5 PROSTADIENOIC ACID ISOPROPYL ESTER; AL 16049; AL 16082; ALDEHYDE DERIVATIVE; ANTIGLAUCOMA AGENT; BENZOIC ACID DERIVATIVE; BIMATOPROST; FLUPROSTENOL; LATANOPROST; PHOSPHATIDYLINOSITIDE; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2 ALPHA ISOPROPYL ESTER; PROSTAGLANDIN RECEPTOR; TRAVOPROST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EYE IRRITATION; EYE SWELLING; GLAUCOMA; HYPEREMIA; IN VITRO STUDY; INCIDENCE; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MONKEY; NONHUMAN; PUPIL; RABBIT; SECOND MESSENGER;

ADMINISTRATION, TOPICAL; ANIMALS; CATS; DINOPROST; DRUG DISCOVERY; EYE DISEASES; GLAUCOMA; HAPLORHINI; HYPERTENSION; INTRAOCULAR PRESSURE; PROSTAGLANDINS F, SYNTHETIC; PROSTAGLANDINS, SYNTHETIC; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 58749106577     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.070     Document Type: Article

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