Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy

American Journal of Obstetrics and Gynecology

Volumn 200, Issue 2, 2009, Pages 170.e1-170.e7

  Allegaert, Karel ^a   van Mieghem, Tim ^a   Verbesselt, Rene ^a   de Hoon, Jan ^a   Rayyan, Maissa ^a   Devlieger, Roland ^a   Deprest, Jan ^a   Anderson, Brian J ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

amniotic fluid; cefazolin; pharmacokinetics; pregnancy

Indexed keywords

CEFAZOLIN;

AMNION FLUID; ARTICLE; CHORIOAMNIONITIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG HALF LIFE; FEMALE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 58749088537     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2008.08.067     Document Type: Article

References (26)

1. Gyssens I.C. Preventing postoperative infections: current treatment recommendations. Drugs 57 (1999) 175-185
2. Schrag S., Gorwitz R., Fultz-Butts K., and Schuchat A. Prevention of perinatal group B streptococcal disease: revised guidelines from CDC. MMWR Recomm Rep 51 RR-11 (2002) 1-22
3. Vella-Brincat J.W., Begg E.J., Kirkpatrick C.M., Zhang M., Chambers S.T., and Gallangher K. Protein binding of cefazolin is saturable in vivo both between and within patients. Br J Clin Pharmacol 63 (2007) 753-757
4. Anderson G.D. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 44 (2005) 989-1008
5. Philipson A., Stiernstedt G., and Ehrnebo M. Comparison of the pharmacokinetics of cephradine and cefazolin in pregnant and non-pregnant women. Clin Pharmacokinet 12 (1987) 136-144
6. Popovic J., Grujic Z., and Sabo A. Influence of pregnancy on ceftriaxone, cefazolin and gentamicin pharmacokinetics in caesarean vs. non-pregnant sectioned women. J Clin Pharm Ther 32 (2007) 595-602
7. Pacifici G.M. Placental transfer of antibiotics administered to the mother: a review. Int J Clin Pharmacol Ther 44 (2006) 57-63
8. Anderson B.J., Allegaert K., and Holford N.H. Population clinical pharmacology of children: modelling covariate effects. Eur J Pediatr 165 (2006) 819-829
9. Brown C.E., Christmas J.T., and Bawdon R.E. Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. Am J Obstet Gynecol 163 (1990) 938-943
10. Fiore Mitchell T., Pearlman M.D., Chapman R.L., Bhatt-Mehta V., and Faix R.G. Maternal and transplacental pharmacokinetics of cefazolin. Obstet Gynaecol 98 (2001) 1075-1079
11. Deprest J., Jani J., Lewi L., et al. Fetoscopic surgery: encouraged by clinical experience and boosted by instrument innovation. Semin Fetal Neonatal Med 11 (2006) 398-412
12. Deprest J., Jani J., Gratacos E., et al. Fetal intervention for congenital diaphragmatic hernia: the European experience. Semin Perinatol 29 (2005) 94-103
13. Lewi L., Van Schoubroeck D., Gratacos E., Witters I., Timmerman D., and Deprest J. Monochorionic diamniotic twins: complications and management options. Curr Opin Obstet Gynecol 15 (2003) 177-194
14. Duffull S.B., Kirkpatrick C.M., Green B., and Holford N.H. Analysis of population pharmacokinetic data using NONMEM and WinBUGS. J Biopharm Stat 15 (2005) 53-73
15. Efron B., and Tibshirani R. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Statistical Science 1 (1986) 54-77
16. Rattie E.S., and Ravin L.J. Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans. Antimicrob Agents Chemother 7 (1975) 606-613
17. Andrew M.A., Easterling T.R., Carr D.B., et al. Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Clin Pharmacol Ther 81 (2007) 547-556
18. Muller A.E., Dejongh J., Oostvogel P.M., et al. Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes. Am J Obstet Gynecol 198 (2008) 108.e1-108.e6
19. Ci L., Kusuhara H., Adachi M., Schuetz J.D., Takeuchi K., and Sugiyama Y. Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney. Mol Pharmacol 71 (2007) 1591-1597
20. Uwai Y., Saito H., and Inui K. Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet 17 (2002) 125-129
21. Bernard B., Barton L., Abate M., and Ballard C.A. Maternal-fetal transfer of cefazolin in the first twenty weeks of pregnancy. J Infect Dis 136 (1977) 377-382
22. Fellinger E.K., Leavitt B.J., and Hebert J.C. Serum levels of prophylactic cefazolin during cardiopulmonary bypass surgery. Ann Thorac Surg 74 (2002) 1187-1190
23. Arkaravichien W., Tamungklang J., and Arkaravichien T. Cefazolin induced seizures in hemodialysis patients. J Med Assoc Thai 89 (2006) 1981-1983
24. Nau H. Clinical pharmacokinetics in pregnancy and perinatology: II, penicillins. Dev Pharmacol Ther 10 (1987) 174-198
25. Gomez R., Romero R., Nien J.K., et al. Antibiotic administration to patients with preterm premature rupture of membranes does not eradicate intra-amniotic infection. J Matern Fetal Neonatal Med 20 (2007) 167-173
26. Zajicek A., and Giacoia G.P. Obstetric clinical pharmacology: coming of age. Clin Pharmacol Ther 81 (2007) 481-482