Kinetic models for granule nucleation by the immersion mechanism

Powder Technology

Volumn 189, Issue 2, 2009, Pages 177-189

  Hounslow, M J ^a   Oullion, M ^a   Reynolds, G K ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Granulation; Immersion; Layering; Multi scale modelling; Nucleation; Pelletization

Indexed keywords

DRIVING FORCES; IMMERSION; KINETIC MODELLING; LAYERING; MULTI-SCALE MODELLING; PELLETIZATION;

NUCLEATION; PELLETIZING; PHASE INTERFACES; SEISMIC DESIGN; SURFACE TENSION;

GRANULATION;

ARTICLE; GEOMETRY; GRANULATION PROCESS; GRANULE NUCLEATION; IMMERSION; KINETICS; MATHEMATICAL MODEL; PHYSICAL PHENOMENA; SURFACE TENSION; TECHNOLOGY;

EID: 58749087398     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.04.008     Document Type: Article

References (22)

1. Schaefer T., and Mathiesen C. Melt pelletization in a high shear mixer. IX. Effects of binder particle size. International Journal of Pharmaceutics 139 1-2 (1996) 139
2. Abberger T., Seo A., and Schaefer T. The effect of droplet size and powder particle size on the mechanisms of nucleation and growth in fluid bed melt agglomeration. International Journal of Pharmaceutics 249 1-2 (2002) 185
3. Stepanek F., and Ansari M.A. Computer simulation of granule microstructure formation. Chemical Engineering Science 60 14 (2005) 4019
4. Ansari M.A., and Stepanek F. Formation of hollow core granules by fluid bed in situ melt granulation: modelling and experiments. International Journal of Pharmaceutics 321 1-2 (2006) 108
5. Mills P.J.T., Seville J.P.K., Knight P.C., and Adams M.J. The effect of binder viscosity on particle agglomeration in a low shear mixer/agglomerator. Powder Technology 113 1-2 (2000) 140
6. Sastry K.V.S., Dontula P., and Hosten C. Investigation of the layering mechanism of agglomerate growth during drum pelletization. Powder Technology 130 1-3 (2003) 231
7. Venkataramana R., Kapur P.C., and Gupta S.S. Modelling of granulation by a two-stage auto-layering mechanism in continuous industrial drums. Chemical Engineering Science 57 10 (2002) 1685
8. Hapgood K.P., Litster J.D., and Smith R. Nucleation regime map for liquid bound granules. AIChE Journal 49 2 (2003) 350
9. Reynolds G.K., Biggs C.A., Salman A.D., and Hounslow M.J. Non-uniformity of binder distribution in high-shear granulation. Powder Technology 140 3 (2004) 203
10. Scott A.C., Hounslow M.J., and Instone T. Direct evidence of heterogeneity during high-shear granulation. Powder Technology 113 1-2 (2000) 205
11. Hapgood K.P., Litster J.D., Biggs S.R., and Howes T. Drop penetration into porous powder beds. Journal of Colloid and Interface Science 253 2 (2002) 353
12. Denesuk M., Smith G.L., Zelinski B.J.J., Kreidl N.J., and Uhlmann D.R. Capillary penetration of liquid droplets into porous materials. Journal of Colloid and Interface Science 158 1 (1993) 114
13. Barera-Medrano D., Reynolds G.K., Bonsall J., Salman A.D., and Hounslow M.J. An X-ray tomography study of the effect of processing time on granule structure in high shear melt granulation. AIChE Spring National Meetin, Orlando, FL (2006)
14. Bouwman A.M., Henstra M.J., Westerman D., Chung J.T., Zhang Z., Ingram A., Seville J.P.K., and Frijlink H.W. The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation. International Journal of Pharmaceutics 290 1-2 (2005) 129
15. Knight P.C., Instone T., Pearson J.M.K., and Hounslow M.J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technology 97 3 (1998) 246
16. Biggs C.A., Sanders C., Scott A.C., Willemse A.W., Hoffman A.C., Instone T., Salman A.D., and Hounslow M.J. Coupling granule properties and granulation rates in high-shear granulation. Powder Technology 130 1-3 (2003) 162
17. P.K. Le, P. Avontuur, M.J. Hounslow, A.D. Salman, Relationship between early stage of granulation and granule properties: The effect of process parameters, Submitted to Powder Technology, 2008.
18. Chuntonov K.A., Postovalov V.G., and Kesarev A.G. Evaporation of volatile component from intermetallic granule with non-volatile component shell. Vacuum 55 2 (1999) 101
19. Bird R.B., Stewart W.E., and Lighfoot E.N. Transport Phenomena (1960), John Wiley & Sons
20. Kynch G.J.A. A theory of sedimentation. Transactions of the Faraday Society 48 (1952) 166-176
21. MacDonald M.J., Chu C.F., Guilloit P.P., and Ng K.M. A generalized Blake-Kozeny equation for multisized spherical particles. AIChE Journal 37 10 (1991) 1583-1588
22. Knapp R., and Siofroniou M. Advanced documentation of the Mathematica Function NDSolve, Mathematica v 5.2. Wolfram Research (2005)