Problems with GH assays and strategies toward standardization

European Journal of Endocrinology

Volumn 159, Issue SUPPL. 1, 2008, Pages

  Bidlingmaier, Martin ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE;

ACROMEGALY; BINDING AFFINITY; CONFERENCE PAPER; EVIDENCE BASED PRACTICE; GROWTH HORMONE DEFICIENCY; GROWTH INHIBITION; HUMAN; IMMUNOASSAY; PRACTICE GUIDELINE; PROTEIN BINDING; QUALITY CONTROL; STANDARDIZATION; BIOASSAY; BLOOD; CALIBRATION; METHODOLOGY; OSMOLARITY; REVIEW; SENSITIVITY AND SPECIFICITY; STANDARD;

ACROMEGALY; BIOLOGICAL ASSAY; CALIBRATION; HUMAN GROWTH HORMONE; HUMANS; IMMUNOASSAY; OSMOLAR CONCENTRATION; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY;

EID: 58749083753     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-08-0284     Document Type: Conference Paper

References (35)

1. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. Journal of Clinical Endocrinology and Metabolism 1998 83 379-381.
2. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. Journal of Clinical Endocrinology and Metabolism 2000 85 3990-3993.
3. Growth Hormone Research Society and the Pituitary Society. Biochemical assessment and long-term monitoring in patients with acromegaly: statement from a joint consensus conference of the Growth Hormone Research Society and the Pituitary Society. Journal of Clinical Endocrinology and Metabolism 2004 89 3099-3102.
4. Wieringa GE & Trainer PJ. Commentary: harmonizing growth hormone measurements: learning lessons for the future. Journal of Clinical Endocrinology and Metabolism 2007 92 2874-2875.
5. Popii V & Baumann G. Laboratory measurement of growth hormone. Clinica Chimica Acta 2004 350 1-16.
6. Strasburger CJ & Bidlingmaier M. How robust are laboratory measures of growth hormone status? Hormone Metabolic Research 2005 64 (Suppl 2) 1-5.
7. Bidlingmaier F, Geilenkeuser WJ, Kruse R & Rohle G. Our experience with quality control in current growth hormone assays. Hormone Metabolic Research 1991 36 (Suppl 1) 1-4.
8. Morsky P, Tiikkainen U, Ruokonen A & Markkanen H. Problematic determination of serum growth hormone: experience from external quality assurance surveys 1998-2003. Scandinavian Journal of Clinical and Laboratory Investigation 2005 65 377-386.
9. Tanaka T, Tachibana K, Shimatsu A, Katsumata N, Tsushima T, Hizuka N, Fujieda K, Yokoya S & Irie M. A nationwide attempt to standardize growth hormone assays. Hormone Metabolic Research 2005 64 (Suppl 2) 6-11.
10. Seth J, Ellis A & Al-Sadie R. Serum growth hormone measurements in clinical practice: an audit of performance from the UK National External Quality Assessment Scheme. Hormone Metabolic Research 1999 51 13-19.
11. Ekins R. Immunoassay standardization. Scandinavian Journal of Clinical and Laboratory Investigation 1991 205 (Supplement) 33-46.
12. Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocrine Reviews 1991 12 424-449.
13. Baumann G. Growth hormone heterogeneity in human pituitary and plasma. Hormone Metabolic Research 1999 51 2-6.
14. Baumann G, Stolar MW & Buchanan TA. The metabolic clearance, distribution, and degradation of dimeric and monomeric growth hormone (GH): implications for the pattern of circulating GH forms. Endocrinology 1986 119 1497-1501.
15. Chatelain P, Bouillat B, Cohen R, Sassolas G, Souberbielle JC, Ruitton A, Joly MO & Job JC. Assay of growth hormone levels in human plasma using commercial kits: analysis of some factors influencing the results. Acta Paediatrica Scandinavica 1990 370 56-61 (discussion 62).
16. Reiter EO, Morris AH, MacGillivray MH & Weber D. Variable estimates of serum growth hormone concentrations by different radioassay systems. Journal of Clinical Endocrinology and Metabolism 1988 66 68-71.
17. Hayakawa M, Shimazaki Y, Tsushima T, Kato Y, Takano K, Chihara K, Shimatsu A & Irie M. Metabolic effects of 20-kilodalton human growth hormone (20K-hGH) for adults with growth hormone deficiency: results of an exploratory uncontrolled multicenter clinical trial of 20K-hGH. Journal of Clinical Endocrinology and Metabolism 2004 89 1562-1571.
18. Baumann G. Growth hormone binding protein 2001. Journal of Pediatric Endocrinology and Metabolism 2001 14 355-375.
19. Amit T, Youdim MB & Hochberg Z. Clinical review 112: does serum growth hormone (GH) binding protein reflect human GH receptor function? Journal of Clinical Endocrinology and Metabolism 2000 85 927-932.
20. Ebdrup L, Fisker S, Sorensen HH, Ranke MB & Orskov H. Variety in growth hormone determinations due to use of different immunoassays and to the interference of growth hormone-binding protein. Hormone Metabolic Research 1999 51 20-26.
21. Jansson C, Boguszewski C, Rosberg S, Carlsson L & Albertsson-Wikland K. Growth hormone (GH) assays: influence of standard preparations, GH isoforms, assay characteristics, and GH-binding protein. Clinical Chemistry 1997 43 950-956.
22. Hansen TK, Fisker S, Hansen B, Sorensen HH, Christiansen JS, Jorgensen JO & Orskov H. Impact of GHBP interference on estimates of GH and GH pharmacokinetics. Clinical Endocrinology 2002 57 779-786.
23. Pokrajac A, Wark G, Ellis AR, Wear J, Wieringa GE & Trainer PJ. Variation in GH and IGF-I assays limits the applicability of international consensus criteria to local practice. Clinical Endocrinology 2007 67 65-70.
24. Celniker AC, Chen AB, Wert RM Jr & Sherman BM. Variability in the quantitation of circulating growth hormone using commercial immunoassays. Journal of Clinical Endocrinology and Metabolism 1989 68 469-476.
25. Granada ML, Sanmarti A, Lucas A, Salinas I, Carrascosa A, Foz M & Audi L. Assay-dependent results of immunoassayable spontaneous 24-hour growth hormone secretion in short children. Acta Paediatrica Scandinavica 1990 370 63-70 (discussion 71).
26. Markkanen H, Pekkarinen T, Valimaki MJ, Alfthan H, Kauppinen-Makelin R, Sane T & Stenman UH. Effect of sex and assay method on serum concentrations of growth hormone in patients with acromegaly and in healthy controls. Clinical Chemistry 2006 52 468-473.
27. Hauffa BP, Lehmann N, Bettendorf M, Mehls O, Dorr HG, Partsch CJ, Schwarz HP, Stahnke N, Steinkamp H, Said E, Sander S & Ranke MB. Central reassessment of GH concentrations measured at local treatment centers in children with impaired growth: consequences for patient management. European Journal of Endocrinology 2004 150 291-297.
28. Juul A, Bernasconi S, Clayton PE, Kiess W & DeMuinck-Keizer Schrama S. European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency. Hormone Metabolic Research 2002 58 233-241.
29. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML & Stephens PA. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology and Metabolism 2006 91 1621-1634.
30. Melmed S, Casanueva F, Cavagnini F, Chanson P, Frohman LA, Gaillard R, Ghigo E, Ho K, Jaquet P, Kleinberg D, Lamberts S, Laws E, Lombardi G, Sheppard MC, Thorner M, Vance ML, Wass JA & Giustina A. Consensus statement: medical management of acromegaly. European Journal of Endocrinology 2005 153 737-740.
31. GH Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. Journal of Clinical Endocrinology and Metabolism 2000 85 3990-3993.
32. Miller WG, Myers GL & Rej R. Why commutability matters. Clinical Chemistry 2006 52 553-554.
33. Ross HA. Reporting growth hormone assay results in terms of one consensus recombinant standard preparation offers less than optimal reduction of between-method variation. Clinical Chemistry and Laboratory Medicine 2008 46 1334-1335.
34. Trainer PJ, Barth J, Sturgeon C & Wieringa G. Consensus statement on the standardisation of GH assays. European Journal of Endocrinology 2006 155 1-2.
35. Sheppard MC. Growth hormone assay standardization: an important clinical advance. Clinical Endocrinology 2007 66 157-161.