Antimicrobial activity of pentacyclic triterpenes isolated from Acacia mellifera

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 6, Issue 1, 2009, Pages 42-48

  Mutai, C ^a   Bii, C ^a   Rukunga, G ^a   Ondicho, J ^a   Mwitari, P ^a   Abatis, D ^a   Vagias, C ^b   Roussis, V ^b   Kirui, J ^c  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF ATHENS   (Greece)

^c Kenya Medical Training College Nairobi   (Kenya)

Author keywords

Acacia mellifera; Antimicrobial pentacyclic triterpenes; Kenya medicinal plant

Indexed keywords

ACACIA MELLIFERA EXTRACT; BETULIC ACID; HERBACEOUS AGENT; OXOLUPANE 30 AL; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ACACIA; ACACIA MELLIFERA; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BARK; CANDIDA ALBICANS; CANDIDA KRUSEI; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DISK DIFFUSION; DRUG ISOLATION; DRUG STRUCTURE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; KENYA; MICROSPORUM GYPSEUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PLANT STEM; SACCHAROMYCES CEREVISIAE; TRICHOPHYTON MENTAGROPHYTES;

EID: 58649094196     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Akihisa, T., Takamine, Y., Yoshizumi, K., Tokuda, H., Kimura, Y., Ukiya, M., Nakahara, T., Yokochi, T., Ichiishi, E. and Nishino, H. (2002). Microbial transformations of two lupane-type triterpenes and antitumor-promoting effects of the transformation products. J. Nat. Prods 65:278-282.
2. Avles, T.M., Nagem, T.J., De Carvalho, L.H., Krettli, A.U. and Zani, C.L. (1997). Antiplasmodial triterpene from Vernonia brasiliana. Planta Medica 63:554-557.
3. Bringmann, G., Saeb, W., Assi, L. A., Francois, G., Narayanan, A. S. S., Peters, K. and Peters, E. M. (1997). Betulinic Acid. J.Ethnopharmacol. 46:255-257.
4. Corbett, R. E., Cong, A.N.T., Holland, P. T. and Wilkins, A. L. (1987). Extractives from pseudocyphellaria rubella. Ausral. J. Chem. 40:461-468.
5. Dastlik, K.A., Ghisalberti, E.L., Skelton, B.W. and White, A.H. (1991). Structural study of (-)-8-Epi-11-nordriman-9-one. Austral. J. Chem. 44:123-127.
6. Fangs, S., Berry, D. E., Lynn, D. G., Hecht, S. M., Campbell, J. and Lynn, W. S. (1984). The chemistry of toxic principles from Maytenus numerosa. Phytochemistry 23: 631-633.
7. Joshi, K.C., Bansal, T., Murray, R. D. H., Forbes, I. T., Cameron, A. F. and Maltz, A. (1979). Two novel cassane diterpenoids from Acacia jacquemontii. Tetrahedron 35:1449-1453.
8. Kashiwada, Y., Wang, H. K., Nagao, T., Kitanaka, S., Yasuda, I., Fujioka, T., Yamagishi, T., Consentino, L. M., Kozuka, M., Okabe., H., Ikeshiro, Y., Hu, C. Q., and Lee, K. H. (1998). J. Nat. Prods 61: 1090-1095.
9. Katerere, D.R., Gray, A.I., Nash, R.J. and Waigh, R.D. (2003). Pentacyclic triterpenes isolated from African Combretaceae. Phytochemistry 63: 81-88.
10. Kokwaro O. (1976). Medicinal plant of East Africa. East African Literature Bureau Kampala, Nairobi, Dar es Salaam.
11. Malan, E., and Sireeparsad, A. (1995). The structure and synthesis of the first dimeric proteracacadins from Acacia galpinii. Phytochemistry 38: 237-239.
12. Mutai, C., Abatis, D., Vagias, C., Moreau, D., Roussakis, C. and Roussis, V. (2004). Cytotoxic lupane-type triterpenoids from Acacia mellifera. Phytochemistry 65: 1159-1164.
13. Mutai, C., Abatis, D., Vagias, C., Moreau, D., Roussakis, C. and Roussis, V. (2007). Lupane triterpenoids from Acacia mellifera with cytotoxic activity. Molecules 12: 1035-1044.
14. National Committee for Clinical Laboratory Standards (1997). Performance Standards for Antimicrobial Disk Susceptibility Tests. Approved standards M2-A6. National Committee for Clinical Laboratory Standards. Wayne, Pa.
15. Pezzuto, J. M., Dasguta, tapas, K., Kim and Darrick, S. H. L. (1999). U. S. Patent. 19, pp 5-68.
16. Pisha, E., Chai, H., Lee, I. S., Chagwedra, T. E., Fransworth, N.R., Cordell, G. A., Beecher, C. E. W., Fong, H. H. S., Kinghorn, A. D., Brown, D. M., Wani, M. C., Wall, M. E., Hieken, T. J., Gupta, T. K. D. G., and Pezzuto, J. M. (1995). Discovery of betulinic acid as a selective inhibitor of human melanoma. Natural Medicine 1: 1046-1050.
17. Rajic, A., Kweifio-Okai, G., Macrides, T., Sandeman, R.M., Chandler, D.S. and Polya, G.M. (2000). Inhibition of serine proteases by anti-inflammatory triterpenoids. Planta Medica 66: 206-210.
18. Vlientink, J., Van Hoof, L., Lasure, A., Vanden Berghe, D., Rwangabo, P.C. and Mwakiyumwani, J. (1995). Screening of a hundred Rwandese medicinal plants for antibacterial and antiviral properties. J. Ethnopharmacol. 46: 31-47.
19. Weinges, K and Schick H. (1995). Dodecaacetylprodelphinidin B3 from the dried leaves of Ziziphus spinachristi. Phytochemistry, 38(2): 505-507.