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Volumn 351, Issue 1-2, 2009, Pages 103-106

Enantioselective organocatalytic Michael addition of α-substituted cyanoacetates to α,β-unsaturated selenones

Author keywords

Asymmetric organocatalysis; Cyanoacetates; Michael addition; Selenones; Thiourea catalysts

Indexed keywords


EID: 58549116103     PISSN: 16154150     EISSN: 15213897     Source Type: Journal    
DOI: 10.1002/adsc.200800592     Document Type: Article
Times cited : (50)

References (57)
  • 11
    • 38349135345 scopus 로고    scopus 로고
    • For recent reviews on hydrogen bond-facilitated organocatalysis, see: a
    • For recent reviews on hydrogen bond-facilitated organocatalysis, see: a) A. G. Doyle, E. N. Jacobsen, Chem. Rev. 2007, 107, 5713;
    • (2007) Chem. Rev , vol.107 , pp. 5713
    • Doyle, A.G.1    Jacobsen, E.N.2
  • 52
    • 58549086248 scopus 로고
    • for an application of the organoselenones to drug design as biological alkylating agents, see: h
    • for an application of the organoselenones to drug design as biological alkylating agents, see: h) S.-I. Kang, C. P. Spears, J. Med. Chem. 1990, 33, 1547.
    • (1990) J. Med. Chem , vol.33 , pp. 1547
    • Kang, S.-I.1    Spears, C.P.2
  • 53
    • 37549063959 scopus 로고    scopus 로고
    • For a recent review on the enantioselective formation of quaternary stereogenic centers, see
    • For a recent review on the enantioselective formation of quaternary stereogenic centers, see: P. G. Cozzi, R. Hilgraf, N. Zimmermann, Eur. J. Org. Chem. 2007, 5969.
    • (2007) Eur. J. Org. Chem , pp. 5969
    • Cozzi, P.G.1    Hilgraf, R.2    Zimmermann, N.3
  • 54
    • 58549116816 scopus 로고    scopus 로고
    • 3 (94% yield, 34% ee); TBME (93% yield, 38% ee).
    • 3 (94% yield, 34% ee); TBME (93% yield, 38% ee).
  • 55
    • 58549094035 scopus 로고    scopus 로고
    • The reaction carried out with 1f gave 10 in low yield (<25%) and 58% ee.
    • The reaction carried out with 1f gave 10 in low yield (<25%) and 58% ee.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.