Synthesis and anticonvulsant activity of N-(2-hydroxyethyl)amide derivatives

Archiv der Pharmazie

Volumn 342, Issue 1, 2009, Pages 34-40

  Guan, Li Ping ^a   Zhao, Dong Hai ^b   Xiu, Jing Hui ^a   Sui, Xin ^a   Piao, Hu Ri ^a   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b Hubei Province Key Laboratory of Refractories and Ceramics   (China)

Author keywords

Chemically induced models; Maximal electroshock (MES); N (2 hydroxyethyl)amide derivatives; Neurotoxicity

Indexed keywords

3 MERCAPTOPROPIONIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; ANTICONVULSIVE AGENT; BICUCULLINE; CARBAMAZEPINE; GLUTAMATE DECARBOXYLASE; ISONIAZID; N (2 HYDROXYETHYL) STEARAMIDE; N (2 HYDROXYETHYL)AMIDE DERIVATIVE; N (2 HYDROXYETHYL)DECANAMIDE; PALMIDROL; PENTETRAZOLE; STRYCHNINE; THIOSEMICARBAZIDE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; ENZYME ACTIVATION; ENZYME INHIBITION; EPILEPSY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST;

AMIDES; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MICE; NEUROTOXICITY SYNDROMES; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58549115498     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800153     Document Type: Article

References (20)

1. O. J. McNamara in The Pharmacological Basis of Therapeutics, Eds.: J. G. Hardman, L. E. Limbird, A. G. Gilman, McGraw-Hill, New York, 2001, pp. 521-548.
2. W. Löscher, D. Schmidt, Epilepsy Res. 2002, 50, 3-16.
3. R. S. Greenwood, Epilepsia 2000, 41 (Suppl. 2), S42-S52.
4. N. R. Bachur, K. L. Masek, K. L. Melmon, S. Udenfriend, J. Biol. Chem. 1965, 240, 1019-1024.
5. H. H. Schmid, P. C. Schmid, V. Natarajan, Prog. Lipid Res. 1990, 29, 1-43.
6. D. M. Lambert, S. Vandevoorde, G. Diependaele, S. J. Govaerts, A. R. Robert, Epilepsia 2001, 42, 321-327.
7. J. B. Jr. Hester, P. Von Voigtlander, J. Med. Chem. 1979, 22, 1390-1398.
8. J. B. Jr. Hester, A. D. Rudzik, P. Von Voigtlander, J. Med. Chem. 1980, 23, 402-405.
9. R. Okada, N. Negishi, H. Nagaya, Brain Res. 1989, 480, 383-387.
10. R. W. Olsen, J. Neurochem. 1981, 37, 1-13.
11. G. Kale, Epilepsia 1992, 33, S3-S12.
12. W. Loscher, Biochem. Pharmacol. 1979, 28, 1397-1407.
13. U. Sayin, S. Cengiz, T. Altug, Pharmacol. Res. 1993, 28, 325-331.
14. S. Vicini, H. Alho, E. Costa, J. M. Mienville, et al., Proc. Natl. Acad. Sci. U.S.A. 1986, 83, 9269-9273.
15. R. L. Macdonald, J. L. Barker, Neurology 1978, 28, 325-330.
16. R. L. Krall, J. K. Penry, B. G. White, H. J. Kupferberg, E. A. Swinyard, Epilepsia 1978, 19, 409-428.
17. R. J. Porter, J. J. Cereghino, G. D. Gladding, B. J. Hessie, et al., Cleve. Clin. Q. 1984, 51, 293-305.
18. R. Bernasconi, M. Klein, P. Martin, P. Christen, et al., J. Neural. Transm. 1988, 72, 213-233.
19. A. Arnoldi, A. Bonsignori, P. Melloni, L. Merlini, et al., J. Med. Chem. 1990, 33, 2865-2869.
20. W. Löscher, D. Schmidt, Epilepsy Res. 1988, 2, 145-181.