A computer model of the Bystander effect: Effects of individual behaviours on the population response

Applied Radiation and Isotopes

Volumn 67, Issue 3, 2009, Pages 440-442

  Richard, M ^a   Webb, R P ^a   Kirkby, K J ^a   Kirkby, N F ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BYSTANDER EFFECTS; CELL LINES; COMPUTER MODELLING; COMPUTER PROGRAMS; MEV PROTONS; NON-LINEAR;

CELL CULTURE;

ARTICLE; BYSTANDER EFFECT; CELL DIVISION; CELL POPULATION; CELL SURVIVAL; COMPUTER MODEL; CONTROLLED STUDY; HAMSTER; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; X IRRADIATION;

ANIMALS; BYSTANDER EFFECT; CELL SURVIVAL; COMPUTER SIMULATION; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; PROTONS; X-RAYS;

EID: 58549113349     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.06.037     Document Type: Article

References (12)

1. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159 5 (2003) 567-580
2. Mothersill C., and Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71 4 (1997) 421-427
3. Mothersill C.E., Moriarty M.J., and Seymour C.B. Radiotherapy and the potential exploitation of bystander effects. Int. J. Radiat. Oncol. Biol. Phys. 58 2 (2004) 575-579
4. Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low-doses of alpha-particles. Cancer Res. 52 22 (1992) 6394-6396 times Cited: 259 Note 0008-5472.
5. Prise K.M., Folkard M., and Michael B.D. Bystander responses induced by low let radiation. Oncogene 22 45 (2003) 7043-7049
6. Prise K.M., Schettino G., Folkard M., and Held K.D. New insights on cell death from radiation exposure. Lancet Oncol. 6 7 (2005) 520-528
7. Sawant S.G., Randers-Pehrson G., Metting N.F., and Hall E.J. Adaptive response and the bystander effect induced by radiation in c3h 10t(1)/(2) cells in culture. Radiat. Res. 156 2 (2001) 177-180
8. Schettino G., Folkard M., Prise K.M., Vojnovic B., Bowey A.G., and Michael B.D. Low-dose hypersensitivity in Chinese hamster v79 cells targeted with counted protons using a charged-particle microbeam. Radiat. Res. 156 5 (2001) 526-534
9. Schettino G., Folkard M., Prise K.M., Vojnovic B., Held K.D., and Michael B.D. Low-dose studies of bystander cell killing with targeted soft X rays. Radiat. Res. 160 5 (2003) 505-511
10. Schettino G., Folkard M., Michael B.D., and Prise K.M. Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c-k X rays. Radiat. Res. 163 3 (2005) 332-336
11. Seymour C.B., and Mothersill C. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153 5 (2000) 508-511
12. Steel G. Basic Clinical Radiobiology. third ed. (2002), Hodder Arnold, Paris