Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 1, 2009, Pages 20-28

  South, Samantha M ^a   Edwards, Stephen R ^a   Smith, Maree T ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antinociception; Hot plate; Morphine; Morphine 3 glucuronide; Rat; Serum concentration; Sex differences; Tail flick

Indexed keywords

DRUG METABOLITE; MORPHINE; MORPHINE 3 GLUCURONIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG HALF LIFE; ELECTROCHEMICAL DETECTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT PLATE TEST; MALE; NONHUMAN; RAT; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; TAIL FLICK TEST;

ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRUS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MORPHINE; PAIN; PAIN MEASUREMENT; RATS; SEX CHARACTERISTICS; TESTOSTERONE;

EID: 58549112629     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05019.x     Document Type: Article

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