From molecular shape to potent bioactive agents I: Bioisosteric replacement of molecular fragments

ChemMedChem

Volumn 4, Issue 1, 2009, Pages 41-44

  EwgenijProschak, ^a   Zettl, Heiko ^a   Tanrikulu, Yusuf ^a   Weisel, Martin ^a   Kriegl, Jan M ^b   Rau, Oliver ^a   Schubert Zsilavecz, Manfred ^a   Schneider, Gisbert ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Liff/ZAFES ^*  (Germany)

Author keywords

Bioisosters; Molecular modeling; PPAR agonists; Scaffold hopping; Virtual screening

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

ANIMAL CELL; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DYSLIPIDEMIA; MACROMOLECULE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; COS CELLS; DRUG DESIGN; INHIBITORY CONCENTRATION 50; PPAR ALPHA; PPAR GAMMA; PROPIONIC ACIDS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58549110666     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800313     Document Type: Article

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