Coprecipitation of pharmaceutical actives and their structurally related additives by the RESS process

Powder Technology

Volumn 189, Issue 3, 2009, Pages 444-453

  Vemavarapu, Chandra ^a,b   Mollan, Matthew J ^b   Needham, Thomas E ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b PFIZER INC   (United States)

Author keywords

Coprecipitation; Crystal doping; Rapid expansion; RESS

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENT (API); COMPETING MECHANISMS; CRYSTAL DOPING; CRYSTALLINITY; DRUG DISCOVERIES; EUTECTIC FORMATION; HABIT MODIFICATION; HYDRATE FORMATION; PARTICLE SIZE REDUCTION; RAPID CRYSTALLIZATION; RAPID EXPANSION; RESS; RESS PROCESS; SOLUBILITY ENHANCEMENTS; SUPER-CRITICAL; SUPERCRITICAL SOLUTIONS;

ADDITIVES; EFFLUENT TREATMENT; ELECTROMAGNETIC WAVE EMISSION; HYDRATES; INDUSTRIAL WASTE TREATMENT; MECHANICAL PROPERTIES; MIXTURES; PRECIPITATION (CHEMICAL); SOLUBILITY; SUPERCRITICAL FLUIDS; TERNARY SYSTEMS;

COPRECIPITATION;

ACTIVE PHARMACEUTICAL INGREDIENT; DRUG; DRUG ADDITIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CHEMICAL MODIFICATION; CRYSTAL DOPING; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISPERSION; DRUG DESIGN; DRUG MIXTURE; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MECHANICS; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; RAPID EXPANSION OF SUPERCRITICAL SOLUTION; REDUCTION; SOLUBILITY; SUPERCRITICAL FLUID; SUPERCRITICAL FLUID EXTRACTION; SYNTHESIS;

EID: 58549100457     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.07.005     Document Type: Article

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