-
1
-
-
0025980747
-
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
-
Bartlett R.R., Dimitrijevic M., Mattar T., Zielinski T., Germann T., Rude E., Thoenes G.H., Kuchle C.C., Schorlemmer H.U., Bremer E., et al. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 32 (1991) 10-21
-
(1991)
Agents Actions
, vol.32
, pp. 10-21
-
-
Bartlett, R.R.1
Dimitrijevic, M.2
Mattar, T.3
Zielinski, T.4
Germann, T.5
Rude, E.6
Thoenes, G.H.7
Kuchle, C.C.8
Schorlemmer, H.U.9
Bremer, E.10
-
2
-
-
0033614830
-
Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors. NHLBI post coronary artery bypass graft clinical trial. Post CABG Trial Investigators
-
Campeau L., Hunninghake D.B., Knatterud G.L., White C.W., Domanski M., Forman S.A., Forrester J.S., Geller N.L., Gobel F.L., Herd J.A., Hoogwerf B.J., and Rosenberg Y. Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors. NHLBI post coronary artery bypass graft clinical trial. Post CABG Trial Investigators. Circulation 99 (1999) 3241-3247
-
(1999)
Circulation
, vol.99
, pp. 3241-3247
-
-
Campeau, L.1
Hunninghake, D.B.2
Knatterud, G.L.3
White, C.W.4
Domanski, M.5
Forman, S.A.6
Forrester, J.S.7
Geller, N.L.8
Gobel, F.L.9
Herd, J.A.10
Hoogwerf, B.J.11
Rosenberg, Y.12
-
3
-
-
0028985102
-
The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism
-
Cherwinski H.M., McCarley D., Schatzman R., Devens B., and Ransom J.T. The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism. J. Pharmacol. Exp. Ther. 272 (1995) 460-468
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.272
, pp. 460-468
-
-
Cherwinski, H.M.1
McCarley, D.2
Schatzman, R.3
Devens, B.4
Ransom, J.T.5
-
4
-
-
0019964891
-
A platelet-inhibitor-drug trial in coronary-artery bypass operations: benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency
-
Chesebro J.H., Clements I.P., Fuster V., Elveback L.R., Smith H.C., Bardsley W.T., Frye R.L., Holmes Jr. D.R., Vlietstra R.E., Pluth J.R., Wallace R.B., Puga F.J., Orszulak T.A., Piehler J.M., Schaff H.V., and Danielson G.K. A platelet-inhibitor-drug trial in coronary-artery bypass operations: benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency. N. Engl. J. Med. 307 (1982) 73-78
-
(1982)
N. Engl. J. Med.
, vol.307
, pp. 73-78
-
-
Chesebro, J.H.1
Clements, I.P.2
Fuster, V.3
Elveback, L.R.4
Smith, H.C.5
Bardsley, W.T.6
Frye, R.L.7
Holmes Jr., D.R.8
Vlietstra, R.E.9
Pluth, J.R.10
Wallace, R.B.11
Puga, F.J.12
Orszulak, T.A.13
Piehler, J.M.14
Schaff, H.V.15
Danielson, G.K.16
-
5
-
-
0036845236
-
Genetic interventions for vein bypass graft disease: a review
-
Conte M.S., Mann M.J., Simosa H.F., Rhynhart K.K., and Mulligan R.C. Genetic interventions for vein bypass graft disease: a review. J. Vasc. Surg. 36 (2002) 1040-1052
-
(2002)
J. Vasc. Surg.
, vol.36
, pp. 1040-1052
-
-
Conte, M.S.1
Mann, M.J.2
Simosa, H.F.3
Rhynhart, K.K.4
Mulligan, R.C.5
-
6
-
-
20344390044
-
Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats
-
Crews G.M., Erickson L., Pan F., Fisniku O., Jang M.S., Wynn C., Benediktsson H., Kobayashi M., and Jiang H. Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats. Transplant. Proc. 37 (2005) 1926-1928
-
(2005)
Transplant. Proc.
, vol.37
, pp. 1926-1928
-
-
Crews, G.M.1
Erickson, L.2
Pan, F.3
Fisniku, O.4
Jang, M.S.5
Wynn, C.6
Benediktsson, H.7
Kobayashi, M.8
Jiang, H.9
-
7
-
-
0033397932
-
The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine
-
Czech J., Kurrle R., and Schorlemmer H.U. The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine. Inflamm. Res. 48 Suppl 2 (1999) S128-129
-
(1999)
Inflamm. Res.
, vol.48
, Issue.SUPPL. 2
-
-
Czech, J.1
Kurrle, R.2
Schorlemmer, H.U.3
-
8
-
-
41149146661
-
Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778
-
Deuse T., Hoyt G., Koyanagi T., Robbins R.C., and Schrepfer S. Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778. Transplantation 85 (2008) 870-877
-
(2008)
Transplantation
, vol.85
, pp. 870-877
-
-
Deuse, T.1
Hoyt, G.2
Koyanagi, T.3
Robbins, R.C.4
Schrepfer, S.5
-
9
-
-
3142668958
-
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies
-
Deuse T., Schrepfer S., Schafer H., Koch-Nolte F., Schwedhelm E., Boger R.H., and Reichenspurner H. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 78 (2004) 71-77
-
(2004)
Transplantation
, vol.78
, pp. 71-77
-
-
Deuse, T.1
Schrepfer, S.2
Schafer, H.3
Koch-Nolte, F.4
Schwedhelm, E.5
Boger, R.H.6
Reichenspurner, H.7
-
10
-
-
11844269965
-
Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778
-
Evers D.L., Wang X., Huong S.M., Andreoni K.A., and Huang E.S. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. Antiviral. Res. 65 (2005) 1-12
-
(2005)
Antiviral. Res.
, vol.65
, pp. 1-12
-
-
Evers, D.L.1
Wang, X.2
Huong, S.M.3
Andreoni, K.A.4
Huang, E.S.5
-
11
-
-
0037195055
-
Oral everolimus inhibits in-stent neointimal growth
-
Farb A., John M., Acampado E., Kolodgie F.D., Prescott M.F., and Virmani R. Oral everolimus inhibits in-stent neointimal growth. Circulation 106 (2002) 2379-2384
-
(2002)
Circulation
, vol.106
, pp. 2379-2384
-
-
Farb, A.1
John, M.2
Acampado, E.3
Kolodgie, F.D.4
Prescott, M.F.5
Virmani, R.6
-
12
-
-
20144389837
-
Treatment of saphenous vein graft lesions with drug-eluting stents: immediate and midterm outcome
-
Ge L., Iakovou I., Sangiorgi G.M., Chieffo A., Melzi G., Cosgrave J., Montorfano M., Michev I., Airoldi F., Carlino M., Corvaja N., and Colombo A. Treatment of saphenous vein graft lesions with drug-eluting stents: immediate and midterm outcome. J. Am. Coll. Cardiol. 45 (2005) 989-994
-
(2005)
J. Am. Coll. Cardiol.
, vol.45
, pp. 989-994
-
-
Ge, L.1
Iakovou, I.2
Sangiorgi, G.M.3
Chieffo, A.4
Melzi, G.5
Cosgrave, J.6
Montorfano, M.7
Michev, I.8
Airoldi, F.9
Carlino, M.10
Corvaja, N.11
Colombo, A.12
-
13
-
-
4143148546
-
Oral rapamycin to prevent human coronary stent restenosis: a pilot study
-
Guarda E., Marchant E., Fajuri A., Martinez A., Moran S., Mendez M., Uriarte P., Valenzuela E., and Lazen R. Oral rapamycin to prevent human coronary stent restenosis: a pilot study. Am. Heart. J. 148 (2004) e9
-
(2004)
Am. Heart. J.
, vol.148
-
-
Guarda, E.1
Marchant, E.2
Fajuri, A.3
Martinez, A.4
Moran, S.5
Mendez, M.6
Uriarte, P.7
Valenzuela, E.8
Lazen, R.9
-
14
-
-
4143135132
-
Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial
-
Hausleiter J., Kastrati A., Mehilli J., Vogeser M., Zohlnhofer D., Schuhlen H., Goos C., Pache J., Dotzer F., Pogatsa-Murray G., Dirschinger J., Heemann U., and Schomig A. Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial. Circulation 110 (2004) 790-795
-
(2004)
Circulation
, vol.110
, pp. 790-795
-
-
Hausleiter, J.1
Kastrati, A.2
Mehilli, J.3
Vogeser, M.4
Zohlnhofer, D.5
Schuhlen, H.6
Goos, C.7
Pache, J.8
Dotzer, F.9
Pogatsa-Murray, G.10
Dirschinger, J.11
Heemann, U.12
Schomig, A.13
-
15
-
-
0028027390
-
Vein graft intimal hyperplasia: leukocytes and cytokine gene expression
-
discussion 470-461
-
Hoch J.R., Stark V.K., Hullett D.A., and Turnipseed W.D. Vein graft intimal hyperplasia: leukocytes and cytokine gene expression. Surgery 116 (1994) 463-470 discussion 470-461
-
(1994)
Surgery
, vol.116
, pp. 463-470
-
-
Hoch, J.R.1
Stark, V.K.2
Hullett, D.A.3
Turnipseed, W.D.4
-
16
-
-
22244439912
-
2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis
-
Jahnke T., Schafer F.K., Bolte H., Rector L., Schafer P.J., Brossmann J., Fandrich F., Hedderich J., Heller M., and Muller-Hulsbeck S. 2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis. J. Vasc. Interv. Radiol. 16 (2005) 903-910
-
(2005)
J. Vasc. Interv. Radiol.
, vol.16
, pp. 903-910
-
-
Jahnke, T.1
Schafer, F.K.2
Bolte, H.3
Rector, L.4
Schafer, P.J.5
Brossmann, J.6
Fandrich, F.7
Hedderich, J.8
Heller, M.9
Muller-Hulsbeck, S.10
-
17
-
-
0021891679
-
Management of end-stage renal disease by transplantation: the use and limitations of cyclosporine
-
Kahan B.D., Van Buren C.T., Weinman E.J., Sandler C.M., Maddox A.M., and Van Horn G. Management of end-stage renal disease by transplantation: the use and limitations of cyclosporine. Tex. Med. 81 (1985) 32-43
-
(1985)
Tex. Med.
, vol.81
, pp. 32-43
-
-
Kahan, B.D.1
Van Buren, C.T.2
Weinman, E.J.3
Sandler, C.M.4
Maddox, A.M.5
Van Horn, G.6
-
18
-
-
0029964158
-
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
-
Linke S.P., Clarkin K.C., Di Leonardo A., Tsou A., and Wahl G.M. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10 (1996) 934-947
-
(1996)
Genes Dev.
, vol.10
, pp. 934-947
-
-
Linke, S.P.1
Clarkin, K.C.2
Di Leonardo, A.3
Tsou, A.4
Wahl, G.M.5
-
19
-
-
0033573158
-
Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases
-
Mangold U., Dax C.I., Saar K., Schwab W., Kirschbaum B., and Mullner S. Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur. J. Biochem. 266 (1999) 1184-1191
-
(1999)
Eur. J. Biochem.
, vol.266
, pp. 1184-1191
-
-
Mangold, U.1
Dax, C.I.2
Saar, K.3
Schwab, W.4
Kirschbaum, B.5
Mullner, S.6
-
20
-
-
0028895216
-
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine
-
Nair R.V., Cao W., and Morris R.E. Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunol. Lett. 47 (1995) 171-174
-
(1995)
Immunol. Lett.
, vol.47
, pp. 171-174
-
-
Nair, R.V.1
Cao, W.2
Morris, R.E.3
-
21
-
-
0026333037
-
Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts
-
O'Donohoe M.K., Schwartz L.B., Radic Z.S., Mikat E.M., McCann R.L., and Hagen P.O. Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts. Ann. Surg. 214 (1991) 727-732
-
(1991)
Ann. Surg.
, vol.214
, pp. 727-732
-
-
O'Donohoe, M.K.1
Schwartz, L.B.2
Radic, Z.S.3
Mikat, E.M.4
McCann, R.L.5
Hagen, P.O.6
-
22
-
-
0033135670
-
Production and inhibition of the gelatinolytic matrix metalloproteinases in a human model of vein graft stenosis
-
Porter K.E., Thompson M.M., Loftus I.M., McDermott E., Jones L., Crowther M., Bell P.R., and London N.J. Production and inhibition of the gelatinolytic matrix metalloproteinases in a human model of vein graft stenosis. Eur. J. Vasc. Endovasc. Surg. 17 (1999) 404-412
-
(1999)
Eur. J. Vasc. Endovasc. Surg.
, vol.17
, pp. 404-412
-
-
Porter, K.E.1
Thompson, M.M.2
Loftus, I.M.3
McDermott, E.4
Jones, L.5
Crowther, M.6
Bell, P.R.7
London, N.J.8
-
23
-
-
0042467489
-
Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection
-
discussion 471-453
-
Savikko J., Von Willebrand E., and Hayry P. Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Transplantation 76 (2003) 455-458 discussion 471-453
-
(2003)
Transplantation
, vol.76
, pp. 455-458
-
-
Savikko, J.1
Von Willebrand, E.2
Hayry, P.3
-
24
-
-
33847742394
-
Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
-
Schrepfer S., Deuse T., Sultan K.R., Haddad M., Boger R., Munzel T., Schafer H., Pelletier M.P., Robbins R.C., and Reichenspurner H. Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?. Cardiology 108 (2007) 128-137
-
(2007)
Cardiology
, vol.108
, pp. 128-137
-
-
Schrepfer, S.1
Deuse, T.2
Sultan, K.R.3
Haddad, M.4
Boger, R.5
Munzel, T.6
Schafer, H.7
Pelletier, M.P.8
Robbins, R.C.9
Reichenspurner, H.10
-
25
-
-
0032831242
-
Systematic review of randomized controlled trials of aspirin and oral anticoagulants in the prevention of graft occlusion and ischemic events after infrainguinal bypass surgery
-
Tangelder M.J., Lawson J.A., Algra A., and Eikelboom B.C. Systematic review of randomized controlled trials of aspirin and oral anticoagulants in the prevention of graft occlusion and ischemic events after infrainguinal bypass surgery. J. Vasc. Surg. 30 (1999) 701-709
-
(1999)
J. Vasc. Surg.
, vol.30
, pp. 701-709
-
-
Tangelder, M.J.1
Lawson, J.A.2
Algra, A.3
Eikelboom, B.C.4
-
26
-
-
1942509402
-
Dose-dependent inhibition of myointimal hyperplasia by orally administered rapamycin
-
Uchimura N., Perera G.B., Fujitani R.M., Tobis J.M., Ishimaru S., Wilson S.E., and Gordon I.L. Dose-dependent inhibition of myointimal hyperplasia by orally administered rapamycin. Ann. Vasc. Surg. 18 (2004) 172-177
-
(2004)
Ann. Vasc. Surg.
, vol.18
, pp. 172-177
-
-
Uchimura, N.1
Perera, G.B.2
Fujitani, R.M.3
Tobis, J.M.4
Ishimaru, S.5
Wilson, S.E.6
Gordon, I.L.7
-
27
-
-
3142734960
-
The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients
-
Vanrenterghem Y., van Hooff J.P., Klinger M., Wlodarczyk Z., Squifflet J.P., Mourad G., Neuhaus P., Jurewicz A., Rostaing L., Charpentier B., Paczek L., Kreis H., Chang R., Paul L.C., Grinyo J.M., and Short C. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. Transplantation 78 (2004) 9-14
-
(2004)
Transplantation
, vol.78
, pp. 9-14
-
-
Vanrenterghem, Y.1
van Hooff, J.P.2
Klinger, M.3
Wlodarczyk, Z.4
Squifflet, J.P.5
Mourad, G.6
Neuhaus, P.7
Jurewicz, A.8
Rostaing, L.9
Charpentier, B.10
Paczek, L.11
Kreis, H.12
Chang, R.13
Paul, L.C.14
Grinyo, J.M.15
Short, C.16
-
28
-
-
23844482954
-
Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization
-
Windecker S., Remondino A., Eberli F.R., Juni P., Raber L., Wenaweser P., Togni M., Billinger M., Tuller D., Seiler C., Roffi M., Corti R., Sutsch G., Maier W., Luscher T., Hess O.M., Egger M., and Meier B. Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization. N. Engl. J. Med. 353 (2005) 653-662
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 653-662
-
-
Windecker, S.1
Remondino, A.2
Eberli, F.R.3
Juni, P.4
Raber, L.5
Wenaweser, P.6
Togni, M.7
Billinger, M.8
Tuller, D.9
Seiler, C.10
Roffi, M.11
Corti, R.12
Sutsch, G.13
Maier, W.14
Luscher, T.15
Hess, O.M.16
Egger, M.17
Meier, B.18
-
29
-
-
12344318112
-
Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats
-
Zeng H., Waldman W.J., Yin D.P., Knight D.A., Shen J., Ma L., Meister G.T., Chong A.S., and Williams J.W. Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. Transplantation 79 (2005) 17-22
-
(2005)
Transplantation
, vol.79
, pp. 17-22
-
-
Zeng, H.1
Waldman, W.J.2
Yin, D.P.3
Knight, D.A.4
Shen, J.5
Ma, L.6
Meister, G.T.7
Chong, A.S.8
Williams, J.W.9
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