Influenza A viruses with truncated NS1 as modified live virus vaccines: Pilot studies of safety and efficacy in horses

Equine Veterinary Journal

Volumn 41, Issue 1, 2009, Pages 87-92

  Chambers, T M ^a   Quinlivan, M ^b,c   Sturgill, T ^a   Cullinane, A ^b   Horohov, D W ^a   Zamarin, D ^d   Arkins, S ^b   Garci Asastre A ^d,e   Palese, P ^d,e  

^a UNIVERSITY OF KENTUCKY   (United States)

^b IRISH EQUINE CENTRE   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

^d Department of Microbiology ^*

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokine; Equine influenza; Horse; Intranasal; NS 1; Reverse genetics; Vaccine

Indexed keywords

CYTOKINE; INFLUENZA VACCINE; INS1 PROTEIN, INFLUENZA VIRUS; LIVE VACCINE; VIRUS ANTIBODY; VIRUS PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; BLOOD; GENETIC RECOMBINATION; GENETICS; HORSE; HORSE DISEASE; IMMUNOLOGY; INFLUENZA VIRUS A H3N8; INTRANASAL DRUG ADMINISTRATION; NEBULIZER; ORTHOMYXOVIRUS INFECTION; PILOT STUDY; SAFETY; TIME; TREATMENT OUTCOME; VACCINATION; VIROLOGY; VIRUS SHEDDING;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; CYTOKINES; HORSE DISEASES; HORSES; INFLUENZA A VIRUS, H3N8 SUBTYPE; INFLUENZA VACCINES; NEBULIZERS AND VAPORIZERS; ORTHOMYXOVIRIDAE INFECTIONS; PILOT PROJECTS; RECOMBINATION, GENETIC; SAFETY; TIME FACTORS; TREATMENT OUTCOME; VACCINATION; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS SHEDDING;

ANIMALIA; EQUIDAE; EQUINE INFLUENZA VIRUS; INFLUENZA A VIRUS; INFLUENZAVIRUS A; ORTHOMYXOVIRIDAE;

EID: 58549085205     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516408X371937     Document Type: Article

References (39)

1. Baskin, C.R., Bielefeldt-Ohmann, H., Garcia-Sastre, A., Tumpey, T.M., van Hoeven, N., Carter, V.S., Thomas, M.J., Proll, S., Solorzano, A., Billharz, R., Fornek, J.L., Thomas, S., Chen, C.H., Clark, E.A., Murali-Krishna, K. and Katze, M.G. (2007) Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J. Virol. 81, 11817-11827.
2. Chambers, T.M., Holland, R.E., Tudor, L.R., Townsend, H.G., Cook, A., Bogdan, J., Lunn, D.P., Hussey, S., Whitaker-Dowling, P., Youngner, J.S., Sebring, R.W., Penner, S.J. and Stiegler, G.L. (2001) A new modified live equine influenza virus vaccine: phenotypic stability, restricted spread and efficacy against heterologous virus challenge. Equine vet. J. 33, 630-636.
3. Daly, J.M., Yates, P.J., Newton, J.R., Park, A., Henley, W., Wood, J.L., Davis-Poynter, N. and Mumford, J.A. (2004) Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines. Vaccine 22, 4101-4109.
4. Donelan, N.R., Basler, C.F. and Garcia-Sastre, A. (2003) A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J. Virol. 77, 13257-13266.
5. Edwards, K.M., Dupont, W.D., Westrich, M.K., Plummer, W.D., Jr., Palmer, P.S. and Wright, P.F. (1994) A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. J. Infect. Dis. 169, 68-76.
6. Egorov, A., Brandt, S., Sereinig, S., Romanova, J., Ferko, B., Katinger, D., Grassauer, G., Alexandrova, G., Katinger, H. and Muster, T. (1998) Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J. Virol. 72, 6437-6441.
7. Ferko, B., Kittel, C., Romanova, J., Sereinig, S., Katinger, H. and Egorov, A. (2006) Live attenuated influenza virus expressing human interleukin-2 reveals increased immunogenic potential in young and aged hosts. J. Virol. 80, 11621-11627.
8. Fodor, E., Devenish, L., Engelhardt, O.G., Palese, P., Brownlee, G.G. and Garcia-Sastre, A. (1999) Rescue of influenza A virus from recombinant DNA. J. Virol. 73, 9679-9682.
9. Garcia-Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D.E., Durbin, J.E., Palese, P. and Muster, T. (1998) Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virol. 252, 324-330.
10. Gorse, G.J., Campbell, M.J., Otto, E.E., Powers, D.C., Chambers, G.W. and Newman, F.K. (1995) Increased anti-influenza A virus cytotoxic T cell activity following vaccination of the chronically ill elderly with live attenuated or inactivated influenza virus vaccine. J. Infect. Dis. 172, 1-10.
11. Hannant, D. and Mumford, J.A. (1989) Cell mediated immune responses in ponies following infection with equine influenza virus (H3N8): the influence of induction culture conditions on the properties of cytotoxic effector cells. Vet. Immunol. Immunopathol. 21, 327-337.
12. Hannant, D., Mumford, J.A. and Jessett, D.M. (1988) Duration of circulating antibody and immunity following infection with equine influenza virus. Vet. Rec. 122, 125-128.
13. Hayden, F.G., Fritz, R.S., Lobo, M.C., Alvord, W.G., Strober, W. and Straus, E. (1998) Local and systemic cytokine responses during experimental human influenza A virus infection. J. clin. Invest. 101, 643-649.
14. Kochs, G., Garcia-Sastre, A. and Martinez-Sobrido, L. (2007) Multiple antiinterferon actions of the influenza A virus NS1 protein. J. Virol. 81, 7011-7021.
15. Lunn, D.P., Soboll, G., Schram, B.R., Quass, J., McGregor, M.W., Drape, R.J., Macklin, M.D., McCabe, D.E., Swain, W.F. and Olsen, C.W. (1999) Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine 17, 2245-2258.
16. Morley, P.S., Hanson, L.K., Bogdan, J.R., Townsend, H.G., Appleton, J.A. and Haines, D.M. (1995) The relationship between single radial hemolysis, hemagglutination inhibition, and virus neutralization assays used to detect antibodies specific for equine influenza viruses. Vet. Microbiol. 45, 81-92.
17. Mumford, E.L., Traub-Dargatz, J.L., Salman, M.D., Collins, J.K., Getzy, D.M. and Carman, J. (1998) Monitoring and detection of acute viral respiratory tract disease in horses. J. Am. vet. med. Ass. 213, 385-390.
18. Mumford, J.A., Hannant, D. and Jessett, D.M. (1990) Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine vet. J. 22, 93-98.
19. Neumann, G., Watanabe, T., Ito, H., Watanabe, S., Goto, H., Gao, P., Hughes, M., Perez, D.R., Donis, R., Hoffmann, E., Hobom, G. and Kawaoka, Y. (1999) Generation of influenza A viruses entirely from cloned cDNAs. Proc. Natl. Acad. Sci. USA 96, 9345-9350.
20. Newton, J.R., Townsend, H.G., Wood, J.L., Sinclair, R., Hannant, D. and Mumford, J.A. (2000) Immunity to equine influenza: relationship of vaccine-induced antibody in young Thoroughbred racehorses to protection against field infection with influenza A/equine-2 viruses (H3N8). Equine vet. J. 32, 65-74.
21. Paillot, R., Grimmett, H., Elton, D. and Daly, J.M. (2008) Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host. Vet. Res. 39, 21.
22. Paillot, R., Hannant, D., Kydd, J.H. and Daly, J.M. (2006a) Vaccination against equine influenza: Quid novi? Vaccine, 24, 4047-4061.
23. Paillot, R., Kydd, J.H., Sindle, T., Hannant, D., Edlund Toulemonde, C., Audonnet, J.C., Minke, J.M. and Daly, J.M. (2006b) Antibody and IFN-gamma responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus. Vet. Immunol. Immunopathol. 112, 225-233.
24. Palese, P. and Garcia-Sastre, A. (2002) Influenza vaccines: present and future. J. Clin. Invest. 110, 9-13.
25. Palese, P. and Shaw, M.L. (2007) Orthomyxoviridae: the viruses and their replication. In: Fields' Virology, 5th edn., Eds: B.N. Fields, D.M. Knipe and P.M. Howley, Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia. pp 1647-1690.
26. Park, A.W., Wood, J.L., Newton, J.R., Daly, J., Mumford, J.A. and Grenfell, B.T. (2003) Optimising vaccination strategies in equine influenza. Vaccine 21, 2862-2870.
27. Quinlivan, M., Zamarin, D., Garcia-Sastre, A., Cullinane, A., Chambers, T. and Palese, P. (2005) Attenuation of equine influenza viruses through truncations of the NS1 protein. J. Virol. 79, 8431-8439.
28. Quinlivan, M., Nelly, M., Prendergast, M., Breathnach, C., Horohov, D., Arkins, S., Chiang, Y.W., Chu, H.J., Ng, T. and Cullinane, A. (2007) Pro-inflammatory and antiviral cytokine expression in vaccinated and unvaccinated horses exposed to equine influenza virus. Vaccine 25, 7056-7064.
29. Renegar, K.B. and Small, P.A., Jr. (1991) Passive transfer of local immunity to influenza virus infection by IgA antibody. J. Immunol. 146, 1972-1978.
30. Richt, J.A., Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Loiacono, C.M., Janke, B.H., Wu, W.H., Yoon, K.J., Webby, R.J., Solorzano, A. and Garcia-Sastre, A. (2006) Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J. Virol. 80, 11009-11018.
31. Soboll, G., Nelson, K.M., Leuthner, E.S., Clark, R.J., Drape, R., Macklin, M.D., Swain, W.F., Olsen, C.W. and Lunn, D.P. (2003a) Mucosal co-administration of cholera toxin and influenza virus hemagglutinin-DNA in ponies generates a local IgA response. Vaccine 21, 3081-3092.
32. Soboll, G., Horohov, D.W., Aldridge, B.M., Olsen, C.W., McGregor, M.W., Drape, R.J., Macklin, M.D., Swain, W.F. and Lunn, D.P. (2003b) Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination. Vet. Immunol. Immunopathol. 94, 47-62.
33. Solorzano, A., Webby, R.J., Lager, K.M., Janke, B.H., Garcia-Sastre, A. and Richt, J.A. (2005) Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J. Virol. 79, 7535-7543.
34. Talon, J., Salvatore, M., O Neill, R.E., Nakaya, Y., Zheng, H., Muster, T., García-Sastre, A. and Palese, P. (2000) Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach. Proc. Natl. Acad. Sci. USA. 97, 4309-4314.
35. Tamura, S., Funato, H., Hirabayashi, Y., Kikuta, K., Suzuki, Y., Nagamine, T., Aizawa, C., Nakagawa, M. and Kurata, T. (1990) Functional role of respiratory tract haemagglutinin-specific IgA antibodies in protection against influenza. Vaccine 8, 479-485.
36. Townsend, H.G., Penner, S.J., Watts, T.C., Cook, A., Bogdan, J., Haines, D.M., Griffin, S., Chambers, T., Holland, R.E., Whitaker-Dowling, P., Youngner, J.S. and Sebring, R.W. (2001) Efficacy of a cold-adapted, intranasal, equine influenza vaccine: challenge trials. Equine vet. J. 33, 637-643.
37. van Reeth, K., Nauwynck, H. and Pensaert, M. (1998) Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: a possible model for humans? J. Infect. Dis. 177, 1076-1079.
38. Wattrang, E., Jessett, D.M., Yates, P., Fuxler, L. and Hannant, D. (2003) Experimental infection of ponies with equine influenza A2 (H3N8) virus strains of different pathogenicity elicits varying interferon and interleukin-6 responses. Viral. Immunol. 16, 57-67.
39. Wilson, W.D., Mihalyi, J.E., Hussey, S. and Lunn, D.P. (2001) Passive transfer of maternal immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination. Equine vet. J. 33, 644-650.