Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition

Neuropharmacology

Volumn 56, Issue 2, 2009, Pages 399-404

  Wei, Hua ^a   Hill, Erik R ^a   Gu, Howard H ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressants; Cocaine; Dopamine transporter; Norepinephrine transporter; Random mutagenesis

Indexed keywords

AMPHETAMINE; COCAINE; DESIPRAMINE; METHAMPHETAMINE; METHYLPHENIDATE; MUTANT PROTEIN; NORADRENALIN TRANSPORTER;

ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG INHIBITION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BIOTINYLATION; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING; TRANSFECTION; TRITIUM;

EID: 58549083337     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.09.008     Document Type: Article

References (17)

1. Amara S.G., and Kuhar M.J. Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 16 (1993) 73-93
2. Chen R., Han D.D., and Gu H.H. A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate. J. Neurochem. 94 (2005) 352-359
3. Chen R., Tilley M.R., Wei H., Zhou F., Zhou F.M., Ching S., Quan N., Stephens R.L., Hill E.R., Nottoli T., Han D.D., and Gu H.H. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 9333-9338
4. Dipace C., Sung U., Binda F., Blakely R.D., and Galli A. Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Mol. Pharmacol. 71 (2007) 230-239
5. Gu H.H., Ahn J., Caplan M.J., Blakely R.D., Levey A.I., and Rudnick G. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J. Biol. Chem. 271 (1996) 18100-18106
6. Gu H.H., Wu X., and Han D.D. Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding. Biochem. Biophys. Res. Commun. 343 (2006) 1179-1185
7. Han D.D., and Gu H.H. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol. 6 (2006) 6
8. Kuhar M.J., Ritz M.C., and Boja J.W. The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci. 14 (1991) 299-302
9. Lin Z., and Uhl G.R. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Mol. Pharmacol. 61 (2002) 885-891
10. Rocha B.A., Fumagalli F., Gainetdinov R.R., Jones S.R., Ator R., Giros B., Miller G.W., and Caron M.G. Cocaine self-administration in dopamine-transporter knockout mice [see comments] [published erratum appears in Nat. Neurosci. 1998 Aug;1(4):330]. Nat. Neurosci. 1 (1998) 132-137
11. Rothman R.B., and Baumann M.H. Monoamine transporters and psychostimulant drugs. Eur. J. Pharmacol. 479 (2003) 23-40
12. Sora I., Wichems C., Takahashi N., Li X.F., Zeng Z., Revay R., Lesch K.P., Murphy D.L., and Uhl G.R. Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 7699-7704
13. Ventura R., Morrone C., and Puglisi-Allegra S. Prefrontal/accumbal catecholamine system determines motivational salience attribution to both reward- and aversion-related stimuli. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 5181-5186
14. Wise R.A., and Bozarth M.A. A psychomotor stimulant theory of addiction. Psychol. Rev. 94 (1987) 469-492
15. Wu X., and Gu H.H. Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Mol. Pharmacol. 63 (2003) 653-658
16. Xu F., Gainetdinov R.R., Wetsel W.C., Jones S.R., Bohn L.M., Miller G.W., Wang Y.M., and Caron M.G. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat. Neurosci. 3 (2000) 465-471
17. +/Cl-dependent neurotransmitter transporters. Nature 437 (2005) 215-223