Dual radiotracer analysis of cholinergic neuronal changes in prediabetic mouse pancreas

Diabetes Technology and Therapeutics

Volumn 11, Issue 2, 2009, Pages 107-111

  Clark, Paige B ^a   Plaza, Michael J ^a   Kraas, Jonathan ^a   Burbank, Nicole ^a   Elster II, Allen W ^a   Garg, Pradeep ^a   Garg, Sudha ^a   Gage, H Donald ^a   Calles Escandon, Jorge ^a   Wagner, Janice D ^a   Morton, Kathryn ^b  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUOROBENZYLTROZAMICOL F 18; GLUCOSE; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DIET RESTRICTION; EX VIVO STUDY; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL;

ANIMALS; FLUORINE RADIOISOTOPES; FLUOROBENZENES; INSULIN-SECRETING CELLS; MICE; PANCREAS; PARASYMPATHOLYTICS; PIPERIDINES; PREDIABETIC STATE; TRITIUM;

EID: 58449128490     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2008.0024     Document Type: Article

References (24)

1. Gautam D, Han S-J, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J: A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 2006;3:449-461.
2. Kiba T: Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis. Pancreas 2004;29:e51-e58.
3. Brunicardi FC, Shavelle DM, Andersen DK: Neural regulation of the endocrine pancreas. Int J Pancreatol 1995;18:177-195.
4. Efange SMN, Garland EM, Staley JK, Khare AB, Mash DC: Vesicular acetylcholine transporter density and Alzheimer's disease. Neurobiol Aging 1997;18:407-413.
5. Efange SMN: In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter. FASEB J 2000;14:2401-2413.
6. Gage HD, Gage JC, Chiari A, Xu Z-M, Mach RH, Efange SMN, Ehrenkaufer RLE, Eisenach JC: In vivo imaging of the spinal cord cholinergic system with PET. J Comput Assist Tomogr 1999;23:25-33.
7. 18F](+)-4-fluorobenzyltrozamicol and PET in the rhesus monkey brain. J Nucl Med 2000;41:2069-2076.
8. 18F](+)-4-fluorobenzyltrozamicol: in vitro binding studies and positron emission tomography studies in nonhuman primates. Synapse 1997;25:368-380.
9. Voytko ML, Mach RH, Gage HD, Ehrenkaufer RLE, Efange SMN, Tobin JR: Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography. Synapse 2001;39:95-100.
10. Clark PB, Gage HD, Brown-Proctor C, Buchheimer N, Calles-Escandon J, Mach RH, Morton KA: Neurofunctional imaging of the pancreas utilizing the cholinergic PET radioligand [18F]4-fluorobenzyltrozamicol. Eur J Nucl Med Mol Imaging 2004;31:258-260.
11. 18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy. Endocr Dev 2007;12:55-66.
12. 18F-DOPA) positron emission tomography as a tool to localize an insulinoma or beta-cell hyperplasia in adult patients. J Clin Endocrinol Metab 2007;92:1237-1244.
13. 11C]DTBZ. Nucl Med Biol 2006;33:855-864.
14. Ostenson C-G, Grill V: Evidence that hyperglycemia increases muscarinic binding in pancreatic islets of the rat. Endocrinology 1987;121:1705-1710.
15. 2+ regulation in pancreatic acinar cells from acute streptozotocin-induced diabetic rats. Eur J Pharmacol 1996;298:299-306.
16. Van der Kloot W: Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junction. Prog Neurobiol 2003;71:269-303.
17. Iismaa TP, Kerr EA, Wilson JR, Carpenter L, Sims N, Biden TJ: Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets. Diabetes 2000;49:392-398.
18. Duttaroy A, Zimliki CL, Gautam D, Cui Y, Mears D, Wess J: Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes 2004;53:1714-1720.
19. Van Waarde A, Visser GM, Visser TJ, Bouwer J, Paans AMJ, Vaalburg W: Rodent biodistribution and metabolism of tritiated 4-DAMP, a M3 subtype-selective cholinoceptor ligand. Nucl Med Biol 1994;21:41-47.
20. Eisenbarth GS: Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986;314:1360-1368.
21. 18F]FBT): molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography. Appl Radiat Isot 1994;45:465-472.
22. Gilon P, Henquin J-C: Mechanisms and physiological significance of the cholinergic control of pancreatic beta cell function. Endocr Rev 2001;22:565-604.
23. Ahren B: Autonomic regulation of islet hormone secretion: implications for health and disease. Diabetologia 2000;43:393-410.
24. Godfrey DA, Matschinsky FM: Enzymes of the cholinergic system in islets of Langerhans. J Histochem Cytochem 1975;23:645-651.