Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate

Journal of Pathology

Volumn 217, Issue 1, 2009, Pages 42-53

  Abe, A ^a   Fukui, H ^a   Fujii, S ^a   Kono, T ^a   Mukawa, K ^a   Yoshitake, N ^a   Sekikawa, A ^a   Ichikawa, K ^a   Tomita, S ^a   Yamagishi, H ^a   Imai, Y ^a   Shinoda, M ^a   Ishizaki, H ^b,c   Tanaka Okamoto, M ^b   Kubota, K ^a   Miyoshi, J ^b   Takai, Y ^d,e   Fujimori, T ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c Osaka Medical Center for Cancer and Cardiovascular Diseases ^*  (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CD155; Colitis; Colon cancer; K ras; Necl 5; Proliferation; PVR; TAGE4

Indexed keywords

DEXTRAN SULFATE; DIMETHYLHYDRAZINE; K RAS PROTEIN; KI 67 ANTIGEN; PROTEIN NECL 5; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CODON; COLITIS; COLON CANCER; COLON INJURY; CONTROLLED STUDY; GENE MUTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECTUM INJURY; WILD TYPE;

ANIMALS; ANTIGENS, NEOPLASM; BIRTH WEIGHT; CELL ADHESION MOLECULES; COLITIS, ULCERATIVE; COLON; COLORECTAL NEOPLASMS; DEXTRAN SULFATE; DIMETHYLHYDRAZINES; DISEASE MODELS, ANIMAL; GENES, RAS; GROWTH; INTESTINAL MUCOSA; KI-67 ANTIGEN; MICE; MICE, KNOCKOUT; MUTATION; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58449124887     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2431     Document Type: Article

References (24)

1. Abercrombie M. Contact inhibition and malignancy. Nature 1979;281:259-262.
2. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nature Rev Cancer 2002;2:442-454.
3. Takai Y, Nakanishi H. Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 2003;116:17-27.
4. Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and polarization. Nature Rev Mol Cell Biol 2008;9:603-615.
5. Ikeda W, Kakunaga S, Itoh S, Shingai T, Takekuni K, Satoh K, et al. Tage4/Nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule Nectin-3 and enhances cell migration. JBiol Chem 2003;278:28167-28172.
6. Miyoshi J, Takai Y. Nectin and nectin-like molecules: biology and pathology. Am J Nephrol 2007;27:590-604.
7. Sato T, Irie K, Ooshio T, Ikeda W, Takai Y. Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells 2004;9:791-799.
8. Kakunaga S, Ikeda W, Shingai T, Fujito T, Yamada A, Minami Y, et al. Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/PVR/CD155 through the Ras-Raf-MEK-ERK signalling. JBiol Chem 2004;279:36419-36425.
9. Ikeda W, Kakunaga S, Takekuni K, Shingai T, Satoh K, Mori-moto K, et al. Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, nectin-3-independent manner. JBiol Chem 2004;279:18015-18025.
10. Chadeneau C, LeMoullac B, Denis MG. A novel member of the immunoglobulin gene superfamily expressed in rat carcinoma cell lines. J Biol Chem 1994;269:15601-15605.
11. Chadeneau C, LeCabellec M, LeMoullac B, Meflah K, Denis MG. Overexpression of a novel member of the immunoglobulin superfamily in Min mouse intestinal adenomas. Int J Cancer 1996;68:817-821.
12. Masson D, Jarry A, Baury B, Blanchardie P, Laboisse C, Lusten-berger P, et al. Overexpression of the CD155 gene in human colorectal carcinoma. Gut 2001;49:236-240.
13. Gromeier M, Lachmann S, Rosenfeld MR, Gutin PH, Wimmer E. Intergeneric poliovirus recombinants for the treatment of malignant glioma. Proc Natl Acad Sci U S A 2000;97:6803-6808.
14. Togawa A, Miyoshi J, Ishizaki H, Tanaka M, Takakura A, Nishioka H, et al. Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDI alpha. Oncogene 1999;18:5373-5380.
15. Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000;47:251-255.
16. Fujii S, Fujimori T, Kawamata H, Takeda J, Kitajima K, Omotehara F, et al. Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium. Gut 2004;53:710-716.
17. Zaidi NH, Pretlow TP, O'Riordan MA, Dumenco LL, Allay E, Gerson SL. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K- ras oncogene of mouse colon. Carcinogenesis 1995;16:451-456.
18. Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 2003;94:965-973.
19. Kohno H, Suzuki R, Sugie S, Tanaka T. β -Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci 2005;96:69-76.
20. Kajita M, Ikeda W, Tamaru Y, Takai Y. Regulation of the platelet- derived growth factor-induced Ras signaling by poliovirus receptor Necl-5 and negative growth regulator Sprouty2. Genes Cells 2007;12:345-357.
21. Hirota T, Irie K, Okamoto R, Ikeda W, Takai Y. Transcriptional activation of the mouse Necl-5/Tage4/PVR/CD155 gene by fibroblast growth factor or oncogenic Ras through the Raf-MEK-ERk-AP-1 pathway. Oncogene 2005;24:2229-2235.
22. Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, et al. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. JExp Med 2003;198:557-567.
23. Reymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, et al. DNAM-1 and PVR regulate monocyte migration through endothelial junctions. J Exp Med 2004;199:1331-1341.
24. Morimoto K, Satoh-Yamaguchi K, Hamaguchi A, Inoue Y, TakeuchiM, Okada M, et al. Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lung. Oncogene 2008;27:264-273.