Determination of propylthiouracil in pharmaceutical formulation by high-performance liquid-chromatography with a post-column iodine-azide reaction as a detection system

Archives of Pharmacal Research

Volumn 31, Issue 12, 2008, Pages 1622-1630

  Zakrzewski, Robert ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Drug assay; HPLC; Iodine azide reaction; Propylthiouracil

Indexed keywords

ACETONITRILE; IODINE; PROPYLTHIOURACIL; SODIUM AZIDE; THYROSAN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG DETERMINATION; DRUG FORMULATION; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POSTCOLUMN IODINE AZIDE REACTION; SENSITIVITY AND SPECIFICITY;

ANTIMETABOLITES; AZIDES; CALIBRATION; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; IODINE; PROPYLTHIOURACIL; REFERENCE STANDARDS; TABLETS;

EID: 58449121082     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-2160-8     Document Type: Article

References (17)

1. A. M. Abdul-Fattah H. N. Bhargava 2001 Development and validation of a high-performance liquid chromatographic method for the analysis of propylthiouracil in pharmaceuticals Drug Dev. Ind. Pharm. 27 831 835
2. C. S. Bittencourt A. E. C. S. Azzolini D. A. Ferreira A. I. Assis-Pandochi 2007 Antibody responses in hyperthyroid rats Int. Immunopharmacol. 7 989 993
3. M. M. U. Chowdhury R. Marks 2001 Oral propylthiouracil for the treatment of resistant plaque psoriasis J Dermatolog Treat 12 81 85
4. A. N. Elias R. J. Barr M. K. Rohan K. Dangaran 1995 Effect of orally administered antithyroid thioureylenes on PCNA and P53 expression in psoriatic lesions Int. J Dermatol. 34 280 283
5. N. P. Hadjiangelis T. J. Harkin 2007 Propylthiouracil-related diffuse alveolar hemorrhage with negative serologies and without capillaritis Respir. Med. 101 865 867
6. J. Kurzawa 1985 Determination of micro- and nanogramme amounts of 2-thiouracil and its 6-substituted derivatives by induced iodine-azide reaction Quim. Anal. 4 117 128
7. J. Kurzawa 1987 The iodine-azide reaction induced by mercaptopirimidines and its application in chemical analysis Chem. Anal. (Warsaw) 32 875 890
8. J. Kurzawa 1988 Oznaczanie mikro- i nanoilosci zwiazkow siarki (II) za pomoca ciaglej analizy przeplywowej z zastosowaniem indukowanej reakcji jodo-azydkowej Chem. Anal. (Warsaw) 33 771 777
9. J. Kurzawa A. Wioeniewska K. Janowicz 2006 Stopped-flow determination of 2-mercaptopyrimidines as inductors of the iodine-azide reaction Anal. Chim. Acta 567 286 292
10. P. Mitra A. T. Riga K. S. Alexander 2004 A rapid high-performance liquid chromatographic determination of propylthiouracil J. Liq. Chromatogr. Rel. Technol. 27 549 558
11. Y. Miura K. Fukasawa T. Koh 1998 Determination of sulfur anions at the ppb level by ion chromatography utilizing their catalytic effects on the post-column reaction of iodine with azide J. Chromatogr. A 804 143 150
12. Y. Miura M. Watanabe 2001 Ion-pair chromatography of polythionates and thiosulfate with detection based on their catalytic effect on the post-column azide-iodine reaction J. Chromatogr. A 920 163 171
13. R. Wilson J. H. McKillop M. Chopra J.A. Thomson 1988 The effect of antithyroid drugs on B and T cell activity in vitro Clin. Endocrinol. (Oxf). 28 389 397
14. G. Ying Ch. Min Y. Hua G. Xiao-hui Z. Ming-hui W. Haiyan 2007 The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil Int Immunopharmacol. 7 55 60
15. R. Zakrzewski W. Ciesielski 2003 Application of improved iodine-azide procedure for the detection of thiouracils in blood serum and urine with planar chromatography J. Chromatogr. B 784 283 290
16. R. Zakrzewski W. Ciesielski 2004 Application of iodine-azide reaction as post-column reaction in HPLC for determination of 2-thiobarbituric acid Chromatographia 59 683 689
17. R. Zakrzewski W. Ciesielski 2005 Determination of thiopental in urine sample with high-performance liquid chromatography using iodine-azide reaction as a post-column detection system J. Chromatogr. B 824 327 332