Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three african populations

PLoS ONE

Volumn 4, Issue 1, 2009, Pages

  Mangano, Valentina D ^a,b   Clark, Taane G ^a,c   Auburn, Sarah ^a,c   Campino, Susana ^a,c   Diakite, Mahamadou ^a   Fry, Andrew E ^a   Green, Angela ^a   Richardson, Anna ^a   Jallow, Muminatou ^d   Sisay Joof, Fatou ^d   Pinder, Margaret ^d   Griffiths, Michael J ^e   Newton, Charles ^e   Peshu, Norbert ^e   Williams, Thomas N ^e,f   Marsh, Kevin ^e,f   Molyneux, Malcolm E ^g,h   Taylor, Terrie E ^g,i   Modiano, David ^b   Kwiatkowski, Dominic P ^a,c   Rockett, Kirk A ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^e KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^g UNIVERSITY OF MALAWI   (Malawi)

^h LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

ⁱ MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 1;

AFRICA; ANEMIA; ARTICLE; BRAIN MALARIA; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FAMILY STUDY; GAMBIA; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOPATHOGENESIS; KENYA; MAJOR CLINICAL STUDY; MALARIA; MALAWI; PHENOTYPE; POPULATION RESEARCH; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; ADULT; FAMILY HEALTH; GENETICS; IMMUNOLOGY; PARENT;

PLASMODIUM FALCIPARUM;

ADULT; AFRICA; CHILD; FAMILY HEALTH; GAMBIA; HUMANS; INTERFERON REGULATORY FACTOR-1; KENYA; MALARIA; MALAWI; PARENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 58449114885     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004206     Document Type: Article

References (34)

1. Greenwood B, Mutabingwa T (2002) Malaria in 2002. Nature 415: 670-672.
2. Kwiatkowski DP (2005) How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 77: 171-192.
3. Lohoff M, Mak TW (2005) Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat Rev Immunol 5: 125-135.
4. Honda K, Taniguchi T (2006) Toll-like receptor signaling and IRF transcription factors. IUBMB Life 58: 290-295.
5. Ozato K, Tailor P, Kubota T (2007) The interferon regulatory factor family in host defense: mechanism of action. J Biol Chem 282: 20065-20069.
6. Mangano VD, Luoni G, Rockett KA, Sirima BS, Konate A, et al. (2008) Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection. Genes Immun 9: 122-129.
7. Ackerman H, Usen S, Jallow M, Sisay-Joof F, Pinder M, et al. (2005) A comparison of case-control and family-based association methods: the example of sickle-cell and malaria. Ann Hum Genet 69: 559-565.
8. Tishkoff SA, Williams SM (2002) Genetic analysis of African populations: human evolution and complex disease. Nat Rev Genet 3: 611-621.
9. Marchini J, Cardon LR, Phillips MS, Donnelly P (2004) The effects of human population structure on large genetic association studies. Nat Genet 36: 512-517.
10. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52: 506-516.
11. Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero JO, et al. (1997) Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349: 1650-1654.
12. Teo YY, Fry AE, Sanjoaquin MA, Pederson B, Small KS, et al. (2008) Assessing genuine parents-offspring trios for genetic association studies. Hum Heredity, 2008. In press.
13. Evans DM, Morris AP, Cardon LR, Sham PC (2006) A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test. Behav Genet 36: 947-50.
14. Clayton D (1999) A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65: 1170-1177.
15. Rabinowitz D, Laird N (2000) A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50: 211-223.
16. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
17. Plebanski M, Hill AV (2000) The immunology of malaria infection. Curr Opin Immunol 12: 437-441.
18. Luty AJ, Lell B, Schmidt-Ott R, Lehman LG, Luckner D, et al. (1999) Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children. J Infect Dis 179: 980-988.
19. Dodoo D, Omer FM, Todd J, Akanmori BD, Koram KA, et al. (2002) Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. J Infect Dis 185: 971-979.
20. Artavanis-Tsakonas K, Tongren JE, Riley EM (2003) The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology. Clin Exp Immunol 133: 145-152.
21. Mackinnon MJ, Mwangi TW, Snow RW, Marsh K, Williams TN (2005) Heritability of malaria in Africa. PLoS Med 2: e340.
22. Agarwal A, Guindo A, Cissoko Y, Taylor JG, Coulibaly D, et al. (2000) Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. Blood 96: 2358-2363.
23. Modiano D, Bancone G, Ciminelli BM, Pompei F, Blot I, et al. (2008) Haemoglobin S and haemoglobin C: 'quick but costly' versus 'slow but gratis' genetic adaptations to Plasmodium falciparum malaria. Hum Mol Genet 17: 789-799.
24. Sakuntabhai A, Ndiaye R, Casademont I, Peerapittayamonkol C, Rogier C, et al. (2008) Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal. PLoS ONE 3: e2000.
25. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, et al. (1995) Indicators of life-threatening malaria in African children. N Engl J Med 332: 1399-1404.
26. Mackintosh CL, Beeson JG, Marsh K (2004) Clinical features and pathogenesis of severe malaria. Trends Parasitol 20: 597-603.
27. Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, et al. (1992) Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A 89: 5847-5851.
28. Gonzalez JM, Portillo MC, Saiz-Jimenez C (2005) Multiple displacement amplification as a pre-polymerase chain reaction (pre-PCR) to process difficult to amplify samples and low copy number sequences from natural environments. Environ Microbiol 7: 1024-1028.
29. Ross P, Hall L, Smirnov I, Haff L (1998) High level multiplex genotyping by MALDI-TOF mass spectrometry. Nat Biotechnol 16: 1347-1351.
30. Teo YY, Fry AE, Clark TG, Tai ES, Seielstad M (2007) On the usage of HWE for identifying genotyping errors. Ann Hum Genet 71: 701-703; author reply 704.
31. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68: 978-989.
32. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
33. Wigginton JE, Abecasis GR (2005) PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 21: 3445-3447.
34. Clark T, Diakite M, Auburn S, Campino C, Fry AE, et al. (2008): Tumor necrosis factor and lymphotoxin alpha polymorphisms and severe malaria in African populations. J Infect Dis, 2008. In press.