Subacute toxicity of Crocus sativas L. (saffron) stigma ethanolic extract in rats

American Journal of Pharmacology and Toxicology

Volumn 2, Issue 4, 2007, Pages 189-193

  Mohajeri, Daryoush ^a   Mousavi, Ghafour ^a   Mesgari, Mehran ^b   Doustar, Yousef ^a   Nouri, Mir Hadi Khayat ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b UNIVERSITY OF TABRIZ   (Iran)

Author keywords

Crocus sativus L.; Ethanolic extract; Rat; Stigma; Subacute toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATINE; CROCUS SATIVUS EXTRACT; HEMOGLOBIN; UREA; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BLOOD TOXICITY; BODY WEIGHT; CONTROLLED STUDY; ERYTHROCYTE COUNT; HEMATOCRIT; HISTOPATHOLOGY; LD 50; LEUKOCYTE COUNT; LIVER TOXICITY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NEPHROTOXICITY; NONHUMAN; RAT; TOXICITY TESTING; WISTAR RAT;

ANIMALIA; CROCUS; CROCUS SATIVUS; RATTUS; RATTUS NORVEGICUS;

EID: 58449102386     PISSN: 15574962     EISSN: 15574970     Source Type: Journal    
DOI: 10.3844/ajptsp.2007.189.193     Document Type: Article

References (18)

1. Abe, K. and H. Saito, 2000. Effects of saffron and its constituent crocin on learning behavior and long-term potentiation. Phytother. Res., 14: 149-152. DOI: 10.1002/(SICI)1099-1573 (200005)14:3<149::AID-PTR665>3.0.CO;2-5.
2. Abdullaev, F.I., 2002. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp. Biol. Med., 227: 20-25. http://www.ebmonline.org/cgi/content/fult/2271/20.
3. Mohajeri, M., B. Amouoghli Tabrizi, Gh. Mousavi and M. Mesgari, 2008. Anti-diabetic activity of Crocus sativus L. (Saffron) stigma ethanolic extract in alloxan-induced diabetic rats. Res. J. Biol. Sci., 3: 1102-1108. http://medwelljournals.com/new/5/detail.php?id=5&jid= rjbs&theme=5&issuero=21&articleno=459.
4. Akhondzadeh, S., N. Tahmacebi-Pour, A.A. Noorbala, H. Amini, H. Fallah-Pour, A.H. Jamshidi and M. Khani, 2005. Crocus sativus in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial. Phytother. Res., 19: 148-151. Doi:10.1002/ ptr.1647.
5. Hosseinzadeh, H. and V. Khosravan, 2002. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus stigmas in mice. Arch. Irn. Med., 5: 44-47. http://www.ams.ac.ir/AIM/0251/aim025144.htm.
6. Salomi, M.J., S.C. Nair and P.R. Panikkar, 1991. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer, 16: 67-72. http://www.ncbi.nlm.nih.gov/pubmed/1923908.
7. Abdullaev, F.I., H. Caballero Ortega,, L. Riveron Negrette, R. Pereda Iranda, J.M. Hernandez and J. Perez Lopez, 2003. Use of in vitro assays to assess the potential genotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol. In vitro, 17: 731-736. Doi: 10.1016/S0887-2333(03)00098-5.
8. Abdullaev, F.I. and J.J. Espinosa-Aguirre, 2004. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Rev. Cancer Detec. Prev., 28: 426-432. Doi: 10.1016/ j.cdp.2004.09.002.
9. Martin, G., E. Goh and A.W. Neff, 2002. Evaluation of the developmental toxicity of crocetin on Xenopus. Food Chem. Toxicol., 40: 959-964. Doi: 10.1016/S0278-6915(02)00040-6.
10. Bisset, N.G. and M. Wichtl, 2001. Herbal Drugs and Phytopharmaceuticals. A Handbook for Practice on a Scientific Basis. 2nd Edn. Medpharin Scientific Publisher, CRC Press, London, pp: 167-169. http://www.amazon.ca/Herbal-Drugs-Phytopharmaceuticals-Handbook- Scientific/dp/0849310113.
11. Ghai, C.L., 2004. A Text Book of Practical Physiology. 6th Edn. Jaypee Brothers Medical Publishers, New Delhi, pp: 130-175. http://www.nbcindia.com/Descriptions.asp?6v6yr_vq=GHIMG&Buy+Book+ Online=A+Textbook+of+Practical+Physiology&by=Ghai.
12. Fawcett, J.K. and J.E. Scott, 1960. A rapid and precise method for the determination of urea. J. Clin. Pathol., 13: 156-159. Doi: 10.1136/jcp. 13.2.156.
13. Caraway, W.T., 1955. Determination of uric acid in serum by carbonate method. Am. J. Clin. Pathol., 25: 840-845. http://www.ncbi.nlm.nih.gov/ pubmed/14387986.
14. Burtis, C.A. and E.R. Ashwood, 1996. Teitz Fundamentals of Clinical Chemistry. 4th Edn. NB Saunders Company, Philadelphia, pp: 312-335. http://www.elsevier.com/wps/findibookdescription.cws_home/711187/ description#description.
15. Noorbala, A.A., S. Akhondzadeh, N. Tahmacebi-Pour and A.H. Jamshidi, 2005. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial. J. Ethnopharm., 97: 281-284. Doi:10.1016/j.jep.2004.11.004.
16. Moshiri, E., A. Akhondzadeh Basti, A.A. Noorbala, A.H. Jamshidi, S.H. Abbasi and S. Akhondzadeh, 2006. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomed., 13(9-10): 607-611. Doi:10.1016/ j.phymed.2006.08.006)
17. Whitehead, M.W., N.D. Hawkes, I. Hainsworth and G.C. Kingham, 1999. A prospective study of the causes of notably raised aspartate transaminase of liver origin. Gut, 45: 129-133. http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=1727583.
18. Cullen, J.M., 2007. Liver, Biliary system and Exocrine pancreas. In: Pathologic Basis of Veterinary Disease, 4th Edn., McGavin, M.D. and J.F. Zachary (Eds.). Mosby, London, pp: 403-406. http://www.elsevier.com/wps/ find/bookdescription.cws_home/708252/description#description.