Generation of goats lacking prion protein

Molecular Reproduction and Development

Volumn 76, Issue 1, 2009, Pages 3-

  Yu, Guohua ^a,b   Chen, Jianquan ^a   Xu, Yuanyuan ^c   Zhu, Caihong ^a   Yu, Huiqing ^a   Liu, Siguo ^a   Hongying, Sha ^a   Chen, Juan ^a   Xu, Xujun ^a   Wu, Youbing ^a   Zhang, Aimin ^a   Ma, Jiyan ^b   Cheng, Guoxiang ^a,c  

^a Shanghai Transgenic Research Center   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MESSENGER RNA; MONOCLONAL ANTIBODY; PRION PROTEIN;

BREEDING; DNA ISOLATION; FIBROBLAST; GENE; GENE LOCUS; GENOTYPE; GOAT; LETTER; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PRNP GENE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCRAPIE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; FEMALE; GENE KNOCKOUT TECHNIQUES; GOATS; MALE; PRIONS; SEQUENCE DELETION;

CAPRA HIRCUS;

EID: 58449100797     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20960     Document Type: Letter

References (3)

1. Büeler H, Fischer M, Lang Y, Bluethmann H, Lipp HP, DeArmond SJ, Prusiner SB, Aguet M, Weissmann C. 1992. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356:577-582.
2. Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, Sathiyaseelan J, Wu H, Matsushita H, Koster J, Kato S, Ishida I, Soto C, Robl JM, Kuroiwa Y. 2007. Production of cattle lacking prion protein. Nat Biotechnol 25:132-138.
3. Yu G, Chen J, Yu H, Liu S, Chen J, Xu X, Sha H, Zhang X, Wu G, Xu S, Cheng G. 2006. Function disruption of the prion protein gene in cloned goats. J Gen Virol 87:1019-1027.