The expanding role and presence of neuromelanins in the human brain - Why gray matter is gray

Pigment Cell and Melanoma Research

Volumn 22, Issue 1, 2009, Pages 10-11

  Hearing, Vincent J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EUMELANIN; NEUROMELANIN; PHEOMELANIN;

ALBINISM; BRAIN; BRAIN FUNCTION; DOPAMINERGIC NERVE CELL; GRAY MATTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LOCUS CERULEUS; MELANOGENESIS; NEUROPATHOLOGY; NEUROTOXICITY; PARKINSON DISEASE; PROTEIN BINDING; SCANNING ELECTRON MICROSCOPY; SHORT SURVEY; SUBSTANTIA NIGRA;

BRAIN; BRAIN DISEASES; HUMANS; MELANINS;

EID: 58449094271     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2008.00537.x     Document Type: Short Survey

References (6)

1. Eisenhofer, G., Tian, H., Holmes, C., Matsunaga, J., Roffler-Tarlov, S. Hearing, V.J. (2003). Tyrosinase: a developmentally-specific major determinant of peripheral dopamine. FASEB J., 17, 1248 1255.
2. Sulzer, D., Bogulavsky, J., Larsen, K.E. et al. (2000). Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc. Natl Acad. Sci. U.S.A., 97, 11869 11874.
3. Wakamatsu, K., Fujikawa, K., Zucca, F.A., Zecca, L. Ito, S. (2003). The structure of neuromelanin as studied by chemical degradative methods. J. Neurochem., 86, 1015 1023.
4. Zecca, L., Tampellini, D., Gatti, A., Crippa, R., Eisner, M., Sulzer, D., Ito, S., Fariello, R.G. Gallorini, M. (2002). The neuromelanin of human substantia nigra and its interaction with metals. J. Neural Transm., 109, 663 672.
5. Zecca, L., Bellei, C., Costi, P. et al. (2008). New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals. Proc. Natl. Acad. Sci. U.S.A., 105, 17567 17572.
6. Zucca, F.A., Giaveri, G., Gallorini, M. et al. (2004). The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment Cell Res., 17, 610 617.