Benefits and pitfalls of pooling datasets from comparable observational studies: Combining US and Dutch nursing home studies

Palliative Medicine

Volumn 22, Issue 6, 2008, Pages 750-759

  van der Steen, Jenny T ^a   Kruse, R L ^b   Szafara, K L ^c   Mehr, D R ^b   van der Wal, G ^a,d   Ribbe, M W ^a   D'Agostino, R B ^e  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b University of Missouri   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d Inspectorate of Health Care   (Netherlands)

^e BOSTON UNIVERSITY   (United States)

Author keywords

Data pooling; Epidemiologic research design; Meta analysis; Palliative care

Indexed keywords

ARTICLE; CLINICAL DECISION MAKING; FUNDING; HUMAN; INDIVIDUALITY; LOWER RESPIRATORY TRACT INFECTION; NETHERLANDS; NURSING HOME; NURSING METHODOLOGY RESEARCH; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; RESIDENTIAL CARE; TERMINAL CARE; TREATMENT OUTCOME; UNITED STATES; VALIDATION STUDY;

COST-BENEFIT ANALYSIS; HOMES FOR THE AGED; HUMANS; META-ANALYSIS AS TOPIC; MULTICENTER STUDIES AS TOPIC; NETHERLANDS; NORTH AMERICA; NURSING HOMES; PALLIATIVE CARE; RESEARCH DESIGN; RESPIRATORY TRACT INFECTIONS;

EID: 58449090014     PISSN: 02692163     EISSN: None     Source Type: Journal    
DOI: 10.1177/0269216308094102     Document Type: Article

References (48)

1. Vickers AJ. Whose data set is it anyway? Sharing raw data from randomized trials. Trials 2006; 7: 15.
2. Simmonds MC Higgins JP Stewart LA Tierney JF Clarke MJ Thompson SG. Meta-analysis of individual patient data from randomized trials: A review of methods used in practice. Clin Trials 2005; 2: 209-217.
3. Lambert PC Sutton AJ Abrams KR Jones DR. A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis. J Clin Epidemiol 2002; 55: 86-94.
4. Stewart L Tierney JF. To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Eval Health Prof 2002; 25: 76-97.
5. Stewart LA Clarke MJ. Practical methodology of meta-analyses (overviews) using updated individual patient data. Cochrane Working Group. Stat Med 1995; 14: 2057-2079.
6. Smith-Warner SA Spiegelman D Ritz J Albanes D Beeson WL Bernstein L. et al. Methods for pooling results of epidemiologic studies: The Pooling Project of Prospective Studies of Diet and Cancer. Am J Epidemiol 2006; 163: 1053-1064.
7. Blettner M Sauerbrei W Schlehofer B Scheuchenpflug T Friedenreich C. Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int J Epidemiol 1999; 28: 1-9.
8. Ioannidis JPA Lau J. Pooling research results: Benefits and limitations of meta-analysis. Jt Comm J Qual Improv 1999; 25: 462-469.
9. NHS Centre for Reviews and Dissemination. Undertaking systematic reviews of research on effectiveness: CRD report no 4. York: NHS Centre for Reviews and Dissemination, 2001.
10. Zeegers MPA Heisterkamp SH Kostense PJ van der Windt DAWM Scholten RJPM. The practice of systematic reviews. VII. Pooling the results of observational studies. Ned Tijdschr Geneeskd 2000; 144: 1393-1397 [In Dutch, English summary].
11. Justice AC Covinsky KE Berlin JA. Assessing the generalizability of prognostic information. Ann Intern Med 1999; 130: 515-524.
12. Charlson ME Ales KL Simon R MacKenzie CR. Why predictive indexes perform less well in validation studies. Is it magic or methods? Arch Intern Med 1987; 147: 2155-2161.
13. Morrison RS Siu AL. Survival in end-stage dementia following acute illness. JAMA 2000; 284: 47-52.
14. Fabiszewski KJ Volicer B Volicer L. Effect of antibiotic treatment on outcome of fevers in institutionalized Alzheimer patients. JAMA 1990; 263: 3168-3172.
15. van der Steen JT Ooms ME van der Wal G Ribbe MW. Withholding or starting antibiotic treatment in patients with dementia and pneumonia: Prediction of mortality with physicians' judgment of illness severity and with specific prognostic models. Med Decis Making 2005; 25: 210-221.
16. Mehr DR Binder EF Kruse RL Zweig SC Madsen R Popejoy L.,et al. Predicting mortality in nursing home residents with lower respiratory tract infection: The Missouri LRI Study. JAMA 2001; 286: 2427-2436.
17. van der Steen JT Ooms ME van der Wal G Ribbe MW. Pneumonia: The demented patient's best friend? Discomfort after starting or withholding antibiotic treatment. J Am Geriatr Soc 2002; 50: 1681-1688.
18. van der Steen JT Ooms ME Adèr HJ Ribbe MW van der Wal G. Withholding antibiotic treatment in demented patients with pneumonia. A quantitative observational study. Arch Intern Med 2002; 162: 1753-1760.
19. van der Steen JT Ooms ME Mehr DR van der Wal G. Ribbe, MW. Severe dementia and adverse outcomes of nursing home-acquired pneumonia: evidence for mediation by functional and patho-physiological decline. J Am Geriatr Soc 2002; 50: 439-448.
20. van der Steen JT. Curative or palliative treatment of pneumonia in psychogeriatric nursing home patients: Development and evaluation of a guideline, decision-making, and disease course. Amsterdam: VU University Medical Center; 2002. ISBN 90-5669-059-0 [Dissertation].
21. Mehr DR Binder EF Kruse RL Zweig SC Madsen R D'Agostino RB. Clinical findings associated with radiographic pneumonia in nursing home residents. J Fam Pract 2001; 50: 931-937.
22. Binder EF Kruse RL Sherman AK Madsen R Zweig SC D'Agostino R.,et al. Predictors of short-term functional decline in survivors of nursing home-acquired lower respiratory tract infection. J Gerontol A Biol Sci Med Sci 2003; 58: 60-67.
23. Kruse RL Mehr DR Boles KE Lave JR Binder EF Madsen R., et al. Does hospitalization impact survival after lower respiratory infection in nursing home residents? Med Care 2004; 42: 860-870.
24. Volicer L Hurley AC Lathi DC Kowall NW. Measurement of severity in advanced Alzheimer's disease. J Gerontol 1994; 49: M223-M226.
25. Morris JN Fries BE Mehr DR Hawes C Phillips C Mor V.,et al. MDS Cognitive Performance Scale. J Gerontol 1994; 49: M174-M182.
26. Helmes E Caapo KG Short JA. Standardization and validation of the Multidimensional Observation Scale for Elderly Subjects (MOSES). J Gerontol 1987; 42: 395-405.
27. van der Steen JT Volicer L Gerritsen DL Kruse RL Ribbe MW Mehr DR. Defining severe dementia with the Minimum Data Set. Int J Geriatr Psychiatry 2006; 21: 1099-1106.
28. Folstein MF Folstein SE McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
29. van der Steen JT Kruse RL Ooms ME Ribbe MW van der Wal G Heintz LL.,et al. Treatment of nursing home residents with dementia and lower respiratory tract infection in the United States and The Netherlands: An ocean apart. J Am Geriatr Soc 2004; 52: 691-699.
30. van der Steen JT Mehr DR Kruse RL Sherman AK Madsen RW D'Agostino RB, et al. Predictors of mortality for lower respiratory infections in nursing home residents with dementia were validated transnationally. J Clin Epidemiol 2006; 59: 970-979.
31. van der Steen JT Mehr DR Kruse RL Ribbe MW van der Wal G. Treatment strategy and risk of functional decline and mortality after nursing-home acquired lower respiratory tract infection: Two prospective studies in residents with dementia. Int J Geriatr Psychiatry 2007; 22: 1013-1019.
32. van der Steen JT Mehr DR Kruse RL Ribbe MW van der Wal G. Dementia, lower respiratory tract infection and long-term mortality. J Am Med Dir Assoc 2007; 8: 396-403.
33. van der Steen JT Kruse RL van der Wal G Mehr DR Ribbe MW. Treatment of pneumonia in nursing home residents with severe dementia: For residents with poor prognosis, a more reserved approach in The Netherlands and more active treatment in the United States. Ned Tijdschr Geneeskd 2007; 151: 915-919 [Dutch].
34. Kruse RL Mehr DR van der Steen JT Ooms ME Madsen RW Sherman AK, et al. Antibiotic treatment and survival of nursing home patients with lower respiratory tract infection: A cross-national analysis. Ann Fam Med 2005; 3: 422-429.
35. Mehr DR van der Steen JT Kruse RL Ooms ME Rantz M Ribbe MW. Lower respiratory infections in nursing home residents with dementia: A tale of two countries. Gerontologist 2003; 43 (Suppl. 2): 85-93.
36. van der Steen JT van der Wal G Mehr DR Ooms ME Ribbe MW. End-of-life decision making in nursing home residents with dementia and pneumonia: Dutch physicians' intentions regarding hastening death. Alzheimer Dis Assoc Disord 2005; 19: 148-155.
37. van der Steen J Kruse R Mehr D Ribbe M Ooms M Frijters D, et al. Decline after a lower respiratory tract infection in US and Dutch nursing home residents with dementia. Gerontologist 2005; 45(Spec No 2): 446 [abstract].
38. van der Steen JT Kruse RL Mehr DR Ribbe MW van der Wal G. Dementia severity, decline and improvement after a lower respiratory tract infection. J Nutr Health Aging 2007; 11: 502-506.
39. Szafara KL Mehr DR Kruse RL van der Steen JT Ooms ME Ribbe MW, et al. Non-antibiotic treated nursing home-acquired lower respiratory infection: An international comparison of treatments and outcomes. Gerontologist 2003; 43(Spec No 1): 491 [abstract].
40. Higginson IJ. End-of-life care: Lessons from other nations. J Palliat Med 2005; 8(Suppl. 1): S161-S173.
41. Christakis NA. Advances in palliative care research methodology. Palliat Med 2006; 20: 725-726.
42. Kaasa S Hjermstad MJ Loge JH. Methodological and structural challenges in palliative care research: How have we fared in the last decades. Palliat Med 2006; 20: 727-734.
43. Fery-Lemonnier E Landais P Loirat P Kleinknecht D Brivet F. Evaluation of severity scoring systems in ICUs-translation, conversion and definition ambiguities as a source of inter-observer variability in Apache II, SAPS and OSF. Intensive Care Med 1995; 21: 356-360.
44. Rothwell PM Eliasziw M Gutnikov SA Fox AJ Taylor DW Mayberg MR, et al. Carotid Endarterectomy Trialists' Collaboration. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 2003; 361: 107-116.
45. Mulrow C Langhorne P Grimshaw J. Integrating heterogeneous pieces of evidence in systematic reviews. Ann Intern Med 1997; 127: 989-995.
46. Stukel TA Fisher ES Wennberg DE. Analytic approaches to observational studies with treatment selection bias. JAMA 2007; 297:2077- 2078 [author reply 2078].
47. Murphy-Filkins R Teres D Lemeshow S Hosmer DW. Effect of changing patient mix on the performance of an intensive care unit severity-of-illness model: How to distinguish a general from a specialty intensive care unit. Crit Care Med 1996; 24: 1968-1973.
48. Glance LG Osler TM Papadakos P. Effect of mortality rate on the performance of the Acute Physiology and Chronic Health Evaluation II: A simulation study. Crit Care Med 2000; 28: 3424-3428.