Role of muscarinic signal transduction and CREB phosphorylation in dichlorvos-induced memory deficits in rats: An acetylcholine independent mechanism

Toxicology

Volumn 256, Issue 3, 2009, Pages 175-182

  Verma, Suresh Kumar ^a   Raheja, Geetu ^a   Gill, Kiran Dip ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Cholinesterases; CREB; Morris water maze; Muscarinic receptors; Neurobehavior; Organophosphate

Indexed keywords

ACETYLCHOLINESTERASE; ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DICHLORVOS; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; PHOSPHOLIPASE C;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IN VIVO STUDY; MALE; MAZE TEST; MEMORY; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; CHOLINESTERASE INHIBITORS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DICHLORVOS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; MEMORY DISORDERS; MOTOR ACTIVITY; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SYNAPTIC MEMBRANES;

ANIMALIA; RATTUS;

EID: 58349118718     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.11.017     Document Type: Article

References (43)

1. Balali-Mood M., and Balali-Mood K. Neurotoxic disorders of organophosphorus compounds and their managements. Arch. Iran. Med. 11 (2008) 65-89
2. Bergers M., Lendi S., and Mier P.D. Phosphatidylinositol 4,5-bisphosphate phospholipase C activity in particulate preparations from rat brain. Lipids 24 (1989) 13-16
3. Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., and Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79 (1994) 59-68
4. Canadas F., Cardona D., Davila E., and Sanchez-Santed F. Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. Toxicol. Sci. 85 (2005) 944-951
5. Caughlan A., Newhouse K., Namgung U., and Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicol. Sci. 78 (2004) 125-134
6. Cheung W.Y., Bradham L.S., Lynch T.J., Lin Y.M., and Tallant E.A. Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase. Biochem. Biophys. Res. Commun. 66 (1975) 1055-1062
7. Costa L.G., Schwab B.W., and Murphy S.D. Differential alterations of cholinergic muscarinic receptors during chronic and acute tolerance to organophosphorus insecticides. Biochem. Pharmacol. 31 (1982) 3407-3413
8. Cummings J.L., Mackell J., and Kaufer D. Behavioral effects of current Alzheimer's disease treatments: a descriptive review. Alzheimers Dement. 4 (2008) 49-60
9. Damodaran T.V., Patel A.G., Greenfield S.T., Dressman H.K., Lin S.M., and Abou-Donia M.B. Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. Biochem. Pharmacol. 71 (2006) 497-520
10. Deer H.M., Beck E.D., and Roe A.H. Respiratory exposure of museum personnel to dichlorvos insecticide. Vet. Hum. Toxicol. 35 (1993) 226-228
11. Dunham N.W., and Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharm. Assoc. Am. Pharm. Assoc. Baltim. 46 (1957) 208-209
12. Eckel-Mahan K.L., Phan T., Han S., Wang H., Chan G.C., Scheiner Z.S., and Storm D.R. Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence. Nat. Neurosci. (2008) 10.1038/nn.2174
13. Eddleston M., Karalliedde L., Buckley N., Fernando R., Hutchinson G., Isbister G., Konradsen F., Murray D., Piola J.C., Senanayake N., Sheriff R., Singh S., Siwach S.B., and Smit L. Pesticide poisoning in the developing world-a minimum pesticides list. Lancet 360 (2002) 1163-1167
14. Eldefrawi A.T., Jett D., and Eldefrawi M.E. Direct actions of organophosphate anticholinesterases on muscarinic receptors. In: Chambers J.E., and Levi P.E. (Eds). Organophosphates: Chemistry, Fate and Effects (1992), Academic Press, New York 257-270
15. Ellman G.L., Courtney K.D., Andres Jr. V., and Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
16. Eskenazi B., Bradman A., and Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ. Health Perspect. 107 Suppl. 3 (1999) 409-419
17. Farahat T.M., Abdelrasoul G.M., Amr M.M., Shebl M.M., Farahat F.M., and Anger W.K. Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. Occup. Environ. Med. 60 (2003) 279-286
18. Fiedler N., Kipen H., Kelly-McNeil K., and Fenske R. Long-term use of organophosphates and neuropsychological performance. Am. J. Ind. Med. 32 (1997) 487-496
19. Frey U., Huang Y.Y., and Kandel E.R. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260 (1993) 1661-1664
20. Guo-Ross S.X., Chambers J.E., Meek E.C., and Carr R.L. Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion. Toxicol. Sci. 100 (2007) 118-127
21. Jett D.A. Neurological aspects of chemical terrorism. Ann. Neurol. 61 (2007) 9-13
22. Jett D.A., Navoa R.V., Beckles R.A., and McLemore G.L. Cognitive function and cholinergic neurochemistry in weanling rats exposed to chlorpyrifos. Toxicol. Appl. Pharmacol. 174 (2001) 89-98
23. Jones D.H., and Matus A.I. Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation. Biochim. Biophys. Acta. 356 (1974) 276-287
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
25. Lonze B.E., and Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35 (2002) 605-623
26. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
27. Milby T.H. Prevention and management of organophosphate poisoning. JAMA 216 (1971) 2131-2133
28. Moretto A., Lotti M., Sabri M.I., and Spencer P.S. Progressive deficit of retrograde axonal transport is associated with the pathogenesis of di-n-butyl dichlorvos axonopathy. J. Neurochem. 49 (1987) 1515-1522
29. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11 (1984) 47-60
30. Nogues X. Protein kinase C, learning and memory: a circular determinism between physiology and behaviour. Prog. Neuropsychopharmacol. Biol. Psychiatry 21 (1997) 507-529
31. Piala J.J., High J.P., Hassert Jr. G.L., Burke J.C., and Craver B.N. Pharmacological and acute toxicological comparisons of triflupromazine and chlorpromazine. J. Pharmacol. Exp. Ther. 127 (1959) 55-65
32. Prendergast M.A., Terry Jr. A.V., and Buccafusco J.J. Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning. Psychopharmacology (Berl.) 129 (1997) 183-191
33. Rohlman D.S., Lasarev M., Anger W.K., Scherer J., Stupfel J., and McCauley L. Neurobehavioral performance of adult and adolescent agricultural workers. Neurotoxicology 28 (2007) 374-380
34. Salomon Y., Londos C., and Rodbell M. A highly sensitive adenylate cyclase assay. Anal. Biochem. 58 (1974) 541-548
35. Sarin S., and Gill K.D. Dichlorvos induced alterations in glucose homeostasis: possible implications on the state of neuronal function in rats. Mol. Cell. Biochem. 199 (1999) 87-92
36. Sato N., Kamino K., Tateishi K., Satoh T., Nishiwaki Y., Yoshiiwa A., Miki T., and Ogihara T. Elevated amyloid beta protein 1-40 level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase Erk1/2-dependent pathway in rat pheochromocytoma PC12 cells. Biochem. Biophys. Res. Commun. 232 (1997) 637-642
37. Shaywitz A.J., and Greenberg M.E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68 (1999) 821-861
38. Sloboda R.D., Rudolph S.A., Rosenbaum J.L., and Greengard P. Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein. Proc. Natl. Acad. Sci. USA 72 (1975) 177-181
39. Suwita E., Lapadula D.M., and Abou-Donia M.B. Calcium and calmodulin stimulated in vitro phosphorylation of rooster brain tubulin and MAP-2 following a single oral dose of tri-o-cresyl phosphate. Brain Res. 374 (1986) 199-203
40. Volpicelli L.A., and Levey A.I. Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus. Prog. Brain Res. 145 (2004) 59-66
41. Wang H., Han H., Zhang L., Shi H., Schram G., Nattel S., and Wang Z. Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart. Mol. Pharmacol. 59 (2001) 1029-1036
42. 4 receptors in rat frontal cortex. Brain Res. Bull. 39 (1996) 49-55
43. Yamada S., Isogai M., Okudaira H., and Hayashi E. Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration: antagonism by physostigmine and atropine. J. Pharmacol. Exp. Ther. 226 (1983) 519-525