Enteroaggregative Escherichia coli infection

Current Opinion in Gastroenterology

Volumn 25, Issue 1, 2009, Pages 8-11

  Flores, Jose ^a   Okhuysen, Pablo C ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b NONE   (United States)

Author keywords

Diarrhea; Enteroaggregative Escherichia coli; Gastrointestinal infections; Travelers' diarrhea

Indexed keywords

AZITHROMYCIN; CELL PROTEIN; COLLAGEN TYPE 4; FIBRONECTIN; LACTOFERRIN; LAMININ; LOPERAMIDE; PILIN; RIFAXIMIN; SCLEROPROTEIN; VIRULENCE FACTOR;

BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; CELL STRAIN HEPG2; CHEMOPROPHYLAXIS; CHRONIC DIARRHEA; CHRONIC DISEASE; CLINICAL ASSESSMENT; CLINICAL FEATURE; DEVELOPED COUNTRY; DEVELOPING COUNTRY; ENTEROAGGREGATIVE ESCHERICHIA COLI; FOOD CONTAMINATION; HUMAN; IMMUNOGENICITY; IRRITABLE COLON; MALNUTRITION; NONHUMAN; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN AGGREGATION; REVIEW; TRAVELLER DIARRHEA; UNITED STATES;

DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM; DISEASE OUTBREAKS; DNA, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; INTESTINAL DISEASES; VIRULENCE; WORLD HEALTH;

EID: 58349111337     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32831dac5e     Document Type: Review

References (22)

1. Araujo JM, Tabarelli GF, Aranda KR, et al. Typical enteroaggregative and • atypical enteropathogenic types of Escherichia coli are the most prevalent diarrhea-associated pathotypes among Brazilian children. J Clin Microbiol 2007; 45:3396-3399. This prospective study done in Sao Paulo, Brazil, in small children included more than 700 patients with diarrhea and found EAEC in 11 % of diarrheal episodes. Surprisingly, the rates of EAEC were significantly higher in patients belonging to the higher socioeconomic status strata.
2. Huang DB, Brown EL, DuPont HL, et al. Seroprevalence of the enteroag- • gregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study. J Med Microbiol 2008; 57:476-479. This study includes 195 US students traveling to Mexico with a mean stay of 19 days. Forty-nine percent of travelers seroconverted to EAEC dispersin, as determined by an IgG ELISA test. Asymptomatic seroconversion was common.
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11. Velarde JJ, Varney KM, Inman KG, et al. Solution structure of the novel •• dispersin protein of enteroaggregative Escherichia coli. Mol Microbiol 2007;66:1123-1135. This study solved the structure of dispersin from EAEC strain 042 using solution nuclear magnetic resonance spectroscopy and proposes a potential mechanism of action for dispersin.
12. Imuta N, Nishi J, Tokuda K, et al. The Escherichia coli efflux pump TolC • promotes aggregation of enteroaggregative E. coli 042. Infect Immun 2008; 76:1247-1256. In this Japanese study, the authors mutated the To1C gene in the prototype EAEC 042 strain and showed that TolC does not export dispersin but that it does promote bacterial aggregation. This suggests the presence of a yet to be described factor that is exported by TolC and contributes to the aggregative phenotype.
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